Abstract: The invention provides a method of treatment of a human or non-human subject to combat sub-dermal soft tissue pain therein, said method comprising administering to a subject in need thereof an effective amount of a physiologically tolerable strontium compound.

Abstract: The invention provides a method of treatment of a human or non-human subject to combat sub-dermal soft tissue pain therein, said method comprising administering to a subject in need thereof an effective amount of a physiologically tolerable strontium compound.

Abstract: An applicator adapted for applying a liquid from a source of liquid to the skin of an individual subject. The applicator includes a housing delimiting a chamber, and a roller rotatably mounted in the housing with an adhesion side extending into the chamber and a transfer side extending out of the chamber. A cylinder is attached to the housing, at least one outlet and one through hole which are formed in the wall of the cylinder, is connecting the cylinder to the source of liquid and to the chamber, respectively, with the through holes axially and angularly displaced in relation to each other. A slider is arranged for sliding between first and second positions in the cylinder, a recess is formed in the slider, and the recess communicates with the source of liquid in the first position of the slider via the at least one first through hole and with the chamber in the second position of the slider via the at least one second through hole.

Abstract: The invention provides a method of treatment of a human or non-human subject to combat sub-dermal soft tissue pain therein, said method comprising administering to a subject in need thereof an effective amount of a physiologically tolerable strontium compound.