Patents Assigned to Sandoz Inc.
  • Cyclopropanyl-bearing hydrazides
    Patent number: 4201785
    Abstract: Cyclopropanyl-group-bearing-hydrazides, e.g. cis-2-octyl-cyclopropanoctanoic acid, 2-(o-methylphenyl)-hydrazide, are useful as pharmaceutical agents and are obtainable by reacting a derivative, e.g. mixed anhydride, of a cyclopropanyl-group bearing-long chain carboxylic acid with an appropriate hydrazine.
    Type: Grant
    Filed: April 4, 1979
    Date of Patent: May 6, 1980
    Assignee: Sandoz Inc.
    Inventor: Faizulla G. Kathawala
  • 1-Substituted-2-disubstitutedamino-pyrido[2,3-D]pyrimidin-4(1H)-ones
    Patent number: 3931183
    Abstract: Anti-histaminics of the formula ##SPC1##Wherein R.sub.1 is alkyl, alkenyl or phenalkyl, R.sub.2 and R.sub.3 are alkyl or alkenyl and R' is optional are prepared by alkylating or alkenylating a 1-substituted-2-monosubstituted-amino pyrido 2,3-d pyrimidin-4(1H)-one with an alkyl halide or alkenyl halide.
    Type: Grant
    Filed: July 24, 1974
    Date of Patent: January 6, 1976
    Assignee: Sandoz Inc.
    Inventor: Goetz E. Hardtmann
  • Hydroxyalkyl substituted-4,5-dihydropyridazin(2H)-3-ones
    Patent number: 3931176
    Abstract: Hydroxyalkyl and aryl or heterocyclic substituted-4,5-dihydropyridazin(2H)-3-ones and diazabicyclo-ene-ones e.g., 6-(p-chloro-phenyl)-2-(2-hydroxybutyl)-4,5-dihydropyridazin(2H)-3-on e are prepared by condensing 1-hydrazino-2-alkanols with aryl or heterocyclic-.gamma.-keto acids and are useful as central nervous system depressants.
    Type: Grant
    Filed: October 25, 1973
    Date of Patent: January 6, 1976
    Assignee: Sandoz Inc.
    Inventor: William J. Houlihan
  • Bis(4-(4-hydroxybenzyl)phenyl) carbonic acid ester
    Patent number: 3931275
    Abstract: Bis (4-[4-hyroxybenzyl]phenyl)carbonic acid ester and its pharmaceutically acceptable salts, are useful in the treatment of lipidemia.
    Type: Grant
    Filed: December 3, 1973
    Date of Patent: January 6, 1976
    Assignee: Sandoz Inc.
    Inventor: Mario Gustav Buzzolini
  • 1-Tertiary-butyl-3-morpholino-3-phenyl-2,1-benzisoxaxolines
    Patent number: 3931172
    Abstract: The invention discloses 1-tertiary-butyl-3-morpholino-3-phenyl-2,1-benzisoxazolines having pharmacological activity in animals and useful, for example, as hypolipidemic agents. The compounds may be prepared by reacting a 1-tertiary-butyl-3-phenyl-2,1-benzisoxazolium quaternary salt, e.g., 1-tertiary-butyl-3-phenyl-2,1-benzisoxazolium tetrafluoroborate with morpholine. The 1-tertiary-butyl-3-phenyl-2,1-benzisoxazolium quaternary salt may be prepared by reaction of a corresponding 3-phenyl-2,1-benzisoxazole with tertiary-butanol in the presence of a strong inorganic acid.
    Type: Grant
    Filed: February 25, 1974
    Date of Patent: January 6, 1976
    Assignee: Sandoz Inc.
    Inventors: Robert V. Coombs, Goetz E. Hardtmann
  • N,N-Bis(4-Quinazolinyl)alkanediamines
    Patent number: 3931179
    Abstract: Disclosed are N,N'-Bis(4-Quinazolinyl)alkanediamines, e.g., N,N'-Bis(7-chloro-4-quinazolinyl)-1,9-nonanediamine, having pharmacological activity in animals and useful for example, as anti-obesity agents. Said compounds may be prepared by reacting a 4-haloquinazoline with an alkanediamine.
    Type: Grant
    Filed: March 6, 1974
    Date of Patent: January 6, 1976
    Assignee: Sandoz Inc.
    Inventor: William R. J. Simpson
  • 1-Substituted-2-imino-pyrido[2,3-d]pyrimidin-4(1H)-ones
    Patent number: 3931178
    Abstract: ANTI-HISTAMINICS OF THE FORMULA: ##SPC1##whereinR.sub.1 is alkyl, alkenyl or phenalkyl,R.sub.2 and R.sub.3 are hydrogen, alkyl or alkenyl, andR is an optional substituent, are prepared by reacting a 3,4-dihydro-1,3-dioxo-1H-pyrido [2,3-d][1,3]oxazine (a 3-azaisatoic anhydride) with a S-methyl-thiopseudourea.
    Type: Grant
    Filed: July 24, 1974
    Date of Patent: January 6, 1976
    Assignee: Sandoz Inc.
    Inventor: Goetz E. Hardtmann