Abstract: An anti-ligature handle and escutcheon mechanism mountable on a door for operating a lock for securing the door. The mechanism comprises a handle movable between open and closed positions, the handle having a smoothly curved outer surface to prevent the attachment of a ligature thereto and comprising a pivot at a first end for rotating the handle between the open and closed positions to operate the lock. An escutcheon fixed relative to a backing plate is oriented for mounting parallel to the door when the mechanism is mounted on an outer surface of the door, wherein the escutcheon surrounds the handle and defines a recessed area within which the handle pivots. The handle further has a second end including a guide which is trapped beneath and slides along an arcuate edge of the recessed area of the escutcheon to maintain flush contact between a mating surface of the handle and the backing plate to prevent ligatures from being inserted therebetween as the handle rotates to operate the lock.