Patents Assigned to Sanwa Kagaku Kenkyusho Co., Ltd.
  • Patent number: 5196303
    Abstract: A cloned single-strand DNA encoding amino acid sequence for a eukaryotic transcription factor S-II is disclosed together with, a cloned double-strand DNA consisting of the single-strand DNA and its complementary single-strand DNA, a DNA fragment of the single- or double-strand DNA, a process for the preparation thereof, a plasmid, in which the double-strand DNA or its fragment is inserted, and a diagnosis of viral diseases and cancers.
    Type: Grant
    Filed: April 11, 1991
    Date of Patent: March 23, 1993
    Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.
    Inventor: Shunji Natori
  • Patent number: 5180739
    Abstract: A pharmaceutical composition is used to treat and prevent a diabetes-dependent type of autoimmune diseases, said pharmaceutical composition comprising a therapeutically effective amount of 3-oxygermylpropionic acid represented by the following formula:[(O.sub.1/2).sub.3 GeCH.sub.2 CH.sub.2 CO.sub.2 H].sub.nwherein n stands for an integer of 1 or more, optionally with an activating carrier.
    Type: Grant
    Filed: February 23, 1991
    Date of Patent: January 19, 1993
    Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.
    Inventors: Kiichi Sawai, Masayasu Kurono, Takahiko Mitani, Masanori Nagabuchi, Keizo Anzai
  • Patent number: 5177102
    Abstract: There are given disclosures on a polyisoprene compound of the formula ##STR1## wherein Y is S, O, NH or ##STR2## .sub.l is an integer of 2-10, Z is a group of ##STR3## R.sup.1 and R.sup.2 are same or different and each means a hydrogen atom or an alkyl group having C.sub.1-4, m is an integer of 0 or 1, and .sub.n is an integer of 0, 1 or 2,a salt thereof, a process for the preparation of same, and use thereof.
    Type: Grant
    Filed: May 3, 1991
    Date of Patent: January 5, 1993
    Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.
    Inventors: Masayasu Kurono, Yasuaki Kondo, Takuji Yamaguchi, Ryoichi Unno, Hiromoto Kimura, Noboru Kuboyama, Takashi Ito, Mitsuru Oka, Akira Tashita, Kazumasa Nakano, Kiichi Sawai
  • Patent number: 5171865
    Abstract: A process for the preparation of optically active 4-oxo-1-benzopyran-2-carboxylic acid derivatives of the formula ##STR1## wherein X and Y are hydrogen atom, halogen atom or alkyl group, and R.sub.1 is hydrogen atom or alkyl group,intermediates thereof, as well as a process for the preparation of the intermediates.
    Type: Grant
    Filed: March 5, 1991
    Date of Patent: December 15, 1992
    Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.
    Inventors: Masayasu Kurono, Yasuaki Kondo, Kenji Miura, Toshinao Usui, Ryoichi Unno, Takuji Kakigami, Kiichi Sawai
  • Patent number: 5166388
    Abstract: A stabilized composition of phytic acid is obtained by the steps of:heating and drying rice bran de-fatted by pressing;adding acidic water of pH 3 to 5 to the dried rice bran, stirring the solution and completing the stirring before the pH of the solution reaches 5.7; andheating the thus obtained liquid extract to solidify protein components, followed by the removal of the solid matters by filtration. This composition is advantageously used for removing uraroma and body odor.
    Type: Grant
    Filed: July 6, 1990
    Date of Patent: November 24, 1992
    Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.
    Inventors: Kiichi Sawai, Masayasu Kurono, Hiromoto Asai, Takahiko Mitani, Naohisa Ninomiya
  • Patent number: 5164391
    Abstract: The invention relates to a hydantoin derivative, salt thereof, process for the preparation thereof, and medicine containing the derivative. The derivative is represented by the formula ##STR1## wherein M is --CONH--NHR.sup.1 group, --CONH--OR.sup.2 group, ##STR2## in which R.sup.1 is hydrogen atom, an alkyl group, an alkenyl group, a phenyl radical, a substituted phenyl group, a naphthyl radical, a substituted naphthyl group, a pyridyl radical, a furyl radical or a thienyl radical, R.sup.2 is a hydrogen atom, an alkyl group, a phenyl radical or a substituted phenyl group, R.sup.3 and R.sup.4 are the same or different independently, each being a phenyl radical, or an aralkyl group, or R.sup.3 may form a substituted or non-substituted C.sub.5-6 saturated heterocyclic ring together with R.sup.4 and a possible nitrogen or oxygen atom, R.sup.5 forms a substituted or non-substituted saturated heterocyclic ring together with R.sup.6 and a possible nitrogen or oxygen atom, R.sup.
    Type: Grant
    Filed: September 13, 1990
    Date of Patent: November 17, 1992
    Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.
    Inventors: Masayasu Kurono, Ryoichi Unno, Hiromoto Kimura, Noboru Tomiya, Kiichi Sawai, Kenji Miura, Toshinao Usui, Yasuaki Kondo, Yukiya Tanaka, Shigeyoshi Nakamura, Tsunemasa Suzuki, Motohide Hayashi
  • Patent number: 5155125
    Abstract: A therapeutic preparation for ulcers contains as a primary ingredient a compound having an aldose reductase inhibitory activity and can accelerate dermal metabolism. That compound may be d-6-fluoro-2,3-dihydro-2',5'-dioxo-spiro [4H-1-benzopyran-4,4'-imidazolidine]-2-carboxyamide, d-2-chloromethyl-6-fluoro-2,3-dihydro-spiro [4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione and d-2-bromomethyl-6-fluoro-2,3-dihydro-spiro [4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione.
    Type: Grant
    Filed: October 22, 1990
    Date of Patent: October 13, 1992
    Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.
    Inventors: Kiichi Sawai, Masayasu Kurono, Kazumasa Nakano, Makoto Sato, Noboru Kuboyama, Takashi Ito, Yoshiya Kondo
  • Patent number: 5118789
    Abstract: An antibacterial polypeptide is disclosed, which is immunologically produced by Sarcophaga peregrina, when the insect is injured in its body wall. The polypeptide has a molecular weight of about 7000.
    Type: Grant
    Filed: June 5, 1991
    Date of Patent: June 2, 1992
    Assignee: Sanwa Kagaku Kenkyusho Co. Ltd.
    Inventor: Shunji Natori
  • Patent number: 5118503
    Abstract: Composition obtained from a rice bran, which comprises a filtrate of lactic fermented and aged material of the rice bran, the filtrate being an odorless pale yellow solution, having a salty taste, and solubility with water and alcohols, or a powderized substance of the filtrate, a process for the preparation of the composition, and use of the composition as a deodorant.
    Type: Grant
    Filed: June 1, 1989
    Date of Patent: June 2, 1992
    Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.
    Inventors: Kiichi Sawai, Masayasu Kurono, Hiromoto Asai, Takahiko Mitani, Naohisa Ninomiya, Eiji Furukawa
  • Patent number: 5110945
    Abstract: There are described 1-azoniabicyclo[3.3.0]oct-1(5)-ene salt derivatives inclusive of 1-azonia-4,6-dimethylbicyclo[3.3.0]oct-1(5)-ene perchlorate, and a process for the preparation of the same. The derivatives can be prepared by heating dicyclopropylmethanimine salt derivative in a solvent, in the presence or absence of an ammonium salt. Each of the derivatives is employed as an intermediate for preparing various medicines and agricultural chemicals.
    Type: Grant
    Filed: October 15, 1991
    Date of Patent: May 5, 1992
    Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.
    Inventors: Masayasu Kurono, Yasuaki Kondo, Yukiharu Matsumoto, Mitsuru Oka, Kiichi Sawai
  • Patent number: 5106735
    Abstract: A cloned single-strand DNA comprising nucleotide sequence which encodes an antibacterial polypeptide precursor, a cloned double-strand DNA consisting of the single-strand DNA and its complementary single-strand DNA, a DNA fragment of the single- or double-strand DNA, a process for the preparation thereof, and a plasmid, in which the double-strand DNA or its fragment is inserted.
    Type: Grant
    Filed: July 25, 1988
    Date of Patent: April 21, 1992
    Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.
    Inventors: Shunji Natori, Haruo Takahashi, Kenichi Tanaka, Takahiko Mitani, Masayasu Kurono, Kiichi Sawai
  • Patent number: 5089265
    Abstract: A stabilized phytic acid composition is provided, which comprises phytic acid or its salt and at least one stabilizer selected from the group consisting of a product obtained by the lactic fermentation and ripening of rice bran, a water-soluble polymer capable of forming a film and an additive capable of absorbing water.
    Type: Grant
    Filed: October 24, 1989
    Date of Patent: February 18, 1992
    Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.
    Inventors: Kiichi Sawai, Masayasu Kurono, Hiromoto Asai, Takahiko Mitani, Naohisa Ninomiya
  • Patent number: 5059594
    Abstract: A novel composition contains phytic acid and ferric ions as main ingredients and carboxylic acid ions as a dissolution accelerator, and may further include at least one or more or two additives selected from the group consisting of a carboxylic acid or its salt, saccharides, an amino acid or its salt and an organic phosphoric acid or its salt.
    Type: Grant
    Filed: March 22, 1990
    Date of Patent: October 22, 1991
    Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.
    Inventors: Kiichi Sawai, Masayasu Kurono, Hiromoto Asai, Takahiko Mitani, Naohisa Ninomiya, Tomoo Suzuki
  • Patent number: 5055392
    Abstract: A cloned single-strand DNA encoding amino acid sequence for a eukaryotic transcription factor S-11 is disclosed together with, a cloned double-strand DNA consisting of the single-strand DNA and its complementary single-strand DNA, a DNA fragment of the single- or double-strand DNA, a process for the preparation thereof, a plasmid, in which the double-strand DNA or its fragment is inserted, and a diagnosis of viral diseases and cancers.
    Type: Grant
    Filed: September 19, 1988
    Date of Patent: October 8, 1991
    Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.
    Inventor: Shunji Natori
  • Patent number: 5041429
    Abstract: Phytic acid or at least one of its salts is used as an effective component for cell activators in a hypoxic state, circulatory ameliorators, dementia remedies and edible compositions.
    Type: Grant
    Filed: May 22, 1989
    Date of Patent: August 20, 1991
    Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.
    Inventors: Kiichi Sawai, Masayasu Kurono, Hiromoto Asai, Takahiko Mitani, Motohide Hayashi, Tunematu Suzuki, Naohisa Ninomiya
  • Patent number: 5017486
    Abstract: A cloned single-strand DNA comprising nucleotide sequence which encodes an antibacterial polypeptide precursor, a cloned double-strand DNA consisting of the single-strand DNA and its complementary single-strand DNA, a DNA fragment of the single- or double-strand DNA, a process for the preparation thereof, and a plasmid, in which the double-strand DNA or its fragment is inserted are disclosed.
    Type: Grant
    Filed: July 25, 1988
    Date of Patent: May 21, 1991
    Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.
    Inventors: Kiichi Sawai, Shunji Natori, Haruo Takahashi, Kenichi Tanaka, Takahiko Mitani, Masayasu Kurono
  • Patent number: 5008416
    Abstract: An organogermanium compound of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are hydrogen atom, alkyl, substituted alkyl, phenyl or substituted phenyl, and R.sub.5 is a radical of ##STR2## n is an integer of 2 or more, and R.sub.6 and R.sub.7 are hydrogen atom, alkyl, substituted alkyl, phenyl or substituted phenyl,a salt of the compound, a processs for the preparation of the compound as well as a use of the compound as an affective ingredient for pharmaceutical preparations.
    Type: Grant
    Filed: June 19, 1990
    Date of Patent: April 16, 1991
    Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.
    Inventors: Masayasu Kurono, Yasuaki Kondo, Takahiko Mitani, Yutaka Baba, Kiichi Sawai
  • Patent number: 5008371
    Abstract: A biologically active polypeptide, method of obtaining same and use thereof are disclosed. The polypeptide is obtained through steps of cultivating a cell line established from Sarcophaga peregrina embryo to produce the same in a culture medium, as product of the cell line, isolating and purifying the same. The polypeptide shows an anti-virus activity.
    Type: Grant
    Filed: January 22, 1988
    Date of Patent: April 16, 1991
    Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.
    Inventor: Shunji Natori
  • Patent number: 4985356
    Abstract: A cloned single-strand DNA comprising nucleotide sequence which encodes human motilin precursor, a cloned double-strand DNA consisting of the single-strand DNA and its complementary single-strand DNA, a fragment of the single- or double-strand DNA, a plasmid, in which the double-strand DNA or its fragment is integrated, as well as a process for the preparation of the single- or double-strand DNA.
    Type: Grant
    Filed: May 6, 1988
    Date of Patent: January 15, 1991
    Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.
    Inventors: Kiichi Sawai, Jun Takeda, Yutaka Seino, Hiroo Imura, Kenichi Tanaka, Haruo Takahashi, Takahiko Mitani, Masayasu Kurono
  • Patent number: 4985569
    Abstract: 7a-Nitromethyl-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine of the formula ##STR1## and salts thereof, as well as processes for the preparation of the compound and 7a-aminomethyl-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine and salts thereof.
    Type: Grant
    Filed: May 12, 1989
    Date of Patent: January 15, 1991
    Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.
    Inventors: Masayasu Kurono, Yasuaki Kondo, Ryoichi Unno, Yukiharu Matsumoto, Hiromoto Kimura, Mitsuru Oka, Kiichi Sawai