Patents Assigned to Sanford-Burnham Medical Research Institute
  • Patent number: 10370245
    Abstract: Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: August 6, 2019
    Assignee: Sanford-Burnham Medical Research Institute
    Inventors: Erkki Ruoslahti, Tambet Teesalu, Kazuki Sugahara
  • Patent number: 10259844
    Abstract: Provided herein are compositions and methods for selectively targeting an endometriosis cell.
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: April 16, 2019
    Assignee: Sanford-Burnham Medical Research Institute
    Inventors: Michiko Fukuda, Daisuke Aoki, Shiro Nozawa
  • Patent number: 10227561
    Abstract: The invention provides methods, compositions and kits for the identification and enrichment of progenitor cell lines obtained from pluripotent stem cells.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: March 12, 2019
    Assignees: Mandala Biosciences, LLC, BioTime, Inc., Sanford-Burnham Medical Research Institute
    Inventors: Dana Larocca, Paola Bignone, Michael D. West, Evan Snyder
  • Patent number: 10179801
    Abstract: Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences, such as truncated LyP-1 peptides, that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: January 15, 2019
    Assignee: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventors: Erkki Ruoslahti, Tambet Teesalu, Kazuki Sugahara, Lise Roth
  • Publication number: 20180307005
    Abstract: Multifunction autofocus for automated microscopy includes automatic coarse focusing of an automated microscope by reflective positioning, followed by automatic image-based autofocusing of the automated microscope performed in reference to a coarse focus position. In some aspects, the image-based autofocusing utilizes astigmatism in microscope optics for multi-planar image acquisition along a Z axis direction of a microscope. In some other aspects, the image-based autofocusing utilizes astigmatism in microscope optics in combination with chromatic aberration for multi-planar image acquisition along the Z axis direction.
    Type: Application
    Filed: June 18, 2018
    Publication date: October 25, 2018
    Applicants: Sanford-Burnham Medical Research Institute, Vala Sciences, Inc.
    Inventors: Jeffrey H. Price, Derek N. Fuller, Albert L. Kellner, Behrad Azimi
  • Patent number: 10099993
    Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor positive allosteric modulators (PAMS), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: October 16, 2018
    Assignee: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventors: Raveendra Panickar Dhanya, Douglas J. Sheffler, Nicholas D. P. Cosford, Russell Dahl
  • Patent number: 10047119
    Abstract: Provided herein are compounds that modulate the activity of inhibitor of apoptosis proteins (IAPB), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: August 14, 2018
    Assignee: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventors: Nicholas David Peter Cosford, Mitchell Dennis Vamos
  • Patent number: 10039838
    Abstract: Disclosed are compositions and methods useful for delivering targeted therapies for pulmonary diseases, fibrotic disorders and cancer. The compositions and methods are based on peptide sequences that selectively bind to and home to diseased tissue and enable targeted therapies to effect a beneficial therapeutic result. The disclosed targeting is useful for delivering therapeutic and detectable agents to diseased tissue in an animal.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: August 7, 2018
    Assignees: Vascular Biosciences, Sanford-Burnham Medical Research Institute
    Inventors: Masanobu Komatsu, David Mann, Erkki Ruoslahti
  • Patent number: 10001470
    Abstract: The present invention provides a method, system and composition for screening drug candidates for cardiotoxicity and for novel drugs that effect cardiomyocyte contractility and function. The invention provides an efficient and reliable screening assay to detect the effect of new and potential drug candidates on cardiomyocyte calcium flux, membrane depolarization, and/or the propagation of action potentials.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: June 19, 2018
    Assignee: Sanford-Burnham Medical Research Institute
    Inventors: Mark Mercola, Fabio Cerignoli, Jeffrey Price
  • Patent number: 10001622
    Abstract: Multifunction autofocus for automated microscopy includes automatic coarse focusing of an automated microscope by reflective positioning, followed by automatic image-based autofocusing of the automated microscope performed in reference to a coarse focus position. In some aspects, the image-based autofocusing utilizes astigmatism in microscope optics for multi-planar image acquisition along a Z axis direction of a microscope. In some other aspects, the image-based autofocusing utilizes astigmatism in microscope optics in combination with chromatic aberration for multi-planar image acquisition along the Z axis direction.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: June 19, 2018
    Assignees: Sanford Burnham Medical Research Institute, Vala Sciences, Inc.
    Inventors: Jeffrey H. Price, Derek N. Fuller, Albert L. Kellner, Behrad Azimi
  • Patent number: 9994915
    Abstract: Provided herein are methods for the diagnosis of human melanoma by assessing MITF, miR-211, TRPM1, and/or KCNMA1 and methods for the diagnosis of resistance to chemotherapeutic agents by assessing the regulatory pathways of PGC1?. Methods for treating melanoma, including drug-resistant melanoma, are also provided.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: June 12, 2018
    Assignee: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventor: Ranjan Perera
  • Patent number: 9982023
    Abstract: Ligand-specific HVEM variants, compositions comprising such variants, and methods of treating inflammatory diseases comprising administering such variants, are provided.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: May 29, 2018
    Assignee: Sanford-Burnham Medical Research Institute
    Inventors: Carl F. Ware, John Sedy
  • Patent number: 9969726
    Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: May 15, 2018
    Assignee: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventors: Nicholas David Peter Cosford, Dhanya Raveendra-Panickar, Douglas J. Sheffler
  • Patent number: 9957484
    Abstract: The present invention is based on the seminal discovery that several kinases play important roles in barrier pathways in somatic cell reprogramming. The present invention provides that modulating expression or activity of these kinases can significantly promote or enhance cell reprogramming efficiency. Key kinases are identified and key regulation networks involving such kinases are also identified that may be advantageously targeted to significantly increase reprogramming efficiency as well as direct differentiation of induced pluripotent stem (iPS) cells.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: May 1, 2018
    Assignee: Sanford-Burnham Medical Research Institute
    Inventor: Tariq M. Rana
  • Patent number: 9884826
    Abstract: Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the compounds described herein are useful in the treatment of conditions associated with hyper-mineralization.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: February 6, 2018
    Assignee: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventors: Anthony B. Pinkerton, Russell Dahl, Nicholas D. P. Cosford, Jose Luis Millan
  • Patent number: 9878050
    Abstract: Provided are compositions and methods for delivery of therapeutic agents, such as chemically stabilized antisense oligonucleotides useful in RNA silencing. The compositions include interfering nanoparticles (iNOPs) associated with one or more agents. Several functional iNOP derivatives are provided which allow for targeted delivery of agents to specific cell types as well as exhibiting reduced cellular toxicity.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: January 30, 2018
    Assignee: Sanford-Burnham Medical Research Institute
    Inventor: Tariq M. Rana
  • Patent number: 9868707
    Abstract: Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: January 16, 2018
    Assignees: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE, DUKE UNIVERSITY
    Inventors: Anthony Pinkerton, Patrick Maloney, Paul Hershberger, Satyamaheshwar Peddibhotla, Michael Hedrick, Lawrence Barak, Marc Caron
  • Publication number: 20170342088
    Abstract: In certain aspects, the invention provides a method for treating a disease or condition in a subject, the method comprising co-administering to a subject in need thereof a therapeutically effective amount of at least one ULK1-inhibiting pyrimidine, and a therapeutically effective amount of an mTOR inhibitor.
    Type: Application
    Filed: August 25, 2015
    Publication date: November 30, 2017
    Applicants: SALK INSTITUTE FOR BIOLOGICAL STUDIES, SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE, YALE UNIVERSITY
    Inventors: REUBEN J. SHAW, DANIEL F. EGAN, NICHOLAS COSFORD, BENJAMIN TURK, MITCHELL VAMOS, DHANYA RAVEENDRA PANICKAR, MATTHEW CHUN, DOUG SHEFFLER
  • Patent number: 9783576
    Abstract: Disclosed are compositions and methods for selectively targeting an endometriosis cell. Also disclosed are compositions and methods for treating endometriosis.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: October 10, 2017
    Assignee: Sanford-Burnham Medical Research Institute
    Inventors: Michiko Fukuda, Kazuhiro Sugihara
  • Patent number: 9776979
    Abstract: Provided herein are small molecule Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) modulator compounds, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds. EBI2 is a therapeutic target for the treatment of a variety of diseases or conditions. In some embodiments, EBI2 is a therapeutic target for the treatment of diseases or conditions such as, but not limited to, autoimmune diseases or conditions, cancer, and cardiovascular disease.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: October 3, 2017
    Assignee: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventors: Anthony B. Pinkerton, Robert Ardecky, Eduard A. Sergienko, Marcos Gonzalez-Lopez, Santhi Reddy Ganji, Jiwen Zou