Patents Assigned to sanofi-aventis
  • Patent number: 11028123
    Abstract: The present invention relates to a method for the synthesis of a polypeptide comprising a pre-determined amino acid sequence. The method according to the invention comprises coupling cycles of coupling an N-terminally protected amino acid building block C-terminally at an unprotected N-terminal amino group of an amino acid chain, wherein at least one coupling cycle comprises a coupling step (a), a capping step (b), and a de-protecting step (c).
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: June 8, 2021
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Bernd Henkel, Tobias Metzenthin, Manfred Gerken, Wolfgang Fiedler
  • Patent number: 11027068
    Abstract: The disclosure relates to a syringe support for supporting an axial position of a syringe relative to a housing of an autoinjector. The syringe support includes a supporting beam arranged on the syringe support and biased radially inwards. The supporting beam is adapted to axially bias the syringe in a distal direction within the housing. The disclosure further relates to an autoinjector.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: June 8, 2021
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Carsten Mosebach, Thomas Mark Kemp
  • Patent number: 11020529
    Abstract: In one aspect the present disclosure relates to a sensor for measuring at least one physical or chemical parameter of a cartridge filled with a liquid substance. In a further aspect the disclosure relates to a drug delivery device equipped with such a sensor, wherein the sensor includes a planar flexible foil having a first section and having a second section separated from the first section, at least one measurement electrode located on the flexible foil, wherein the flexible foil is wrappable into a wrapped configuration in which the foil forms at least a first wrap with an inner diameter that is equal to or larger than an outer diameter of the cartridge, wherein in the wrapped configuration the first section and the second section at least partially overlap, at least one fastener located in one of the first and second section and configured to attach to the other one of the first and second sections for keeping the flexible foil in the wrapped configuration.
    Type: Grant
    Filed: July 26, 2016
    Date of Patent: June 1, 2021
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Michael Schabbach, Christian Nessel, Daniel Auernhammer, Beate Franke, Francisco Soares
  • Patent number: 11020533
    Abstract: A data collection device for attachment to an injection device, such as an injector pen, includes a sensor arrangement to detect movement of a movable component of the injection device relative to the data collection device during delivery of a medicament by the injection device, and a processor arrangement configured to, based on said detected movement, determine a medicament dosage administered by the injection device. The processor arrangement may monitor the time that has elapsed since the medicament dosage was administered, and control a display to show the medicament dosage and elapsed time to provide a memory aid to the user. In an example embodiment, the sensor arrangement includes an optical encoder and the movable component includes a plurality of light barrier formations. The movable component may be a number sleeve that provides a visual indication of a dose programmed into the injection device.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: June 1, 2021
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Frank Erbstein, Paul Richard Draper, Robert Frederick Veasey, David Aubrey Plumptre, Joseph Butler
  • Patent number: 11016080
    Abstract: The present invention refers to a medical device (100) comprising: •a measurement unit (110) adapted to measure a value of a physiological parameter, for example a blood glucose level, •a data storage (130) adapted to store ?a plurality of measurement values of the physiological parameter, ?for each measurement value an associated event tag, ?for each measurement value an associated time stamp, ?for each at least one predefined event an associated current time range for tagging preselection, •a processor (140) adapted to ?receive from the measurement unit (110) or from the data storage (130) a new measurement value with an associated time, ?comparing the associated time stamp of the new measurement value with the stored at least one time range for tagging preselection, ?if the time stamp is within one current time range for tagging preselection the corresponding tag of the predefined event is preselected and initiated for user confirmation, ?in case one particular predefined tag of one particular predefined e
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: May 25, 2021
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Mario Esser
  • Patent number: 11013863
    Abstract: The present disclosure pertains to an assembly for a drug delivery device having a housing part, a piston rod displaceable relative to the housing part, a first sleeve member and a second sleeve member. First and second sleeve members are coupled to the housing part. In an initial state of the assembly the first sleeve member is movable from an initial position to a second position relative to the second sleeve member which allows the piston rod to axially travel from an initial position to a predetermined second position such that the assembly is in a primed state. Moreover, in the primed state of the assembly, with the first sleeve member being in the second position relative to the second sleeve member, first and second sleeve members are permanently rotationally and axially locked to each other by a first engagement feature such that first and second sleeve members together form a sleeve.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: May 25, 2021
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: David Aubrey Plumptre, Paul Richard Draper, David Richard Mercer, Naceur Rekaya, Paul Griffin
  • Patent number: 11017891
    Abstract: A medical device data management unit includes a data storage and a processor. The data storage stores multiple measurement values of a physiological parameter of a user including a blood glucose level, multiple applied medicament dose values, time information associated with the multiple measurement values of the physiological parameter and one or more target ranges of the physiological parameter. The processor can determine a suggestion for a subsequent medicament dose value, check a prior suggestion and adjust the suggestion based on other measured values. The data management unit can be included in a medical device. The instructions to operate the data management unit can be encoded on a computer-readable medium.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: May 25, 2021
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Andrew Tubb
  • Patent number: 11007322
    Abstract: In one aspect, the present disclosure relates to a sensor for measuring at least one physical or chemical parameter of a cartridge or syringe filled with a liquid substance. In further aspects the disclosure relates to a cartridge equipped with such a sensor and a drug delivery device equipped with such a cartridge. The sensor comprises a planar flexible foil arrangeable to an outer circumference of a barrel of the cartridge or syringe. The sensor also includes at least a first and a second measuring electrode is arranged on the foil and at least a first and a second contact electrode is arranged on the foil. The sensor further comprises, processor connected to the first and to the second measurement electrodes and a transceiver arranged on the foil. The transceiver is also and connected to the processor. Additionally, the first contact electrode and the second contact electrode are connected to the processor.
    Type: Grant
    Filed: July 26, 2016
    Date of Patent: May 18, 2021
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Michael Schabbach, Christian Nessel, Daniel Auernhammer, Francisco Soares, Beate Franke
  • Patent number: 11007323
    Abstract: The present disclosure relates to a medicament injection device comprising a housing, a cartridge holder mounted in the housing and configured to receive a cartridge containing a medicament, an injection needle having a proximal end and a distal end, an injection needle holder to which the injection needle is fixed. The medicament injection device comprises an actuating mechanism for pivoting the injection needle holder relative to the cartridge holder between a storage position in which, when the cartridge is received in the cartridge holder, the distal end of the injection needle is spaced from the cartridge, and a use position in which, when the cartridge is received in the cartridge holder, the distal end of the injection needle can engage the cartridge.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: May 18, 2021
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Marc Schader, Michael Helmer, Peter Nober
  • Patent number: 11000649
    Abstract: An assembly for a drug delivery device is provided comprising a housing, and a lead screw having a longitudinal axis, a distal end and a proximal end, the lead screw being rotatably fixed during dose setting and dose delivery and axially movable in a distal direction relative to the housing, the lead screw further including a thread. The assembly further comprises a drive nut threadedly engaged with and screwable along the lead screw thread and a dial link connected with the drive nut and axially movable and rotatably fixed relative to the drive nut, where the dial link comprises a first portion of a feedback ratchet. The assembly is configured such that, during dose delivery, the assembly generates a feedback signal.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: May 11, 2021
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Stefan Blancke, Axel Teucher, Michael Jugl, Christiane Schneider
  • Patent number: 10973980
    Abstract: A dose indicating mechanism for a drug delivery device is configured for delivery of a medicament contained in a single medicament cartridge, the medicament comprising at least a first drug and a second drug, wherein the dose indicating mechanism comprises a body, a dose dial component configured to move relative to the body during dose setting and a first dose indicator configured to display a set dose of the medicament, the first drug, or the medicament and the first drug depending on displacement of the dose dial component during the dose setting. In order to provide a user with further information, a second dose indicator is provided that is configured to display a set dose of the second drug during the dose setting. The disclosure is also directed to a respective drug delivery device.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: April 13, 2021
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Michael Schabbach
  • Patent number: 10973981
    Abstract: The present invention relates to a housing of a medical device and to a respective medical device, wherein the housing comprises a body to receive at least one device component and wherein the body is flexibly deformable in response to mechanical impact above a predefined threshold.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: April 13, 2021
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Michael Jugl, Axel Teucher
  • Patent number: 10973983
    Abstract: The present disclosure relates to a drug delivery device comprising: a housing; a moveable number sleeve disposed within the housing and having numbers printed thereon; and a transparent window occupying an aperture of the housing and covering the number sleeve such that the number sleeve is visible through the transparent window. At least one region of the housing located adjacent to the transparent window is transparent to visible light and is in optical communication with the transparent window.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: April 13, 2021
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Roman Prager
  • Patent number: 10975434
    Abstract: The present invention relates to metformin for use in treating a patient, wherein the patient exhibits an increased level of GDF15 in response to metformin treatment; to methods of identifying a patient who will benefit or who will not benefit from metformin treatment; methods of treating a patient at risk of developing or suffering from a disease or disorder comprising administering therapeutically effective amount of metformin; methods of adapting the dosage of metformin; the usage of GDF15 as biomarker for identifying a patient who will benefit or who will not benefit from metformin treatment, kits for use in identifying a patient who will benefit from metformin treatment and the use of the kits, as well as methods of treating a patient or who will not benefit from metformin treatment.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: April 13, 2021
    Assignees: Sanofi-Aventis Deutschland GmbH
    Inventors: Sibylle Hess, Thorsten Sadowski, Hertzel Gerstein, Guillaume Pare, Gregory Steinberg
  • Patent number: 10973989
    Abstract: An auto-injector comprising an elongate housing containing a syringe. The housing having an orifice intended to be applied against an injection site. The syringe is slidably arranged with respect to the housing. A spring pushing the needle from a covered position into an advanced position, operating the syringe and covering the needle. An activator arranged to lock the spring prior to manual operation and capable of, upon manual operation, releasing the spring means for injection. A first gear arrangement and a second gear arrangement arranged fro converting torque from a first end and a second end of the torsion spring into a translative force. The first end groundable in the housing while the second end acts on a plunger through the second gear arrangement for advancing the needle and supplying the dose.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: April 13, 2021
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Thomas Mark Kemp, Timothy Donald Barrow-Williams, Matthew Ekman
  • Patent number: 10973987
    Abstract: The present disclosure relates to a drug delivery device, including: a body adapted to retain a medicament cartridge, a cap attachable to a distal end of the body to cover an opening thereof, an activation mechanism arranged within the body, wherein the cap includes an activation feature adapted to be inserted into an activation opening of the body in order to actuate the activation mechanism or allow actuation thereof.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: April 13, 2021
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Stefan Wendland, Michael Harms
  • Patent number: 10967126
    Abstract: The present disclosure relates to an apparatus and a method. The apparatus comprises a body part and a cover part, wherein the body part and the cover part are configured to at least partially form a fluid channel between a surface of the body part and a surface of the cover part. The surfaces of the body part and the cover part may be facing surfaces. The method comprises manufacturing the apparatus according to the present disclosure.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: April 6, 2021
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Marc Holtwick, James Alexander Davies, Simon Lewis Bilton, David Moore, Steven Wimpenny, Christopher Nigel Langley
  • Patent number: 10960145
    Abstract: A drug delivery device for setting and dispensing a dose of a drug is presented having a support body having a first end defining a first opening and a second end defining a second opening and a centered outer indicator ring. A syringe barrel sealed by a stopper is slidably diposed therein along an axial direction and adapted to have an integrated needle or to be coupled with a needle assembly, wherein the syringe barrel is positioned within the support body. A needle shield is adapted to be coupled to one of the ends of the support body and slidably disposed thereon. An outer body is adapted to be coupled to the other end of the support body and slidably disposed thereon, wherein the outer indicator ring limits the movement of the outer body as well as of the needle shield.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: March 30, 2021
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Michael Harms, Verena Hofmann, Gareth Roberts, Chris Ward, Graham Wilson
  • Patent number: 10960142
    Abstract: A detent mechanism for controlling translation between two components in a longitudinal direction includes a resilient beam on one of the components and a rhomboid ramp member on the other component. The resilient beam is essentially straight when relaxed and has a first beam head and is arranged to interact in a ramped engagement with respectively one of two ramps. Each ramp is on one longitudinal side of the rhomboid ramp member such that application of a translative force between the components in one longitudinal direction with the first beam head engaged to one of the ramps in a first state deflects the resilient beam in one transversal direction and such that application of a translative force between the components in the other longitudinal direction with the first beam head engaged to the other one of the ramps deflects the resilient beam in the other transversal direction.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: March 30, 2021
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Simon Francis Brereton, Thomas Kemp, Rosie Burnell, Matthew Ekman
  • Patent number: D916277
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: April 13, 2021
    Assignees: Sanofi-Aventis Deutschland GMBH, Regeneron Pharmaceuticals, Inc.
    Inventors: Courtney Nicholas, Scott Barton, Alex Zuyev, Bart Burgess, Alexei Goraltchouk