Patents Assigned to Sanford-Burnham Medical Research Institute
  • Patent number: 11382880
    Abstract: Disclosed herein are methods for improving digestive health by providing a consumable composition. Some embodiments provided include, for example, administering a compound of Formula (I) or compound of Formula (II). Some embodiments provide the composition is formulated as a dietary supplement, food ingredient or additive, a medical food, nutraceutical or pharmaceutical composition.
    Type: Grant
    Filed: January 4, 2021
    Date of Patent: July 12, 2022
    Assignees: Brightseed, Inc., Sanford-Burnham Medical Research Institute
    Inventors: Lee Heil Chae, Fred Levine
  • Patent number: 11260133
    Abstract: Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: March 1, 2022
    Assignee: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventors: Erkki Ruoslahti, Tambet Teesalu, Kazuki Sugahara
  • Patent number: 11059718
    Abstract: Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.
    Type: Grant
    Filed: July 29, 2019
    Date of Patent: July 13, 2021
    Assignee: Sanford-Burnham Medical Research Institute
    Inventors: Erkki Ruoslahti, Tambet Teesalu, Kazuki Sugahara
  • Patent number: 10787439
    Abstract: N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: September 29, 2020
    Assignees: UNIVERSITY OF KANSAS, THE REGENTS OF THE UNIVERSITY OF MICHIGAN, SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE, WAYNE STATE UNIVERSITY
    Inventors: Jennifer E. Golden, Jeffrey Aube, Daniel P. Flaherty, Andrew M. Fribley, Randal J. Kaufman, Thomas D. Y. Chung, Anthony B. Pinkerton, Michael Pablo Hedrick
  • Patent number: 10611733
    Abstract: Provided is a method for treating or preventing a viral infection in a subject, wherein the viral infection is from a flavivirus selected from the group consisting of Hepatitis C Virus (genotypes 1-7) and Japanese Encephalitis Virus, as well as novel compounds that are useful in the method.
    Type: Grant
    Filed: February 6, 2017
    Date of Patent: April 7, 2020
    Assignees: Sanford-Burnham Medical Research Institute, Southern Research Institute
    Inventors: Marintha L. Heil, Nicholas D. P. Cosford, Robert Ardecky, Jiwen Zou
  • Patent number: 10370245
    Abstract: Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: August 6, 2019
    Assignee: Sanford-Burnham Medical Research Institute
    Inventors: Erkki Ruoslahti, Tambet Teesalu, Kazuki Sugahara
  • Patent number: 10259844
    Abstract: Provided herein are compositions and methods for selectively targeting an endometriosis cell.
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: April 16, 2019
    Assignee: Sanford-Burnham Medical Research Institute
    Inventors: Michiko Fukuda, Daisuke Aoki, Shiro Nozawa
  • Patent number: 10227561
    Abstract: The invention provides methods, compositions and kits for the identification and enrichment of progenitor cell lines obtained from pluripotent stem cells.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: March 12, 2019
    Assignees: Mandala Biosciences, LLC, BioTime, Inc., Sanford-Burnham Medical Research Institute
    Inventors: Dana Larocca, Paola Bignone, Michael D. West, Evan Snyder
  • Patent number: 10179801
    Abstract: Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences, such as truncated LyP-1 peptides, that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: January 15, 2019
    Assignee: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventors: Erkki Ruoslahti, Tambet Teesalu, Kazuki Sugahara, Lise Roth
  • Publication number: 20180307005
    Abstract: Multifunction autofocus for automated microscopy includes automatic coarse focusing of an automated microscope by reflective positioning, followed by automatic image-based autofocusing of the automated microscope performed in reference to a coarse focus position. In some aspects, the image-based autofocusing utilizes astigmatism in microscope optics for multi-planar image acquisition along a Z axis direction of a microscope. In some other aspects, the image-based autofocusing utilizes astigmatism in microscope optics in combination with chromatic aberration for multi-planar image acquisition along the Z axis direction.
    Type: Application
    Filed: June 18, 2018
    Publication date: October 25, 2018
    Applicants: Sanford-Burnham Medical Research Institute, Vala Sciences, Inc.
    Inventors: Jeffrey H. Price, Derek N. Fuller, Albert L. Kellner, Behrad Azimi
  • Patent number: 10099993
    Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor positive allosteric modulators (PAMS), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: October 16, 2018
    Assignee: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventors: Raveendra Panickar Dhanya, Douglas J. Sheffler, Nicholas D. P. Cosford, Russell Dahl
  • Patent number: 10047119
    Abstract: Provided herein are compounds that modulate the activity of inhibitor of apoptosis proteins (IAPB), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: August 14, 2018
    Assignee: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventors: Nicholas David Peter Cosford, Mitchell Dennis Vamos
  • Patent number: 10039838
    Abstract: Disclosed are compositions and methods useful for delivering targeted therapies for pulmonary diseases, fibrotic disorders and cancer. The compositions and methods are based on peptide sequences that selectively bind to and home to diseased tissue and enable targeted therapies to effect a beneficial therapeutic result. The disclosed targeting is useful for delivering therapeutic and detectable agents to diseased tissue in an animal.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: August 7, 2018
    Assignees: Vascular Biosciences, Sanford-Burnham Medical Research Institute
    Inventors: Masanobu Komatsu, David Mann, Erkki Ruoslahti
  • Patent number: 10001622
    Abstract: Multifunction autofocus for automated microscopy includes automatic coarse focusing of an automated microscope by reflective positioning, followed by automatic image-based autofocusing of the automated microscope performed in reference to a coarse focus position. In some aspects, the image-based autofocusing utilizes astigmatism in microscope optics for multi-planar image acquisition along a Z axis direction of a microscope. In some other aspects, the image-based autofocusing utilizes astigmatism in microscope optics in combination with chromatic aberration for multi-planar image acquisition along the Z axis direction.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: June 19, 2018
    Assignees: Sanford Burnham Medical Research Institute, Vala Sciences, Inc.
    Inventors: Jeffrey H. Price, Derek N. Fuller, Albert L. Kellner, Behrad Azimi
  • Patent number: 10001470
    Abstract: The present invention provides a method, system and composition for screening drug candidates for cardiotoxicity and for novel drugs that effect cardiomyocyte contractility and function. The invention provides an efficient and reliable screening assay to detect the effect of new and potential drug candidates on cardiomyocyte calcium flux, membrane depolarization, and/or the propagation of action potentials.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: June 19, 2018
    Assignee: Sanford-Burnham Medical Research Institute
    Inventors: Mark Mercola, Fabio Cerignoli, Jeffrey Price
  • Patent number: 9994915
    Abstract: Provided herein are methods for the diagnosis of human melanoma by assessing MITF, miR-211, TRPM1, and/or KCNMA1 and methods for the diagnosis of resistance to chemotherapeutic agents by assessing the regulatory pathways of PGC1?. Methods for treating melanoma, including drug-resistant melanoma, are also provided.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: June 12, 2018
    Assignee: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventor: Ranjan Perera
  • Patent number: 9982023
    Abstract: Ligand-specific HVEM variants, compositions comprising such variants, and methods of treating inflammatory diseases comprising administering such variants, are provided.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: May 29, 2018
    Assignee: Sanford-Burnham Medical Research Institute
    Inventors: Carl F. Ware, John Sedy
  • Patent number: 9969726
    Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: May 15, 2018
    Assignee: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventors: Nicholas David Peter Cosford, Dhanya Raveendra-Panickar, Douglas J. Sheffler
  • Patent number: 9957484
    Abstract: The present invention is based on the seminal discovery that several kinases play important roles in barrier pathways in somatic cell reprogramming. The present invention provides that modulating expression or activity of these kinases can significantly promote or enhance cell reprogramming efficiency. Key kinases are identified and key regulation networks involving such kinases are also identified that may be advantageously targeted to significantly increase reprogramming efficiency as well as direct differentiation of induced pluripotent stem (iPS) cells.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: May 1, 2018
    Assignee: Sanford-Burnham Medical Research Institute
    Inventor: Tariq M. Rana
  • Patent number: 9884826
    Abstract: Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the compounds described herein are useful in the treatment of conditions associated with hyper-mineralization.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: February 6, 2018
    Assignee: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventors: Anthony B. Pinkerton, Russell Dahl, Nicholas D. P. Cosford, Jose Luis Millan