Abstract: Single tube preparations include a panel of differently labeled serologically relevant blood cells for blood serology, and methods for preparing the present single tube preparations. Use of the present single tube preparations for blood serology and to methods for serologically characterizing an individual in need of a blood transfusion, a blood donor or for preventive serologically characterizing an individual, such as a pregnant woman. The single tube preparations and methods are especially suited for automation and high-through put blood serology.

Abstract: In one aspect, the disclosure relates to major histocompatibility complex (MHC) molecules comprising a ligand in the peptide binding groove of the MHC molecule, whereby the ligand comprises an azobenzene (Abc), and at least two amino acid residues separated by the azo-group of the Abc, and wherein the amino acid residues are positioned to interact with the peptide binding groove of the MHC molecule. The disclosure also relates, among others, to means and methods for producing and using such MHC molecules, and the ligands therefor.