Abstract: An object t of the present invention is to proroaide crystal of a cyclic phosphonic acid sodium salt (2ccPA) with high purity and excellent storage stability and a method for producing the crystal.

Abstract: This invention provides a therapeutic agent for arthrosis exerting inhibitory effects on articular cartilage destruction and high therapeutic effects on arthrosis. The invention provides a therapeutic agent for arthrosis which comprises, as an active ingredient, cyclic phosphatidic acid or carbacyclic phosphatidic acid.

Abstract: This invention provides a therapeutic agent for arthrosis exerting inhibitory effects on articular cartilage destruction and high therapeutic effects on arthrosis. The invention provides a therapeutic agent for arthrosis which comprises, as an active ingredient, cyclic phosphatidic acid or carbacyclic phosphatidic acid.

Abstract: A pharmacological composition for percutaneous administration to a human patient comprises a pharmacologically effective amount of eperisone, a salt thereof, tolperisone or a salt thereof, a water-swellable crosslinked polyvinylpyrrolidone and a base carrier, and exhibits improved percutaneous absorption.

Abstract: (A) a diacylated dopamine derivative represented by the formula (I): ##STR1## wherein R.sup.1 represents an alkyl group having 3 to 7 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, substituted or unsubstituted phenyl group or a substituted or unsubstituted nitrogen-containing heterocyclic group; and R.sup.2 represents a hydrogen atom or a lower alkyl group; or a salt thereof; and(B) one or more compounds selected from lactic acid esters, fatty acid monoglycerides and higher alcohols; optionally together with(C) an unsaturated fatty acid monohydric alcohol ester. This preparation has a sustained effect, a high skin permeability and a low skin irritativeness.

Abstract: A pharmaceutical preparation for the percutaneous administration comprises eperisone or tolperisone, including salts thereof, and a monoglyceride of an aliphatic acid having 8 to 12 carbon atoms or/and an ester of lactic acid with an aliphatic alcohol having 12 to 18 carbon atoms. It is improved in the percutaneous absorption.

Abstract: A pharmaceutical preparation for the percutaneous administration comprises eperisone or tolperisone, including salts thereof, and a monoglyceride of an aliphatic acid having 8 to 12 carbon atoms or/and an ester of lactic acid with an aliphatic alcohol having 12 to 18 carbon atoms. It is improved in the percutaneous absorption.

Abstract: A pharmaceutical composition comprises (a) a pharmacologically effective amount of bunazosin or a pharmacologically acceptable salt thereof and (b) a monoglyceride of a fatty acid having 8 to 12 carbon atoms and/or a lactic acid ester of an aliphatic alcohol having 12 to 18 carbon atoms and is improved in percutaneous administration.

Abstract: A process for improving the qualities of paper which comprises making co-exist (a) a water-soluble polymer containing hydrazide group or its adduct with a water-soluble inorganic salt of an alkaline earth metal and (b) a heavy metal ion capable of chelating with the polymer or its adduct in a pulp slurry in paper making. The use of the water-soluble polymer or its adduct in combination with the heavy metal ion improves markedly the paper strength, the retention of sizing agents and the retention of fillers at a pH value around neutrality.

Abstract: A bonding composition for incombustible fibrous materials comprising (a) a water-soluble polymer containing hydrazide groups or its adduct with a water-soluble alkaline earth metal salt of an inorganic acid and (b) a heavy metal ion capable of forming chelate with the water-soluble polymer or its adduct. The bonding composition is employed as bonding agents to prepare incombustible sheet materials from incombustible fibrous materials by adding the components (a) and (b) to an aqueous dispersion of the fibrous materials and forming sheets or by forming wet or dry sheets containing the component (b) and then making the component (a) contain in the sheets. The bonding composition has excellent bonding effect and the polymer itself becomes incombustible, so incombustible sheet materials having excellent strength can be economically obtained.

Abstract: At least one cylinder driven at a constant speed is contained in a casing and a dial plate mounted on the casing is provided with a window extending in the direction of the cylinder. The upper edge of the window is marked with digits. The outer periphery of the cylinder is divided into two sections by a line inclined a definite angle with respect to the axis of the cylinder, and the two areas are coloured by different colours. The inclined line cooperates with the digits to display time. When two or three cylinders are used it is possible to display hours, minutes and seconds.