Patents Assigned to Sanwa Kagaku Kenkyusho Co.
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Patent number: 5521157Abstract: The modified polypeptide compound of the present invention is represented by the following general formula ((SEQ ID NO: 2)-X):His-Ser-Asp-Ala-Val-Phe-Thr-Gly-Asn-Tyr-Thr-Lys-Leu-Arg-Lys-Gln-Leu-Ala-Ala -Lys-Lys-Tyr-Leu-R.sup.1 -Lys-Ala-Leu-R.sup.2 -Hse-Xwherein R.sup.1 represents an Asn, Lys or Gln residue, R.sup.2 represents a Lys or Arg residue, Hse represents a homoserine residue, and X represents NHR.sup.3 or NR.sup.4 R.sup.5, wherein R.sup.3 represents a hydrocarbon residue having 18 or less carbon atoms or a polyalkylamine having 2 or more amino groups in its molecule, or R.sup.4 and R.sup.5 represent hydrocarbon residues, provided that the total carbon number of R.sup.4 and R.sup.5 is 18 or less. This modified polypeptide compound has a strong activity as a smooth muscle relaxant, and has excellent stability and prolonged duration of action. These characteristics make it suitable as an active ingredient in a drug for preventing and treating bronchial asthma and impotence.Type: GrantFiled: December 20, 1994Date of Patent: May 28, 1996Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Hitoshi Noda, Hidehumi Yamakawa, Shigeaki Yoshina, Tsutomu Ishida, Noboru Tomiya
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Patent number: 5502209Abstract: There are disclosed a benzopyrancarboxamide derivative of the formula ##STR1## wherein R.sup.1 is hydrogen atom or a lower alkyl group; R.sup.2 is hydrogen atom, a lower alkyl group, halogen atom, an amino radical or an acylamino group; R.sup.3 is hydrogen atom, a lower alkyl group, a lower alkoxy group or halogen atom; dotted line is a possible double bond; and n is an integer of 1-5,and a pharmacologically acceptable salt of the compound, a process for the preparation of the compound and salt as well as use thereof.Type: GrantFiled: June 13, 1995Date of Patent: March 26, 1996Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Yutaka Baba, Toshinao Usui, Takuji Kakigami, Yoshiro Ozeki, Katsura Tsukamoto, Nobuyuki Asaeda, Nobuyuki Itoh
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Patent number: 5474913Abstract: Process for the preparation of motilin-like polypeptide, a recombinant DNA therefor, and a plasmid, in which the recombinant DNA is inserted.Type: GrantFiled: January 26, 1993Date of Patent: December 12, 1995Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Masayasu Kurono, Takahiko Mitani, Haruo Takahashi, Kenichi Tanaka, Katsuya Fujimura, Kiichi Sawai
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Patent number: 5474908Abstract: A method of enzymatically measuring hydrogen peroxide by developing a color with use of 3-methyl-2-benzothiazolinoehydrazone as a coupler and in combination with an oxidative color developing reagent with peroxidase, and a reagent therefor is described. Catalase is added to the 3-methyl-2-benzothiazolinonehydrazone reagent as a stabilizer and the reaction is carried out in the presence of ethylenediaminetetraacetic acid or an analogue thereof. The color developing reaction may be carried out in neutral or weak alkali conditions. A reagent is described which comprises a buffer, 3-methyl-2-benzothiazolinohydrazone, and catalase.Type: GrantFiled: November 25, 1991Date of Patent: December 12, 1995Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Masayasu Kurono, Shizuo Uno, Osamu Takehiro, Kiichi Sawai
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Patent number: 5468728Abstract: A readily absorbable type of motilin preparation containing a motilin-like active substance and a surface active agent is provided, in which the motilin-like active substance is mainly L-leucine-13-motilin-homoserine, and the surface active agent is selected from the group consisting of a bile salt, saponin and a polyethylene glycol higher-alcohol ether for nasal administration purposes and is a peptide lytic enzyme inhibitor for oral administration purposes.Type: GrantFiled: September 8, 1993Date of Patent: November 21, 1995Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Kiichi Sawai, Masayasu Kurono, Takahiko Mitani, Makoto Sato, Hiroyuki Oowaki, Bunkichi Kato, Haruo Takahashi
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Patent number: 5464818Abstract: There are described a novel protein derived from Clostridium perfringens FERM BP-4584 method of obtaining the same and use thereof as an effective ingredient for treating wounds and ulcers. The protein has a molecular weight of 420,000.+-.40,000 by a GPC, isoelectric point of 4.8, and consists of a single subunit having a molecular weight of 130,000.+-.20,000 by a SDS-polyacrylamide gel electrophoresis, and shows cell growth-stimulating activity as well as macrophage chemotactic action. The protein can be extracted and separated by conventional techniques for obtaining a protein from general microorganisms, by taking an inhibition of decomposition into consideration, since the protein is not so stable.Type: GrantFiled: December 29, 1994Date of Patent: November 7, 1995Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Tadashi Yamaguchi, Hiroshi Uesaka, Kazuo Watanabe, Juichi Awaya
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Patent number: 5447946Abstract: Hydantoin derivatives and salts thereof, intermediates therefor, process for the preparation thereof, and medicines containing the derivative, wherein said derivatives have the formula ##STR1## wherein one of V and W is hydrogen and the other is a halogenomethyl group, 1H-tetrazol-5-yl radical, --COOR group,in which R is hydrogen atom, an alkyl group, --(CH.sub.2 CH.sub.2 O)nCH.sub.3 group (n is an integer of 1 to 113) or substituted phenyl, ##STR2## in which R.sub.1 and R.sub.2 are same or different independently, each is hydrogen atom, an alkyl group, substituted phenyl or --(CH.sub.2 CH.sub.2 O)nCH.sub.3 group (n has the meaning as referred to) or R.sub.1 may form a heterocyclic ring together with R.sub.2 and nitogen or oxygen atom,--CH.sub.2 OH.sub.3 group or ##STR3## group, in which R.sub.3 and R.sub.Type: GrantFiled: September 23, 1994Date of Patent: September 5, 1995Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Masayasu Kurono, Yasuaki Kondo, Takuji Yamaguchi, Kenji Miura, Toshinao Usui, Naofumi Terada, Kyoichi Asano, Kuniharu Mizuno, Akira Matsubara, Noriaki Kato, Kiichi Sawai, Ryoichi Unno, Hiroshi Ozawa, Masato Fukushima
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Patent number: 5442077Abstract: There are disclosed a benzo[b]furancarboxamide derivative of the formula ##STR1## wherein R.sup.a, R.sup.b, R.sup.c and R.sup.d are a hydrogen atom or lower alkyl group, respectively; R.sup.e is a hydrogen atom, amino radical, lower alkylamino group or acylamino group; X is a hydrogen atom or halogen atom; and n is an integer of 1-5,and including racemic compounds and stereo-isomers thereof, a salt of the compounds, a process for the preparation of the compounds and salts as well as use thereof for improving hypermotility.Type: GrantFiled: August 4, 1994Date of Patent: August 15, 1995Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Yutaka Baba, Toshinao Usui, Noriyuki Iwata, Takuji Kakigami, Yoshiro Ozeki, Katsura Tsukamoto, Nobuyuki Ito
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Patent number: 5434082Abstract: Early diagnosis of mastitis or garget is carried out by measuring the concentration of 3-hydroxybutyric acid in milk. Used to this end is a reagent reacting with 3-hydroxybutyric acid to show a color at a concentration of 100 .mu.mol/l or higher.Type: GrantFiled: January 7, 1993Date of Patent: July 18, 1995Assignee: Sanwa Kagaku Kenkyusho Co., LtdInventors: Hideo Yamamoto, Eiji Furukawa, Hiromoto Asai, Masayasu Kurono, Kiichi Sawai
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Patent number: 5432261Abstract: A pharmaceutical composition for stimulating peristaltic contraction in the intestinal canal which contains a pharmaceutically acceptable carrier or excipient and an effective amount of a polypeptide, or a salt thereof, having a pharmacological activity similar to motilin. The polypeptide has the formula B.sub.1 -Z.sub.1 -A.sub.1 -Z.sub.2 -B.sub.2 -Thr-B.sub.3 -A.sub.2 -Glu-Z.sub.3 -C-Arg-X'-Gln-Glu-Lys-Glu-Arg-D-Lys-Gly-E-Y, with Z.sub.1,Z.sub.2 and Z.sub.3 each being an amino acid residue having a hydrophobic side-chain, A.sub.1 and A.sub.2 each being an amino acid residue such as Pro, Gly, Asn and Ser, B.sub.1, B.sub.2 and B.sub.Type: GrantFiled: September 11, 1992Date of Patent: July 11, 1995Assignee: Sanwa Kagaku Kenkyusho Co. Ltd.Inventors: Masayasu Kurono, Takahiko Mitani, Haruo Takahashi, Kenichi Tanaka, Katsuya Fujimura, Yuji Hayashi, Yohei Kobayashi, Kiichi Sawai
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Patent number: 5376637Abstract: There is disclosed a pharmaceutical preparation which contains vasoactive intestinal polypeptide (VIP), its analogue or a salt thereof, and a surfactant. The preparation shall contains further a peptidase inhibitor. The composition is administrated to suppress allergies, reduce blood pressure, increase secretion of tear, cure asthma and impotence and others.Type: GrantFiled: April 16, 1992Date of Patent: December 27, 1994Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Kiichi Sawai, Masayasu Kurono, Takahiko Mitani, Makoto Sato, Haruo Takahashi, Hiroyuki Ohwaki
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Patent number: 5364533Abstract: A process for separating and recovering serum and plasma components from a whole blood sample including passing a whole blood sample through a separating filter formed of a blood cell separating layer composed mainly of fibers impregnated with a coating agent. A device includes a blood collector having a needle at one end and a blood suction means at the other end, and a separating filter including a blood cell separating layer, the filter being provided in the intermediate zone of the blood collector, whereby a whole blood sample sucked through the needle by depressurizing the blood suction means is passed through the separating filter.Type: GrantFiled: July 14, 1992Date of Patent: November 15, 1994Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Shinji Ogura, Hiroshi Okada, Shizuo Uno, Takashi Iida, Hiromoto Asai, Masayasu Kurono, Kiichi Sawai
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Patent number: 5356880Abstract: The invention provides a novel glycoside which contains as the aglycon a 4-(substituted phenyl)piperazine-1-yl derivative of glycyrrhetinic acid and 11-deoxo-glycyrrhetinic acid or their derivative as well as a composition for the treatment of virus infection, which contains these compounds as a main active component.Type: GrantFiled: May 28, 1992Date of Patent: October 18, 1994Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Masayasu Kurono, Yoshiro Ishiwata, Syoji Yokochi, Kyoichi Asano, Takahiko Mitani, Takuji Kakigami, Noriyuki Iwata, Kougaku Isogawa, Yutaka Baba, Hiroyuki Ohwaki, Kiichi Sawai, Hiromoto Kimura, Masato Fukushima, Ryoichi Unno, Tamaki Ohtuka
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Patent number: 5340806Abstract: A composition comprising an organogermanium compound represented by the formula ##STR1## wherein n is an integer of 1 or more, R is hydrogen, alkyl, --COOH, --COOR', phenyl, ##STR2## and R' is a lower alkyl and a high molecular carrier, as well as an immunity adjusting agent comprising the composition. The treatment of hepatitis with compositions containing this germanium derivative.Type: GrantFiled: January 7, 1993Date of Patent: August 23, 1994Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Kiichi Sawai, Masayasu Kurono, Juichi Awaya, Akio Kojima, Hideaki Ninomiya, Yoshiro Ishiwata, Masahiro Nakajima
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Patent number: 5336688Abstract: A composition comprising an organogermanium compound represented by the formula ##STR1## wherein n is an integer of 1 or more, R is hydrogen, alkyl, --COOH, --COOR', phenyl, ##STR2## and R' is a lower alkyl and a high molecular carrier, as well as an immunity adjusting agent comprising the composition.Type: GrantFiled: January 25, 1993Date of Patent: August 9, 1994Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Kiichi Sawai, Masayasu Kurono, Juichi Awaya, Akio Kojima, Hideako Ninomiya, Yoshiro Ishiwata, Masahiro Nakajima
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Patent number: 5308836Abstract: There is disclosed a pharmaceutical composition of stabilized [Leu.sup.13 ]-motilin-Hse. The composition comprises at least one of organic acids and salts thereof, as a first stabilizer, and pH thereof is adjusted in a range of 5.5-8.0. The composition may contain at least one of substances selected from saccharides, amino acids, proteins and salts thereof, as a second stabilizer. Conversion of [Leu.sup.13 ]-motilin-Hse into [Leu.sup.13 ]-motilin-Hse-lactone is suppressed by increasing pH value and deamidization in asparagine residue at 19-position is suppressed by the presence of the organic acid or salt thereof.Type: GrantFiled: September 7, 1993Date of Patent: May 3, 1994Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Kiichi Sawai, Masayasu Kurono, Yasuaki Kondo, Makoto Sato, Toshiyuki Kouzaki
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Patent number: 5290679Abstract: Even when the specimen contains human granulocyte elastase in the form of a mixture of free elastase with an elastase-inhibitor complex or complexes, the present invention enables the total quantity of elastase in that specimen to be precisely detected. The inhibitor is added to free elastase to convert it into an elastase-inhibitor complex, whereby the quantity of elastase can be measured by immunoassay as the total amount including the previously existing elastase-inhibitor complex. It is possible to precisely measure the total amount of elastase in mucus collected from the cervical canal of a pregnant woman, sputum or a rinsed solution of bronchovesicular lavage in which free elastase is mixed with an elastase-inhibitor complex.Type: GrantFiled: June 15, 1992Date of Patent: March 1, 1994Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Toshihiko Terao, Naohiro Kanayama, Akihiro Morioka, Yoshika Yasuda, Masami Kamiya, Juichi Awaya, Masayasu Kurono, Kiichi Sawai
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Patent number: 5279835Abstract: A 3-oxygermylpropionic acid preparation is provided, which activates the action of 3-oxygermylpropionic acid having the general formula:[(O.sub.1/2).sub.3 GeCH.sub.2 CH.sub.2 COOH]n wherein n=an integer of at least 1 and is readily solubilized and disintegrated in vivo. The present preparation is manufactured by compression-molding at high pressure a composition comprising 3-oxygermylpropionic acid and two or more low-molecular substance of high solubility in water. The low-molecular substances are selected from the group consisting of white sugar, sorbitol, fructose, sucrose, glucose, lactose, mannitol and sodium chloride.Type: GrantFiled: June 30, 1992Date of Patent: January 18, 1994Assignee: Sanwa Kagaku Kenkyusho Co. Ltd.Inventors: Kiichi Sawai, Masayasu Kurono, Takahiko Mitani, Yasuaki Kondo, Makoto Sato, Yoshiro Ishiwata, Syoji Yokochi, Toshiyuki Kouzaki
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Patent number: 5260064Abstract: A percutaneous-administration-type pharmaceutical preparation of nitroglycerin is provided. The preparation comprises a backing that is impervious to medicines, and a pressure-sensitive adhesive layer that is placed on one surface of said backing, wherein said pressure-sensitive adhesive layer contains an alkyl (meth)acrylate (co)polymer in the concentration of 35-85% by weight, nitroglycerin in the concentration of 10-30% by weight, and a silicic acid anhydride in the concentration of 5-20% by weight, said (co)polymer contains as major (co)polymer components alkyl (meth)acrylates with alkyl groups having 6 or more carbon atoms, which alkyl (meth)acrylates include 2-ethylhexyl methacrylate in the concentration of 40-100% by weight based on the total weight of said alkyl (meth)acrylates. The preparation makes it possible for nitroglycerin to be absorbed percutaneously at a controlled rate for a long period of time. Also, even a compact preparation can supply a sufficient amount of nitroglycerin.Type: GrantFiled: April 4, 1991Date of Patent: November 9, 1993Assignees: Sekisui Kagaku Kogyo Kabushiki Kaisha, Sanwa Kagaku Kenkyusho Co., Ltd., Nippon Oil & Fats Co., Ltd.Inventors: Takashi Nakagawa, Hiroko Tsukahara, Masayasu Kurono, Makoto Sato, Tsutomu Ishida, Kazushi Tokita, Mitsuji Nakano
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Patent number: 5260056Abstract: An organic germanium compound to be effectively used for curing AIDS or making AIDS asymtomatic in various forms is expressed by the following rational formula: ##STR1## wherein n is an integer of 1 or 2 or more, is in the form of a white acicular or needle crystal, shows a solubility of 1.570/100 ml in water at 25.degree. C. and exhibits a melting (decomposition) point of 240.degree. C.Type: GrantFiled: January 14, 1991Date of Patent: November 9, 1993Assignee: Sanwa Kagaku Kenkyusho Co. Ltd.Inventors: Kiichi Sawai, Masayasu Kurono, Takahiko Mitani, Naohisa Ninomiya, Yoshiro Ishiwata, Syoji Yokochi, Kyoichi Asano, Kaneo Yamada, Masashi Taki, Takashi Meguro, Mikio Minamitani, Takao Matumoto, Yuichi Shiokawa