Patents Assigned to Sanofi-Aventis Deutschland GmbH
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Patent number: 11826552Abstract: The disclosure relates to an activating mechanism for a medicament delivery device, wherein the activating mechanism includes a cartridge containing a dosage of a medicament, a cartridge carrier holding the cartridge and comprising a distal carrier section, a hollow injection needle arranged within a distal end of the cartridge carrier comprising an inner needle section targeted inside the cartridge carrier, whereby the inner needle section is spaced from the cartridge in a distal direction (D) when the medicament delivery device is in an initial position (P1), a removable needle cap to cover and seal an outer needle section of the injection needle that is targeted outside the cartridge carrier.Type: GrantFiled: March 3, 2020Date of Patent: November 28, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventor: Michael Helmer
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Patent number: 11819670Abstract: An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.Type: GrantFiled: December 18, 2020Date of Patent: November 21, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventors: Simon Francis Brereton, Thomas Kemp, Rosie Burnell, Matthew Ekman
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Patent number: 11813436Abstract: Auto-injector for administering a dose of a liquid medicament includes a housing to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament, the housing having a distal end and a proximal end with an orifice to apply against an injection site. A spring means, upon activation, can push the needle from inside the housing through the orifice and past the proximal end, operate the syringe to supply the dose of medicament, and retract the syringe with the needle after delivering the medicament. An activating means can lock the spring means in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means for injection.Type: GrantFiled: May 8, 2023Date of Patent: November 14, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventors: Matthew Ekman, Yannick Hourmand, Timothy Donald Barrow-Williams
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Patent number: 11813437Abstract: A sensor device to be attached to a drug delivery device includes an array of conducting elements each forming part of a respective resonant circuit and each operable to have a signal applied to it. The drug delivery device has a first movable element supporting a conductive region, which is configured to move along a path parallel to a longitudinal axis of the drug delivery device. When the sensor device is attached to the drug delivery device, the conducting elements are arranged such that each resonant circuit is operable to output a signal indicative of the proximity of the conductive region supported on the first moveable element to the respective conducting element of each resonant circuit. The sensor device includes circuitry to receive the signals output from the resonant circuit and, based on the received signals, determines information associated with a location along the path of the first movable element.Type: GrantFiled: February 22, 2021Date of Patent: November 14, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventors: Thomas Klemm, Dmitri Bogatirsky, Mihaly Gabli, Stefan Bohling
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Patent number: 11813438Abstract: The invention relates to a disposable drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing, a cartridge holder for retaining a cartridge containing the medicament, a piston rod displaceable relative to the cartridge holder, a driver coupled to the piston rod, a display member for indicating a set dose and being coupled to the housing and to the driver, and a button coupled to the display member and to the driver.Type: GrantFiled: May 16, 2019Date of Patent: November 14, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventor: David Aubrey Plumptre
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Patent number: 11807905Abstract: The present invention relates to metformin for use in treating a patient, wherein the patient exhibits an increased level of GDF15 in response to metformin treatment; to methods of identifying a patient who will benefit or who will not benefit from metformin treatment; methods of treating a patient at risk of developing or suffering from a disease or disorder comprising administering therapeutically effective amount of metformin; methods of adapting the dosage of metformin; the usage of GDF15 as biomarker for identifying a patient who will benefit or who will not benefit from metformin treatment, kits for use in identifying a patient who will benefit from metformin treatment and the use of the kits, as well as methods of treating a patient or who will not benefit from metformin treatment.Type: GrantFiled: March 11, 2021Date of Patent: November 7, 2023Assignees: Sanofi-Aventis Deutschland GmbHInventors: Sibylle Hess, Thorsten Sadowski, Hertzel Gerstein, Guillaume Pare, Gregory Steinberg
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Patent number: 11801347Abstract: A cartridge carrier assembly for a medicament delivery device comprises a cartridge carrier adapted to receive a cartridge defining a cavity containing a dose of a medicament, a needle hub being part of the cartridge carrier or coupled to the cartridge carrier such that the needle hub is fixed relative to the cartridge carrier, the needle hub adapted to receive a distal end or part of the cartridge, an injection needle having a tipped proximal needle section adapted to pierce a sealing element distally arranged on the cartridge, and a removable needle cap attachable to a distal end of the cartridge carrier. The needle hub comprises a cartridge retention feature adapted to abut the cartridge or a part thereof to limit axial movement of the cartridge in the distal direction such that the proximal needle section is spaced from the sealing element.Type: GrantFiled: September 4, 2020Date of Patent: October 31, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventor: Michael Helmer
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Patent number: 11802787Abstract: In one aspect the present disclosure relates to a sensor for measuring at least one physical or chemical parameter of a cartridge or syringe filled with a liquid substance. In further aspects the disclosure relates to a cartridge equipped with such a sensor as well as to a drug delivery device equipped with such a cartridge, wherein the sensor comprises: a planar flexible foil arrangeable to an outer circumference of a barrel of the cartridge or syringe, at least a first and a second measuring electrode arranged on said foil, and at least a first and a second contact electrode arranged on said foil, wherein the first contact electrode is connected to the first measuring electrode and wherein the second contact electrode is connected to the second measuring electrode.Type: GrantFiled: December 9, 2020Date of Patent: October 31, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventors: Michael Schabbach, Christian Nessel, Daniel Auernhammer, Beate Franke, Francisco Soares
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Patent number: 11793943Abstract: The present disclosure relates to a needle arrangement for a drug delivery device. The needle arrangement includes a distal needle tip and a proximal needle tip. The distal needle tip is held in a distal needle holder and wherein the proximal needle tip is held in a proximal needle holder. The distal needle tip and the proximal needle tip are in fluid communication with each other through a fluid channel. The fluid channel is adapted to allow axial movement of the distal needle tip and relative to the proximal needle tip between a compact state and an extended state. A length of the needle arrangement over the distal needle tip and the proximal needle tip in the extended state is greater than in the compact state.Type: GrantFiled: October 30, 2017Date of Patent: October 24, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventor: Stefan Wendland
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Patent number: 11786657Abstract: The invention relates to an arrangement for detecting a position of a plunger (4) relative to a bung (3) in a drug cartridge (1), comprising a proximity sensor (5) located close to a distal end (6) of the plunger (4) facing the bung (3) and aligned to receive light reflected by the bung (3).Type: GrantFiled: August 11, 2021Date of Patent: October 17, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventors: Paul Richard Draper, Anthony Paul Morris, Stephen Francis Gilmore
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Patent number: 11779709Abstract: A supplemental device for attachment to an injection device, the supplemental device having a housing containing at least two electromechanical switches each having an open state and a closed state and a protrusion associated with each switch configured to protrude from the housing so as to contact a rotatable surface of the injection device while the supplemental device is attached to the injection device; and a processor arrangement configured to detect a change in the state of each of the switches; and to determine a direction of rotation of the rotatable surface of the injection device from the detected state changes.Type: GrantFiled: April 25, 2022Date of Patent: October 10, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventors: Robert Veasey, David Aubrey Plumptre, Paul Richard Draper, David Richard Mercer
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Patent number: 11771838Abstract: The present disclosure relates to an audible indicator for use with a drug delivery device comprising a resilient force member configured to reside in one of a relaxed state and a biased state. The audible indicator comprises a retainer adapted to maintain the resilient force member in the biased state. The resilient force member releases stored energy to impact a surface to generate an audible signal when the resilient force member changes from the biased state into the relaxed state.Type: GrantFiled: August 23, 2017Date of Patent: October 3, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventors: Michael Helmer, Marc Schader
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Patent number: 11759568Abstract: An injection device comprises an injector body having at least one indicator aperture; a medicament reservoir disposed within the injector body; a piston; and one or more status indicators. A movement of the piston expels a medicament out of the medicament reservoir, and operates to move at least one of the one or more status indicators relative to a corresponding indicator aperture.Type: GrantFiled: November 16, 2020Date of Patent: September 19, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventor: Marcus-Meinolf Dittrich
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Patent number: 11759575Abstract: An injection device includes an elongated housing extending along a longitudinal axis, a piston rod to operably engage with a piston of a cartridge filled with the medicament, a dose tracker selectively operably engageable with the piston rod, wherein the dose tracker is longitudinally displaceable relative to the housing from an initial position in a proximal direction towards at least a first activation position for setting of the dose and wherein the dose tracker is longitudinally displaceable relative to the housing in a distal direction from the at least first activation position towards the initial position for dispensing of the dose, a spring to urge the dose tracker in the proximal direction relative to the housing, an interlock to lock the dose tracker in the initial position relative to the housing, and a release member to release the interlock.Type: GrantFiled: November 5, 2018Date of Patent: September 19, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventors: Michael Helmer, Michael Schabbach, Julian Kersting
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Patent number: 11752264Abstract: An auto-injector device comprises a stopper for expelling a medicament out of a medicament reservoir; a driving element which has a first configuration and a second configuration and is configured to change shape from the first configuration to the second configuration when the temperature of the driving element is raised above a shape change temperature, so as to drive the stopper of the syringe mechanism through the medicament reservoir; and a heating mechanism configured to actively heat the driving element. The heating mechanism is a chemical heating element configured to generate heat through an exothermic process or comprises a fluid reservoir for retaining a fluid; a heater configured to heat the fluid in the fluid reservoir; a pump configured to expel the fluid out of the fluid reservoir; and a connecting conduit arranged to carry the fluid from the fluid reservoir to the driving element.Type: GrantFiled: November 16, 2020Date of Patent: September 12, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventors: Stefan Wendland, Michael Harms
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Patent number: 11752266Abstract: The disclosure relates to a syringe support for supporting an axial position of a syringe relative to a housing of an autoinjector. The syringe support comprises a projecting portion, which projects from the syringe support in a distal direction and a flexible portion which axially adjoins the projecting portion. The flexible portion is adapted to axially bias the syringe in the distal direction within the housing. The disclosure further relates to an autoinjector.Type: GrantFiled: February 6, 2023Date of Patent: September 12, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventors: Thomas Mark Kemp, Louise Hodgson
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Patent number: 11752273Abstract: Described is a medicament delivery device (1), comprising a body (2), a container carrier (7) for retaining a medicament container within the body (2) and being slidably disposed in the body (2), a sleeve (6) slidably coupled to body (2), and a piston rod (11) coupled to the body (2) and the container carrier (7). The piston rod (11) and the container carrier (7) provide a feedback as 10 the container carrier (7) moves from a first position (P1) to a second position (P2) relative to the body (2).Type: GrantFiled: January 9, 2023Date of Patent: September 12, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventors: Winfried Huthmacher, Peter Nober
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Patent number: 11744955Abstract: The present disclosure relates to a sheath remover for removing a protective needle sheath from a drug cartridge. The sheath remover includes a resilient ring and one or more resilient legs attached to the ring and extending in a proximal direction. Each leg includes an inwardly directed ledge arranged at a proximal end of the leg. The ring consists of a resilient material allowing inward deflection of a proximal end of the ring. The present disclosure further relates to a method for assembling and a method for using the sheath remover.Type: GrantFiled: January 10, 2023Date of Patent: September 5, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventor: Winfried Huthmacher
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Patent number: 11744952Abstract: The present invention relates to injectors, such as pen-type injectors, that provide for administration of medicinal products from a multidose cartridge and permit a user to set a delivery dose. An injector may include a housing, a cartridge containing a medicinal product, the cartridge being retained within the housing, means for selecting a dose of the medicinal product to be expelled, and means for expelling the selected dose of the medicinal product. The housing may be a unitary housing within which the means for selecting the dose and the means for expelling the selected dose are moveably retained. Alternatively, the injector may include a housing, a piston rod, an insert located in the housing and through which the piston rod may rotate, ratchet means, a dose dial sleeve, a drive sleeve, a button located on the drive sleeve and rotatable with respect to the drive sleeve, and clutch means which upon depression of the button prevents rotation between the dose dial sleeve and the drive sleeve.Type: GrantFiled: October 15, 2021Date of Patent: September 5, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventors: Robert Frederick Veasey, Christopher Nigel Langley, Steven Wimpenny
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Patent number: 11730891Abstract: A data collection device comprises: a first portion having one or more features configured for attaching of the first portion to a dosage knob of an injection device; a second portion rotatably coupled with the first portion, wherein at least part of the second portion is movable axially relative to the first portion; a sensor arrangement configured to detect rotation of the first portion relative to the second portion; and a processor arrangement configured to, based on said detected movement, determine a medicament amount expelled by the injection device, wherein the coupling arrangement is configured to provide a non-permanent coupling between the first portion and the dosage knob of the injection device.Type: GrantFiled: July 24, 2020Date of Patent: August 22, 2023Assignee: Sanofi-Aventis Deutschland GMBHInventors: Maurice Toporek, Matthias Felber, Christoph Matthias Gugl, Marcus-Meinolf Dittrich, Christian Nessel, Stephan Riedel, Armin Koller, Alexander Heinrich, Florian Eberli, Philipp Muller, Sven Zwicker