Patents Assigned to SAOL INTERNATIONAL LIMITED
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Publication number: 20210128827Abstract: Method of safely refilling an implanted infusion pump. The method includes contacting a withdrawn fluid with a protein-detecting composition, detecting whether the protein-detecting composition experiences a reaction, and performing a refilling procedure if no reaction is detected.Type: ApplicationFiled: March 25, 2019Publication date: May 6, 2021Applicant: SAOL INTERNATIONAL LIMITEDInventors: David PENAKE, Sharon HAMM, Martin REYNELL
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Patent number: 10813900Abstract: Methods for preparing sterilized baclofen solutions include adjusting the pH to below a desired pH, and steam sterilizing the solution with adjusted pH, which results in the solution having the desired pH. Such solutions may also have low concentrations of 4-CPP. Injectable baclofen solutions having greater than 2 mg/mL baclofen include between 5 mM and 25 mM of a phosphate or sulfate species. The solution has an ionic strength equivalent of about 1.5 M NaCl. The present application also provides baclofen formulations for use in treating spasticity, brain injury, cerebral palsy, spinal cord injury, cervical injury, multiple sclerosis, thoracic injury, or withdrawal symptoms.Type: GrantFiled: August 19, 2019Date of Patent: October 27, 2020Assignee: SAOL INTERNATIONAL LIMITEDInventors: Michael C. Schmitz, Corinne Dominguez, Thomas E. Keene, Deanna S. Lane, Lanchi T. Le, Jianwei Li, Ngoc T. Lu, Carmen E. Snaza
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Patent number: 10792262Abstract: Pharmaceutical compositions including an active ingredient and a stabilizer, as well as methods of manufacture of the compositions, and methods of their use.Type: GrantFiled: July 29, 2019Date of Patent: October 6, 2020Assignee: SAOL INTERNATIONAL LIMITEDInventors: David Penake, Sharon Hamm, Leonard O'Mahony, John Devane, Wolfgang Mohr, Manuel Weinheimer
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Patent number: 10751312Abstract: Pharmaceutical compositions including an active ingredient and a stabilizer, as well as methods of manufacture of the compositions, and methods of their use.Type: GrantFiled: July 29, 2019Date of Patent: August 25, 2020Assignee: SAOL INTERNATIONAL LIMITEDInventors: David Penake, Sharon Hamm, Leonard O'Mahony, John Devane, Wolfgang Mohr, Manuel Weinheimer
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Publication number: 20200261377Abstract: Phenol formulations including phenol and an encapsulation agent, such as a cyclodextrin or derivatives thereof, and uses of such formulations.Type: ApplicationFiled: January 29, 2020Publication date: August 20, 2020Applicant: SAOL INTERNATIONAL LIMITEDInventors: Leonard O'MAHONY, Sharon HAMM, John DEVANE, Imran AHMED, David PENAKE
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Publication number: 20200179598Abstract: Method of safely refilling or accessing a reservoir of an implanted fluid delivery device. The method includes guiding a bent or angled needle into the reservoir while observing an image the implanted fluid delivery device and with the bent or angled needle being oriented in a direction that faces away from an imaging device probe oriented in a substantially vertical orientation and overlying the implanted fluid delivery device.Type: ApplicationFiled: August 7, 2018Publication date: June 11, 2020Applicant: SAOL INTERNATIONAL LIMITEDInventors: David PENAKE, Michael SAULINO
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Publication number: 20200078327Abstract: Methods for preparing sterilized baclofen solutions include adjusting the pH to below a desired pH, and steam sterilizing the solution with adjusted pH, which results in the solution having the desired pH. Such solutions may also have low concentrations of 4-CPP. Injectable baclofen solutions having greater than 2 mg/mL baclofen include between 5 mM and 25 mM of a phosphate or sulfate species. The solution has an ionic strength equivalent of about 1.5 M NaCl. The present application also provides baclofen formulations for use in treating spasticity, brain injury, cerebral palsy, spinal cord injury, cervical injury, multiple sclerosis, thoracic injury, or withdrawal symptoms.Type: ApplicationFiled: August 19, 2019Publication date: March 12, 2020Applicant: SAOL INTERNATIONAL LIMITEDInventors: Michael C. SCHMITZ, Corinne DOMINGUEZ, Thomas E. KEENE, Deanna S. LANE, Lanchi T. LE, Jianwei LI, Ngoc T. LU, Carmen E. SNAZA
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Patent number: 10434248Abstract: Protein detection kit usable with implanted infusion pumps. The kit includes at least one container containing a protein-detecting composition and having an interface for allowing fluid to be introduced and a visual indicating mechanism for providing a visual indicator indicative of protein detection.Type: GrantFiled: March 26, 2018Date of Patent: October 8, 2019Assignee: Saol International LimitedInventors: David Allen Penake, Sharon Hamm, Martin Reynell
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Publication number: 20190290839Abstract: Protein detection kit usable with implanted infusion pumps. The kit includes at least one container containing a protein-detecting composition and having an interface for allowing fluid to be introduced and a visual indicating mechanism for providing a visual indicator indicative of protein detection.Type: ApplicationFiled: March 26, 2018Publication date: September 26, 2019Applicant: SAOL INTERNATIONAL LIMITEDInventors: David Allen PENAKE, Sharon HAMM, Martin REYNELL
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Patent number: 10420740Abstract: Methods for preparing sterilized baclofen solutions include adjusting the pH to below a desired pH, and steam sterilizing the solution with adjusted pH, which results in the solution having the desired pH. Such solutions may also have low concentrations of 4-CPP. Injectable baclofen solutions having greater than 2 mg/mL baclofen include between 5 mM and 25 mM of a phosphate or sulfate species. The solution has an ionic strength equivalent of about 1.5 M NaCl. The present application also provides baclofen formulations for use in treating spasticity, brain injury, cerebral palsy, spinal cord injury, cervical injury, multiple sclerosis, thoracic injury, or withdrawal symptoms.Type: GrantFiled: August 20, 2018Date of Patent: September 24, 2019Assignee: SAOL INTERNATIONAL LIMITEDInventors: Michael C. Schmitz, Corinne Dominguez, Thomas E. Keene, Deanna S. Lane, Lanchi T. Le, Jianwei Li, Ngoc T. Lu, Carmen E. Snaza
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Patent number: 10076506Abstract: Methods for preparing sterilized baclofen solutions include adjusting the pH to below a desired pH, and steam sterilizing the solution with adjusted pH, which results in the solution having the desired pH. Such solutions may also have low concentrations of 4-CPP. Injectable baclofen solutions having greater than 2 mg/mL baclofen include between 5 mM and 25 mM of a phosphate or sulfate species. The solution has an ionic strength equivalent of about 1.5 M NaCl. The present application also provides baclofen formulations for use in treating spasticity, brain injury, cerebral palsy, spinal cord injury, cervical injury, multiple sclerosis, thoracic injury, or withdrawal symptoms.Type: GrantFiled: February 7, 2017Date of Patent: September 18, 2018Assignee: SAOL INTERNATIONAL LIMITEDInventors: Michael C. Schmitz, Corinne Dominguez, Thomas E. Keene, Deanna S. Lane, Lanchi T. Le, Jianwei Li, Ngoc T. Lu, Carmen E. Snaza
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Publication number: 20170304242Abstract: Methods for preparing sterilized baclofen solutions include adjusting the pH to below a desired pH, and steam sterilizing the solution with adjusted pH, which results in the solution having the desired pH. Such solutions may also have low concentrations of 4-CPP. Injectable baclofen solutions having greater than 2 mg/mL baclofen include between 5 mM and 25 mM of a phosphate or sulfate species. The solution has an ionic strength equivalent of about 1.5 M NaCl. The present application also provides baclofen formulations for use in treating spasticity, brain injury, cerebral palsy, spinal cord injury, cervical injury, multiple sclerosis, thoracic injury, or withdrawal symptoms.Type: ApplicationFiled: February 7, 2017Publication date: October 26, 2017Applicant: SAOL INTERNATIONAL LIMITEDInventors: Michael C. SCHMITZ, Corinne DOMINGUEZ, Thomas E. KEENE, Deanna S. LANE, Lanchi T. LE, Jianwei LI, Ngoc T. LU, Carmen E. SNAZA
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Patent number: 9597304Abstract: Methods for preparing sterilized baclofen solutions include adjusting the pH to below a desired pH, and steam sterilizing the solution with adjusted pH, which results in the solution having the desired pH. Such solutions may also have low concentrations of 4-CPP. Injectable baclofen solutions having greater than 2 mg/mL baclofen include between 5 mM and 25 mM of a phosphate or sulfate species. The solution has an ionic strength equivalent of about 1.5 M NaCl. The present application also provides baclofen formulations for use in treating spasticity, brain injury, cerebral palsy, spinal cord injury, cervical injury, multiple sclerosis, thoracic injury, or withdrawal symptoms.Type: GrantFiled: November 6, 2015Date of Patent: March 21, 2017Assignee: SAOL INTERNATIONAL LIMITEDInventors: Michael C. Schmitz, Corinne Dominguez, Thomas E. Keene, Deanna S. Lane, Lanchi T. Le, Jianwei Li, Ngoc T. Lu, Carmen E. Snaza