Abstract: An automated single-use filtration device, in particular for large-volume filtration processes, comprises an unfiltrate inlet, one or more filter elements, a filtrate outlet and sensors for detecting specific process parameters and regulating mechanisms for adjusting specific process parameters. The sensors and regulating mechanisms are connected to an external monitoring and control system, which is adapted for evaluating and processing sensor data and for piloting the regulating mechanisms based on one or more control algorithms.

Abstract: A connection mechanism for a suction device for vacuum membrane filtration applications, includes a support for receiving a membrane filter or a filtration base, a cavity formed below the membrane filter or the filtration base, a suction duct which opens centrally into the cavity, and a ventilation duct which opens laterally into the cavity. The connection mechanism further includes a closing element which can be moved into several switching positions and which can block or unblock both the suction duct and the ventilation duct depending on the switching positions.

Abstract: The invention relates to a sterile connector for the sterile transfer of a liquid medium, in particular a biological medium, from a liquid container (2) into a fluid chamber (3, 3), wherein the sterile connector (1) has a first coupling device (5) and a second coupling device (6).

Abstract: A device (1) for accommodating a disposable container (44) has a receptacle (10) with at least one receptacle wall (16) that defines an interior of the receptacle (10) for accommodating the disposable container (44). The device includes a temperature control unit for controlling the temperature of the receptacle wall (16). A lighting device (50) is located on an inner face of the receptacle wall (16) that faces the interior of the receptacle (10) and that has the temperature controlled by the temperature control unit. The lighting device (50) is designed to emit light into the interior of the receptacle (10).

Abstract: The invention relates to a pinch valve comprising a valve element (4) with precisely one flow channel (20) that is surrounded by a circumferential wall (21) and has an inlet opening (24), which is designed for connecting a connection member (2) or which adjoins a connection element (2a), at a first end and an outlet opening (25), which is designed for connecting a connection member (2) or adjoins a connection element (2a), at a second end. The valve element (4) additionally has a pair of force transmitting elements (19, 19?) or a force transmitting element (19) and a fixing element (26) which are connected to the circumferential wall (21) in a central closing region (18) that is arranged between the inlet opening and the outlet opening. The force transmitting elements (19, 19?) or the force transmitting element (19) and the fixing element (26) are arranged at least substantially perpendicularly to the flow direction of the flow channel (20).

Abstract: A chromatography method, a method of determining the concentration of at least one compound in a chromatography method and a method of obtaining at least one chromatography method parameter are provided. The methods can include selecting at least one compound, a stationary phase, a mobile phase, and/or a chromatography device having a chromatography bed comprising the stationary phase and the mobile phase.

Abstract: Chromatography methods, methods of determining the concentration of at least one compound in a chromatography method and methods of obtaining at least one chromatography method parameter are provided. The chromatography methods include performance based on results obtained from the methods of determining the concentration of at least one compound or methods of obtaining at least one chromatography method parameter.

Abstract: The present invention relates to a method for producing a porous membrane, the method being characterized in that a solvent system comprising 2-pyrrolidone and N-alkyl-2-pyrrolidone is used, wherein the content ratio of 2-pyrrolidone to N-alkyl-2-pyrrolidone in the solvent system is from 90%:10% to 10%:90%, based on mass %, and wherein N-alkyl-2-pyrrolidone is N-propyl-2-pyrrolidone and/or N-butyl-2-pyrrolidone. Furthermore, the present invention relates to a porous membrane obtainable by said method. Moreover, the present invention relates to the use of a specific solvent system for the production of a porous membrane.

Abstract: A chromatography medium includes a porous matrix and nonporous globules bound on the inner and outer surfaces of the porous matrix. The average radius of the microglobules is not more than 30% of the average pore diameter of the porous matrix. The chromatography medium can be used in affinity chromatography. A method for preparing the chromatography medium may include providing a porous starting matrix, providing a polymerization solution, and initiating polymerization of the polymerization solution in the presence of the porous starting matrix to form insoluble nonporous microglobules that are bound to the inner and outer surfaces of the porous starting matrix.

Abstract: The present invention relates to a crossflow filtration method, a method for obtaining at least one crossflow filtration parameter and a system for obtaining at least one crossflow filtration parameter.

Abstract: A single-use chamber comprising a primary subchamber containing at least one primary component configured to perform an operation comprising at least one of generation and handling of a biological material; and a secondary subchamber containing at least one of a connection to equipment external to the single-use chamber and a secondary component, wherein the external equipment and the secondary component are configured to support the operation of the at least one primary component; wherein the primary subchamber and the secondary subchamber are configured to be connected to each other so that the at least one primary component is operatively coupled to at least one of the connection and the secondary component.

Abstract: A device (1) for producing a solution of at least one liquid first medium and at least one second medium has a first container (2) for the first medium and a second container (3) for the second medium. Each container (2, 3) is connected to a supply line of a static mixer (9) via a pump (4, 5) that can be regulated by a controller (6). A sensor (10) is connected to the controller (6) downstream of the static mixer (9) in the flow direction. A branching valve (17) is downstream of the static mixer (9) in the flow direction and is controlled by the controller (6). A sterile filter (11) is downstream of the static mixer (9) and has an RFID tag (15) that stores process-relevant data to at least be read by the controller (6). A method also is provided for producing a solution using the device.

Abstract: A container for storing, mixing and/or cultivating a medium, in particular a bioreactor for a medium, comprises a line system as a discharge line, feed line and/or bypass line of the bioreactor. The system can comprise a line body formed as a single piece for a medium to flow therethrough. The has a first and a second connection region for connecting in particular to the container and/or the line system and at least a first and a second coupling apparatus in the region between the connection regions.

Abstract: The present invention relates to a system comprising a mixing device for mixing the content of a bioreactor. The system is comprising at least one movement device for initiating a mixing movement in the bioreactor or in a holder for receiving a bioreactor and at least one sensor that can be arranged in or on the bioreactor for receiving at least one physiological or physical measurement variable. The mixing device or the bioreactor further comprises a sensor or transmitter for generating a synchronization measurement variable.

Abstract: A filtration system (1) has a filtration unit (2) with at least one filter element (4) for filtration of a fluid. The at least one filter element (4) has a main flow direction (C) for the fluid. The filtration unit (2) is configured to tilt the at least one filter element (4) around a tilting axis (B) to change an orientation of the main flow direction (C). A main unit (3) is fluidly connectable to the filtration unit (2) and includes a supply unit (18) configured to supply the fluid to the at least one filter element (4). A control unit is configured to control supplying and/or evacuating the fluid to/from the at least one filter element (4) and to control tilting of the at least one filter element (4) around the tilting axis (B).

Abstract: The invention relates to a bioprocess container (10) having an optical measuring device (100) for non-invasive spectroscopic measurement comprising: a container housing (12), a port housing (102), which is connected to the container housing (12) and is sealed off with respect to the interior (18) of the container housing (12); at least one radiation-emitting element (124), which is designed to transmit electromagnetic radiation through the at least one fluid contained in the container housing (12); at least one radiation-receiving element (126), which is designed to at least partly receive the radiation which was transmitted by the radiation-emitting element (124); and at least one measuring insert (122), which holds and supports the at least one radiation-emitting element (124) and/or the at least one radiation-receiving element (126).

Abstract: A chromatography method, a method of determining the concentration of at least one compound in a chromatography method and a method of obtaining at least one chromatography method parameter are provided. The methods can include selecting at least one compound, at least one stationary phase, at least one mobile phase, and at least one chromatography device having a chromatography bed comprising the at least one stationary phase and the at least one mobile phase.

Abstract: A protective device (5, 5?, 5?, 5??, 5??) is provided for a hose clip (4) that connects a hose end (2) to a hose connection (3). The protective device includes a protective body (8, 8?, 8?, 8??, 8??) made of a plastic. In the assembled state, the protective body (8, 8?, 8?, 8??, 8??) surrounds the circumference of the hose clip (4) and accommodates the hose clip (4) at least in its clamping region via a radially oriented molding (32), and covers the hose clip (4) over the width thereof extending in the longitudinal direction of the hose connection (3). The protective body (8, 8?, 8?, 8??, 8??) has ring segments (9, 10) that can be connected to one another at their free ends (12, 13), and the segments are connected moveably to one another at their ends (14, 17) facing away from the free ends (12, 13).

Abstract: The present invention relates to a multimodal adsorption medium, in particular a multimodal chromatography medium, a method for its production, as well as use of the adsorption medium according to the invention or an adsorption medium produced according to the invention for the purification of biomolecules.

Abstract: A valve includes a longitudinally movable valve body that is arranged in the valve, wherein the valve housing has at least two guide grooves, with which auxiliary guide elements, arranged on the valve body, engage an exterior surface of the valve housing. The guide grooves of the valve housing are shaped such that they define a combined translatory and rotary movement path of the valve body with the aid of the auxiliary guide elements in order to open or close the valve.