Abstract: Provided herein are methods of utilizing bile acid transport inhibitors and/or enteroendocrine peptide enhancing agents for the treatment of obesity, diabetes, and inflammatory gastrointestinal conditions.
Type:
Grant
Filed:
February 14, 2019
Date of Patent:
March 1, 2022
Assignee:
SATIOGEN PHARMACEUTICALS, INC.
Inventors:
Bronislava Gedulin, Andrew A. Young, Howard E. Greene
Abstract: Provided herein are methods of utilizing bile acid transport inhibitors and/or enteroendocrine peptide enhancing agents for the treatment of obesity, diabetes, and inflammatory gastrointestinal conditions.
Type:
Grant
Filed:
November 26, 2014
Date of Patent:
April 9, 2019
Assignee:
SATIOGEN PHARMACEUTICALS, INC.
Inventors:
Bronislava Gedulin, Andrew A. Young, Howard E. Greene
Abstract: Provided herein are methods of utilizing bile acid transport inhibitors and/or enteroendocrine peptide enhancing agents for the treatment of obesity, diabetes, and inflammatory gastrointestinal conditions.
Type:
Grant
Filed:
February 22, 2012
Date of Patent:
January 29, 2019
Assignee:
SATIOGEN PHARMACEUTICALS, INC.
Inventors:
Bronislava Gedulin, Andrew A. Young, Howard E. Greene
Abstract: Provided herein are methods and shunt devices for treating diabetes and obesity. Methods and shunt devices promote stimulation of secretion of intestinal L-cells and other enteroendocrine cell types. Enteroendocrine secretion is stimulated directly or indirectly by shunting bile and/or pancreatic secretion to segments of the gut more distal than would normally occur. The shunt device may be a flexible catheter that is impervious to such secretions, with a proximal end draining the pancreatic/bile duct, and a distal end residing distally within the lumen of the small or large intestine. The shunt may be inserted with minimally invasive techniques, such as by endoscopy or laparoscopy.
Abstract: Provided herein are methods of utilizing bile acid transport inhibitors and/or enteroendocrine peptide enhancing agents for the treatment of obesity, diabetes, and inflammatory gastrointestinal conditions.
Type:
Application
Filed:
February 22, 2012
Publication date:
March 7, 2013
Applicant:
Satiogen Pharmaceuticals, Inc.
Inventors:
Bronislava Gedulin, Andrew A. Young, Howard E. Greene
Abstract: Provided is a shunt device that promotes stimulation of secretion of intestinal L-cells and other enteroendocrine cell types. Enteroendocrine secretion is stimulated directly or indirectly by shunting bile and/or pancreatic secretion to segments of the gut more distal than would normally occur The shunt device may be a flexible catheter that is impervious to such secretions, with a proximal end draining the pancreatic/bile duct, and a distal end residing distally within the lumen of the small or large intestine. The shunt may be inserted with minimally invasive techniques, such as by endoscopy.
Abstract: Provided herein are methods of utilizing bile acid transport inhibitors and/or enteroendocrine peptide enhancing agents for the treatment of obesity, diabetes, and inflammatory gastrointestinal conditions.
Type:
Application
Filed:
May 26, 2011
Publication date:
December 1, 2011
Applicant:
Satiogen Pharmaceuticals, Inc.
Inventors:
Bronislava Gedulin, Andrew A. Young, Howard E. Greene
Abstract: Provided herein are methods of treating obesity and diabetes with labile bile acid sequestrants. An effective amount of a labile bile acid sequestrant may be orally administered to an obese or diabetic individual. A labile bile acid sequestrant provided herein may have a low affinity in the colon or rectum of a human for at least one bile acid or bile acid mimic that stimulates L-cells. A labile bile acid sequestrant may be a non-systemic labile bile acid sequestrant.
Type:
Application
Filed:
December 15, 2010
Publication date:
June 23, 2011
Applicant:
Satiogen Pharmaceuticals, Inc.
Inventors:
Bronislava GEDULIN, Howard E. Greene, JR.