Abstract: Cells and methods of using these cells for expressing a transgene expressing a protein that is aberrantly expressed in a metabolic disorders from a safe harbor locus.
Type:
Grant
Filed:
December 4, 2013
Date of Patent:
February 9, 2016
Assignees:
Sangamo BioScience, Inc., The Children's Hospital of Philadelphia
Abstract: Nucleases and methods of using these nucleases for expressing a transgene from a safe harbor locus in a secretory tissue, and clones and animals derived therefrom.
Abstract: Disclosed is a method for the administration of zinc finger proteins (ZFPs) or nucleic acids that encode such ZFPs for treating peripheral arterial disease, particularly by the repeated administration at regular intervals if such ZFPs or nucleic acids that encode such ZFPs.
Type:
Application
Filed:
February 9, 2007
Publication date:
December 10, 2009
Applicant:
Sangamo BioScience, Inc.
Inventors:
Patrice Tremble, Joe Rokovich, Brian Annex
Abstract: The present invention provides methods of regulating gene expression using recombinant zinc finger proteins, for functional genomics and target validation applications.