Patents Assigned to Sandoz GmbH
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Patent number: 10106828Abstract: The present invention is related to a cell culture medium for the expression of a protein, which medium comprises a PAM inhibitor, or a physiological equivalent thereof, and to a cell culture process for the expression of a protein, in which process a PAM inhibitor, or a physiological equivalent thereof, is used (FIG. 1).Type: GrantFiled: May 26, 2015Date of Patent: October 23, 2018Assignee: SANDOZ GMBHInventors: Corinna Sonderegger, Julia Schmutzhard, Christine Heel, Thomas Stangler
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Patent number: 9062337Abstract: The present invention is related to a cell culture medium for the expression of a protein, which medium comprises a PAM inhibitor, or a physiological equivalent thereof, and to a cell culture process for the expression of a protein, in which process a PAM inhibitor, or a physiological equivalent thereof, is used (FIG. 1).Type: GrantFiled: November 9, 2011Date of Patent: June 23, 2015Assignee: Sandoz GmbHInventors: Corinna Sonderegger, Julia Schmutzhard, Christine Heel, Thomas Stangler
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Patent number: 8691534Abstract: The invention provides an improved process for preparing romidepsin. The process involves producing, purifying, or storing romidepsin under conditions that prevent the formation of undesired adducts. Purifying romidepsin at an apparent pH lower than approximately 6.0 (e.g., between an apparent pH of 4.0 and 6.0) has been discovered to prevent the reduction of the disulfide bond of romidepsin and the subsequent formation of dimerized, oligomerized, or polymerized adducts. The invention also provides compositions of monomeric romidepsin free of dimerized, oligomerized, or polymerized adducts.Type: GrantFiled: December 28, 2007Date of Patent: April 8, 2014Assignees: Celgene Corporation, Sandoz GmbHInventors: Gregory L. Verdine, Nicholas H. Vrolijk, Stephan Bertel
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Patent number: 8652517Abstract: A process for the coating of tablet cores, said tablet core comprising an effective amount of at least one pharmaceutically active compound, comprising spraying a coating solution or suspension comprising a sugar, or a starch, or a mixture of a sugar and a starch onto the tablets or tablet cores with the proviso that film-forming agents in the coating solution or suspension are excluded, to obtain coated tablets, such coated tablets and corresponding coating mixtures.Type: GrantFiled: September 22, 2005Date of Patent: February 18, 2014Assignee: Sandoz GmbHInventors: Reinhard Entner, Herwig Jennewein
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Publication number: 20130337506Abstract: The present invention is related to a cell culture medium for the expression of a protein, which medium comprises a PAM inhibitor, or a physiological equivalent thereof, and to a cell culture process for the expression of a protein, in which process a PAM inhibitor, or a physiological equivalent thereof, is used (FIG. 1).Type: ApplicationFiled: November 9, 2011Publication date: December 19, 2013Applicant: SANDOZ GMBHInventors: Corinna Sonderegger, Julia Schmutzhard, Christine Heel, Thomas Stangler
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Patent number: 7807196Abstract: Process for drying amoxicillin (compositions), characterised in that a gas, which is inert towards amoxicillin (compositions) and having a relative humidity content which is greater than zero is used for drying.Type: GrantFiled: May 28, 2001Date of Patent: October 5, 2010Assignee: Sandoz GmbHInventors: Hans W Bilke, Otto Daemon, Franz X Schwarz
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Patent number: 7355041Abstract: A salt of PACA with an amidine and its use in the production of cefprozil.Type: GrantFiled: July 31, 2002Date of Patent: April 8, 2008Assignee: Sandoz GmbHInventors: Julia Greil, Johannes Ludescher, Siegfried Wolf
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Patent number: 7317101Abstract: A compound of formula wherein Ac, R1 and R2 have various meanings, a process for a preparation thereof and its use as a pharmaceutical, i.e. as antibacterial agent.Type: GrantFiled: December 3, 2002Date of Patent: January 8, 2008Assignee: Sandoz GmbHInventors: Gerd Ascher, Johannes Ludescher
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Publication number: 20070207519Abstract: A CPC acylase mutant of the present invention has an improved reactivity and specific activity to CPC, which can be efficiently employed for directly preparing 7-ACA from CPC by a one-step enzymatic method.Type: ApplicationFiled: August 10, 2004Publication date: September 6, 2007Applicant: SANDOZ GMBHInventors: Yong Shin, John Jeon, Kyung Jung, Mi Park, Youngso Kim
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Patent number: 6894162Abstract: Cefuroxime in the form of a salt with n-butylamine; and its use for the production of cefuroxime axetil or for the production of the sodium salt of cefuroxime.Type: GrantFiled: September 10, 2001Date of Patent: May 17, 2005Assignee: Sandoz GmbHInventor: Peter Kremminger
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Patent number: 6835829Abstract: Processes for the depletion of 7-ADCA in mixtures of vinyl-ACA with 7-ADCA via novel salts of vinyl-ACA or via chromatography.Type: GrantFiled: January 21, 2003Date of Patent: December 28, 2004Assignee: Sandoz GmbHInventors: Johannes Ludescher, Werner Veit
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Patent number: 6825345Abstract: A process for the purification of cefixime via a novel tert-octylamine salt of a cefixime intermediate of formula V which may be crystalline and which may be produced in a one-pot reaction from 7-amino-3-vinyl-ceph-3-em-4-carboxylic acid.Type: GrantFiled: September 30, 2002Date of Patent: November 30, 2004Assignee: Sandoz GmbHInventors: Martin Decristoforo, Johannes Ludescher, Hubert Sturm, Werner Veit
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Patent number: 6787649Abstract: A process which comprises (i) acylating a compound of formula II with a compound of formula IV to obtain a compound of formula I and (ii) deformylating said compound of formula I to obtain a compound of formula IIIType: GrantFiled: February 12, 2003Date of Patent: September 7, 2004Assignee: Sandoz GmbHInventors: Peter Kremminger, Johannes Ludescher, Siegfried Wolf
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Patent number: 6784193Abstract: A compound of formula (I) wherein R2 is arylene or heterocyclene; or R and R2 together with the nitrogen atom to which they are attached form non-aromatic heterocyclene; and the other residues have various meanings, useful as pharmaceuticals, e.g. antimicrobials.Type: GrantFiled: January 28, 2002Date of Patent: August 31, 2004Assignee: Sandoz GmbHInventors: Gerd Ascher, Heinz Berner, Johannes Hildebrandt
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Patent number: 6777549Abstract: A process for the production of a compound of formula comprising i) silylating a compound of formula then reacting a resulting with a compound of formula R′BS—X′ IVB wherein R′B is hydrogen or trialkysilyl and X′ is as defined above, in the presence of a compound of formula wherein R2, R3 and R4 independently of each another are aryl or alkyl, and R5 is alkyl, perfluorinated alkyl, or aryl; and isolating the desired product.Type: GrantFiled: April 10, 2002Date of Patent: August 17, 2004Assignee: Sandoz GmbHInventors: Benjamin Gerlach, Johannes Ludescher, Klaus Totschnig