Abstract: The present disclosure provides methods for treating multiple myeloma (such as refractory multiple myeloma or relapsed and refractory multiple myeloma) in an individual who received at least two prior therapies for multiple myeloma. The methods comprise administering to the individual an anti-CD38 antibody, pomalidomide, and dexamethasone. Also provided are methods of improving renal impairment in an individual having multiple myeloma.

Abstract: An apparatus and method for unloading a plurality of items from a carrier is provided. The items are preloaded in the carrier, in a column having a top row. The apparatus has a first conveyor which has a first end for approaching the top row, an opposite second end and a conveyor body connecting the first end and the second end. The first end has an end platform for receiving the top row and an arm associated with the end platform for transporting the top row onto the end platform. A second conveyor is operatively connected to the first conveyor for receiving the top row from the first conveyor and transporting the top row for further processing the top row. The apparatus also has a control unit for controlling the movement of the first conveyor and the second conveyor.

Abstract: The present invention is directed to an aqueous pharmaceutical suspension of fexofenadine zwitterionic dihydrate Form I.

Abstract: This invention relates to a method for reducing the risk of conversion to clinically definite multiple sclerosis (CDMS) in patients who have experienced their first neurological symptoms consistent with clinically isolated syndrome (CIS).

Abstract: An apparatus and method for unloading a plurality of items from a carrier is provided. The items are preloaded in the carrier, in a column having a top row. The apparatus has a first conveyor which has a first end for approaching the top row, an opposite second end and a conveyor body connecting the first end and the second end. The first end has an end platform for receiving the top row and an arm associated with the end platform for transporting the top row onto the end platform. A second conveyor is operatively connected to the first conveyor for receiving the top row from the first conveyor and transporting the top row for further processing the top row. The apparatus also has a control unit for controlling the movement of the first conveyor and the second conveyor.

Abstract: An apparatus for loading and unloading a plurality of shipping containers into a carrier. The containers are arranged according to a predetermined pattern on a fixed staging unit of the apparatus. A first conveyor of the apparatus receives and transports the arranged containers from the fixed staging unit. The first conveyor is movable horizontally. A second conveyor of the apparatus receives the containers from the first conveyor and transports the containers into the carrier. The second conveyor is movable horizontally and vertically. A control unit of the apparatus controls transportation of the containers from the second conveyor into the carrier when the second conveyor is vertically moved to a predetermined position.

Abstract: The present invention is an improved method for the preparation of (4-fluoro-3-pyridin-4-yl-benzyl)-carbamic acid tert-butyl ester, compound of formula I. The invention is directed to a method of synthesis for the compound of formula I in three steps, comprising formation of 5-((tert-butoxycarbonyl)aminomethyl)-2-fluorobenzeneboronic acid (compound 11), reaction of compound 11 under Suzuki coupling conditions to yield (4-fluoro-2-pyridin-4-yl-benzyl)-carbamic acid tert-butyl ester and selective hydrogenation of the aforementioned product under hydrogenation conditions yields compound I. The invention is also directed to the intermediates 5-((tert-butoxycarbonyl)amino-methyl)-2-fluorobenzeneboronic acid (compound 11), and (4-fluoro-3-pyridin-4-yl-benzyl)-carbamic acid tert-butyl ester (compound 13).

Abstract: A package for accommodating, storing, displaying and transporting an article, such as, pharmaceutical products. The package has a receptacle mountable to a paperboard. The mountable receptacle has a clamshell for receiving, for example, one or more blister cards. The clamshell has a first portion having a first edge and a second portion having a second edge, which opposes the first edge. The mountable receptacle has an extension connected at least to the second edge through a breakable mechanism. The extension is attached to a surface of the paperboard, such that the clamshell can be detached from the paperboard by breaking the breakable mechanism.

Abstract: A package for accommodating, storing, displaying and transporting an article, such as, pharmaceutical products. The package has a receptacle mountable to a paperboard. The mountable receptacle has a clamshell for receiving, for example, one or more blister cards. The clamshell has a first portion having a first edge and a second portion having a second edge, which opposes the first edge. The mountable receptacle has an extension connected at least to the second edge through a breakable mechanism. The extension is attached to a surface of the paperboard, such that the clamshell can be detached from the paperboard by breaking the breakable mechanism.

Abstract: This invention is related to the use of the combination of teriflunomide and interferon beta thereof, for the preparation of a medicament for use in treating multiple sclerosis.

Abstract: This invention is related to the use of the combination of teriflunomide or a pharmaceutically acceptable salt thereof and glatiramer acetate for treating multiple sclerosis.

Abstract: The present invention is directed to a SPE-LC-MS-MS method for quantitatively determining risedronate in a urine sample.

Abstract: The present invention is an improved method for the preparation of 4-fluoro-3-piperidin-4-yl-benzyl)-carbamic acid tert-butyl ester, compound of formula I. The invention is directed to a method of synthesis for the compound of formula I in three steps, comprising formation of 5-((tert-butoxycarbonyl)aminomethyl)-2-fluorobenzeneboronic acid (compound 11), reaction of compound 11 under Suzuki coupling conditions to yield (4-fluoro-2-pyridin-4-yl-benzyl)-carbamic acid tert-butyl ester and selective hydrogenation of the aforementioned product under hydrogenation conditions yields compound I. The invention is also directed to the intermediates 5-((tert-butoxycarbonyl)amino-methyl)-2-fluorobenzeneboronic acid (compound 11), and (4-fluoro-2-pyridin-4-yl-benzyl)-carbamic acid tert-butyl ester (compound 13).

Abstract: This invention is related to the use of the combination of teriflunomide and interferon beta thereof, for the preparation of a medicament for use in treating multiple sclerosis.

Abstract: The disclosure provides a method for quantitatively determining risedronate in a urine sample by adding an internal standard to the urine sample, applying the urine sample to a polymeric water-wettable reverse-phased sorbent preconditioned with methanol, washing the sorbent with TEA in water and formic acid in methanol, eluting risedronate with a mixture of methanol and water containing EDTA under vacuum, evaporating the eluted solution and reconstituting with a mixture of methanol and NH4OH buffer and analyzing the sample with a LC-MS/MS system.

Abstract: An apparatus for loading and unloading a plurality of shipping containers into a carrier. The containers are arranged according to a predetermined pattern on a fixed staging unit of the apparatus. A first conveyor of the apparatus receives and transports the arranged containers from the fixed staging unit. The first conveyor is movable horizontally. A second conveyor of the apparatus receives the containers from the first conveyor and transports the containers into the carrier. The second conveyor is movable horizontally and vertically. A control unit of the apparatus controls transportation of the containers from the second conveyor into the carrier when the second conveyor is vertically moved to a predetermined position.

Abstract: Disclosed is a novel process for preparing crystalline Form II of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide.

Abstract: The present invention is an improved process for the preparation of a sodium/proton exchange inhibitor of sub-type 3 (NHE-3) useful in the treatment of sleep apnea and other related respiratory disorders.

Abstract: Disclosed are amorphous solid dispersion formulations comprising 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide.

Abstract: Disclosed are a novel crystalline form of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide, processes of preparing said crystalline form of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide, compositions comprising said form in admixture with one or more pharmaceutically acceptable excipients, and uses for the same.