Abstract: The present invention relates to a particulate biodegradable matrix comprising a biodegradable and hydrophilic core with a base of carbohydrate or polyol or polyamine matrix, cross-linked and derived in the mass by variable amounts of ionic groups; a hydrophilic polymer layer associated with the central core by chemical, for example ionic, interaction; and surface molecules or polymers grafted on the external polymer layer by covalent bonds.
Type:
Grant
Filed:
March 14, 2000
Date of Patent:
February 12, 2002
Assignee:
SARL Kappa Biotech
Inventors:
Philippe Mercier, Marianne Peyrot, Karim Ioualalen