Abstract: Disclosed herein are systems and methods for interactive guided personalized/personalizable patient disease management system. The system offers ongoing personalized education in response to user inputs which may include a patient's electronic health record, diagnostic codes, billing codes, and/or medical history, the ability to monitor a patient's progress throughout their treatment plan which is initially provided by the system and a patient support community for boosting patient treatment plan compliance through ongoing monitoring and personal coaching. The systems and methods provide personalized relevant diagnostic, prognostic, prevention and/or treatment information output which are curated to manage the patient's needs.