Patents Assigned to SANDOZ
  • Regioselective acylation of rapamycin at the C-42 position
    Patent number: 9051336
    Abstract: The invention refers to the selective acylation of Rapamycin at the 42-position (I) with an acylating agent of the formula (II) wherein R4 and R5 are the same or different, individually the rest of an acetal, especially tetrahydropyran, or of a carbonate or the rest of a silyl ether or taken together are the rest of a boronate, an acetal or ketal.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: June 9, 2015
    Assignee: SANDOZ
    Inventors: Wolfgang Felzmann, Niklas Schone