Abstract: In accordance with the present invention there is provided a method of treating a mammal having a solid tumor, the method comprising:
a) administering to the mammal an effective amount of 3-ainino-1,2,4-benzotriazine 1,4-dioxide;
b) administering to the mammal an effective amount of paclitaxel; and
c) administering to the mammal an effective amount of a platinum complex. The method provides unexpected synergistic efficacy. The invention further provides a kit for treatment of a mammalian tumor comprising 3-amino-1,2,-benzotriazine 1,4-dioxide, paclitaxel and a platinum complex.
Type:
Grant
Filed:
February 16, 2000
Date of Patent:
November 20, 2001
Assignee:
Sanofi-Synthelabo Inc.
Inventors:
Daniel L. Dexter, Paul E. Juniewicz, James B. Rake, Daniel D. Von Hoff
Abstract: Disclosed are: aqueous parenteral formulations for the treatment of cancer tumors comprising 1,2,4-benzotriazine 1,4-dioxides in a citrate buffer; and method of cancer tumor treatment.
Abstract: In accordance with the present invention there is provided a method of treating a mammal having a solid tumor, the method comprising:a) administering to the mammal an effective amount of 3-amino-1,2,4-benzotriazine 1,4-dioxide;b) administering to the mammal an effective amount of paclitaxel; andc) administering to the mammal an effective amount of a platinum complex.The method provides unexpected synergistic efficacy. The invention further provides a kit for treatment of a mammalian tumor comprising 3-amino-1,2,-benzotriazine 1,4-dioxide, paclitaxel and a platinum complex.
Type:
Grant
Filed:
February 27, 1998
Date of Patent:
May 16, 2000
Assignee:
Sanofi-Synthelabo Inc.
Inventors:
Daniel L. Dexter, Paul E. Juniewicz, James B. Rake, Daniel D. Von Hoff