Patents Assigned to Sato Pharmaceutical Research Institute Ltd.
  • Fluorine-containing protoporphyrin derivatives and their salts
    Patent number: 4916221
    Abstract: Disclosed herein is a fluorine-containing protoporphyrin derivative of formula (I): ##STR1## wherein R.sub.1 and R.sub.2 each independently is --CH.dbd.CH.sub.2 or --CH.dbd.CF.sub.2 with the proviso that R.sub.1 and R.sub.2 cannot both be --CH.dbd.CH.sub.2 ; and salts thereof.They have remarkable property of peculiarly concentrating or accumulating in the cancer tissues, and very useful as a diagnostic agent of minute cancer in a NMR diagnosis method.
    Type: Grant
    Filed: November 4, 1988
    Date of Patent: April 10, 1990
    Assignee: Sato Pharmaceutical Research Institute Ltd.
    Inventors: Itsumaro Kumadaki, Akira Ando, Haruo Sato
  • Method and apparatus for performing novel high-performance liquid chromatography
    Patent number: 4747686
    Abstract: This invention relates to an apparatus and a method of high performance liquid chromatography comprising irradiating a high performance liquid chromatography column and detecting separation conditions and separation patterns of a material charged onto said column by measuring the intensity of transmitted light, reflected light or fluorescent light from the column by means of a line sensor.
    Type: Grant
    Filed: July 25, 1986
    Date of Patent: May 31, 1988
    Assignee: SATO Pharmaceutical Research Institute Ltd.
    Inventor: Haruo Sato
  • Deuteroporphyrin derivative or salt thereof
    Patent number: 4634557
    Abstract: Disclosed herein is a deuteroporphyrin derivative represented by the following general formula: ##STR1## wherein one of R.sub.1 and R.sub.2 means --CH(CH.sub.3)--OR, R being a lower alkyl group, and the other denotes --CH.dbd.CH.sub.2, or R.sub.1 and R.sub.2 both mean --CH(CH.sub.3)--OR, R having the same meaning as defined above, or a salt thereof. The deuteroporphyrin derivative or its salt can be readily obtained in its pure form and is useful as a photosensitizer in the laser irradiation therapy of cancers.
    Type: Grant
    Filed: January 11, 1985
    Date of Patent: January 6, 1987
    Assignee: Sato Pharmaceutical Research Institute Ltd.
    Inventor: Haruo Sato