Patents Assigned to Sanofi
  • Process for preparation of dronedarone by removal of hydroxyl group
    Patent number: 9701654
    Abstract: The invention relates to a novel process for preparation of dronedarone of formula (I) and pharmaceutically acceptable salts thereof the hydroxyl group is removed, and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: July 11, 2017
    Assignee: SANOFI
    Inventors: Antal Friesz, Zsolt Dombrády
  • Needle assembly attachment and removal device
    Patent number: 9694143
    Abstract: Described is a needle assembly attachment and removal device comprising a case having a base and a longitudinal axis (L), a carriage axially movable with the case from a first position to a second position, a carrier rotatably coupled to the carriage and adapted to hold a needle assembly, and a gearing arrangement rotatably coupled to the carriage and adapted to rotate the carrier in a first rotational direction as the carriage moves from the first position to the second position and in a second rotational direction as the carriage moves from the second position to the first position.
    Type: Grant
    Filed: November 23, 2012
    Date of Patent: July 4, 2017
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Uwe Dasbach, Christoph Dette, Peter Nober, Fiete Sonntag, Christoph Eisengarthen
  • Heteroaryl compounds and uses thereof
    Patent number: 9695132
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: July 4, 2017
    Assignees: Celgene CAR LLC, Sanofi
    Inventors: Laura Akullian D'Agostino, Robert Tjin Tham Sjin, Deqiang Niu, Joseph John McDonald, Zhendong Zhu, Haibo Liu, Hormoz Mazdiyasni, Russell C. Petter, Juswinder Singh, Matthieu Barrague, Alexandre Gross, Mark Munson
  • Needle safety device
    Patent number: 9694141
    Abstract: Described is a needle safety device comprising a needle hub including a plurality of resilient arms having detents, a needle having a distal tip, and a needle shield telescopically coupled to the needle hub. The needle shield includes a plurality of axial slots adapted to engage the detents on the resilient arms and the detents are axially movable in the slots. The needle shield includes a plurality of grooves separated from the slots by separation walls and the grooves are adapted to engage the detents. When the needle shield is in a first position relative to the needle hub, the needle shield covers the distal tip of the needle and the detents are engaged in the slots. When the needle shield is in a second position relative to the needle hub, the distal tip of the needle protrudes through an aperture in the needle shield and the detents are engaged in the slots.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: July 4, 2017
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: John Slemmen, Chris Ward
  • Peristaltic pump
    Patent number: 9695813
    Abstract: A peristaltic pump comprises a tube to transport a material in a transport direction and a conveying screw, which is configured to cause a transport of the material by causing a successive squeezing of the tube along the transport direction.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: July 4, 2017
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Philippe Nzike, Michael Schabbach, Olaf Zeckai, Meinolf Werner, Ole Simonowsky
  • Safety device for a pre-filled syringe, injection device and injection kit
    Patent number: 9694138
    Abstract: According to the invention, a safety device for a pre-filled syringe comprises a hollow support body to retain the pre-filled syringe therein, a hollow needle shield that is slidable relative to the support body and guiding means for guiding the movement of the needle shield relative to the support body. The guiding means comprise a guide pin, a guide track and a cut-out adjacent to the guide track. The guide pin protrudes into the guide track and moves within and along the guide track when the needle shield is slid relative to the support body. The cut-out allows a side wall of the guide track to be deflected in a lateral direction perpendicular to a central axis of the safety device.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: July 4, 2017
    Assignee: Sanofi-Anetis Deutschland GMBH
    Inventors: Matthew Ekman, Christopher James Smith, Troy Baker, Graham Wilson, Gareth Roberts, John Slemmen
  • Sampling module device and method
    Patent number: 9694144
    Abstract: A medicament injection device includes a device body portion that includes a penetrating member channel. A penetrating member is provided with a sharpened distal tip and shaft portion that is slidably disposed within the penetrating channel to provide for a penetrating to travel in a linear axial movement. A pierceable membrane isolates a penetrating member in an associated penetrating member chamber. A medicament reservoir is in fluid communication with the penetrating member. The medicament reservoir is configured to house a medicament and is coupled to the penetrating member to allow for delivery of medicament to a tissue site.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: July 4, 2017
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventor: Dominique M. Freeman
  • Dual GLP-1/glucagon receptor agonists
    Patent number: 9694053
    Abstract: The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: July 4, 2017
    Assignee: SANOFI
    Inventors: Torsten Haack, Michael Wagner, Bernd Henkel, Siegfried Stengelin, Andreas Evers, Martin Bossart, Dieter Kadereit
  • Detent mechanism
    Patent number: 9687607
    Abstract: The invention relates to a detent mechanism for controlling translation between two components in a longitudinal direction (P, D), the detent mechanism comprising at least one clip on one of the components arranged to be in a ramped engagement with a recess in the other one of the components in an initial state in such a manner that translation between the components is constrained and that application of a translative force between the components in one longitudinal direction (P, D) with the clip engaged with the recess deflects the clip out of the recess when a predetermined value of the translative force, at least depending on the resilience of the clip, is overcome so as to allow translation between the components.
    Type: Grant
    Filed: February 16, 2012
    Date of Patent: June 27, 2017
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Simon Francis Brereton, Thomas Kemp, Rosie Burnell, Matthew Ekman
  • Dose setting mechanism and drug delivery device
    Patent number: 9687612
    Abstract: A dose setting mechanism that prevents dispensing of a drug when an incorrect cartridge assembly is attached to the dose setting mechanism. Dispense of a drug may be allowed by preventing rotation of a spindle nut of a drug delivery device, and dispense of a drug may be prevented by not preventing rotation of the spindle nut. Preventing dispense of a drug may be accomplished by preventing rotation of the spindle when an incorrect cartridge assembly is inserted. Preventing dispense of a drug may be accomplished by preventing the spindle from applying an axial force on the cartridge when an incorrect cartridge assembly is inserted.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: June 27, 2017
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Richard James Vincent Avery, Paul Richard Draper, Aled Meredydd James
  • Mounting arrangement and coupling assembly for a drug-delivery device
    Patent number: 9687608
    Abstract: A mounting arrangement for a drug-delivery device is proposed, the mounting arrangement comprising: a plug element with a longitudinal axis (L) and a housing part having a recess with a side wall which is adapted to receive the plug element. At least one of the plug element or the side wall of the recess are provided with a protrusion for fixing the plug element in a given position relative to the housing part by a force-fit engagement. Furthermore, a coupling assembly is proposed, the coupling assembly comprising the plug element and the housing part being mechanically coupled to each other.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: June 27, 2017
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventor: Michael Harms
  • Mounting arrangement and coupling assembly for a drug-delivery device
    Patent number: 9687609
    Abstract: A mounting arrangement for a drug-delivery device is proposed, the mounting arrangement comprising: a plug element with a longitudinal axis (L) and a housing part having a recess with a side wall which is adapted to receive the plug element. At least one of the plug element or the side wall of the recess are provided with a protrusion for fixing the plug element in a given position relative to the housing part by a force-fit engagement. Furthermore, a coupling assembly is proposed, the coupling assembly comprising the plug element and the housing part being mechanically coupled to each other.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: June 27, 2017
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventor: Michael Harms
  • Resetting mechanism for a drug delivery device
    Patent number: 9687613
    Abstract: A resettable dose setting mechanism for a drug delivery device comprising a driver for driving a spindle of the drug delivery device is provided. Said driver comprises a first component and a second component rotationally coupled to said first component. During resetting of said drug delivery device, said first component is rotationally decoupled from said second component.
    Type: Grant
    Filed: April 24, 2012
    Date of Patent: June 27, 2017
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: David Plumptre, Christopher Jones
  • Assembly for a drug delivery device
    Patent number: 9687614
    Abstract: An assembly for a drug delivery device is provided the assembly comprising a cartridge adapted and arranged to contain at least one dose of a drug, a bung being slidably arranged within the cartridge, a housing comprising a distal end and a proximal end, and a piston rod adapted and arranged for moving the bung in the distal direction with respect to the housing for dispensing a dose of the drug. The assembly further comprises a drive member and arranged for transferring movement to the piston rod for dispensing the dose, and an engagement member configured to mechanically cooperate with the piston rod and with the housing.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: June 27, 2017
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventor: Michael Harms
  • Pharmaceutical compositions containing toxoids A and B
    Patent number: 9687541
    Abstract: This invention relates to compositions including Clostridium difficile toxins and/or toxoids and corresponding methods. The compositions of the invention include one or more excipients that increase stability and/or decrease aggregation of the toxins.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: June 27, 2017
    Assignee: Sanofi Pastuer Biologies, LLC
    Inventors: C. Russell Middaugh, Richard Fahrner, Peter Ciarametaro
  • Macrocyclic urea and sulfamide derivatives as inhibitors of TAFIa
    Patent number: 9688645
    Abstract: The invention relates to compounds of the formula (I) which are inhibitors of activated thrombin-activable fibrinolysis inhibitor. The compounds of the formula I are suitable for producing medicaments for prophylaxis, secondary prevention and treatment of one or more disorders associated with thromboses, embolisms, hypercoagulability or fibrotic changes.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: June 27, 2017
    Assignee: SANOFI
    Inventors: Christopher Kallus, Mark Broenstrup, Andreas Evers, Anja Globisch, Herman Schreuder, Michael Wagner
  • Pharmaceutical compositions comprising human antibodies to PCSK9
    Patent number: 9682013
    Abstract: The present invention relates to Pharmaceutical compositions comprising an antibody specifically binding to human proprotein convertase subtilisin/kexin type 9 (PCSK9), to methods for treating diseases or conditions in which proprotein convertase subtilisin/kexin type 9 (PCSK9) expression or activity causes an impact by administration of PCSK9-specific antibodies or antigen-binding fragments thereof and preferably by additional administration of an inhibitor of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase). The present invention further relates to PCSK9-specific antibodies or antigen-binding fragments thereof for use in the treatment of diseases or conditions in which PCSK9 expression or activity causes an impact.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: June 20, 2017
    Assignee: SANOFI BIOTECHNOLOGY
    Inventors: Corinne Hanotin, Laurence Bessac, Umesh Chaudhari
  • Drive mechanism for a drug delivery device and drug delivery device
    Patent number: 9675760
    Abstract: The drive mechanism for a drug delivery device comprises a piston rod, which is displaced in a distal direction for a delivery of a dose and in a proximal direction for a reset, and a rotatable drive member, which is threadedly engaged with the piston rod and rotates during the delivery of the dose. A biasing member is provided, which is loaded by the rotation of the drive member during the delivery of the dose and tends to rotate the piston rod with respect to the drive member in such a way that the piston rod is screwed into the drive member and is thereby advanced in the proximal direction. The drug delivery device is provided with such a drive mechanism.
    Type: Grant
    Filed: May 28, 2013
    Date of Patent: June 13, 2017
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Stephen David Butler, Mark Philip Horlock
  • Medicament injection device
    Patent number: D789519
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: June 13, 2017
    Assignee: SANOFI
    Inventors: Jochen Ratjen, Katja Wessel
  • Autoinjector cap
    Patent number: D789528
    Type: Grant
    Filed: March 11, 2015
    Date of Patent: June 13, 2017
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Tobias Wohlfahrt, Christian Rogge