Abstract: Disclosed herein are particles of an active ingredient, a composition comprising the same, and a method for producing the same. The method disclosed herein comprises the steps of, (a) forming a first solution by dissolving the active ingredient in a first solvent; (b) forming the particles of the active ingredient by mixing a second solvent with the first solution to produce an emulsified solution. Moreover, the second solvent is miscible with the first solvent, but is immiscible with the first solution.
Type:
Application
Filed:
June 14, 2018
Publication date:
January 21, 2021
Applicant:
Savior Lifetec Corporation
Inventors:
Yan-Ming CHEN, Shih-Hsie PAN, Mannching Sherry KU, Chia-Hsin LIN
Abstract: Disclosed herein is a method for producing microparticles of an active ingredient via an in-line recirculating mixing system, wherein the in-line recirculating mixing system comprises a mixer and a conduit couple to the mixer. The method disclosed herein comprises the steps of: (a) forming a continuous phase of a medium in the in-line recirculating mixing system; (b) allowing the continuous phase of the medium of the step (a) to come into contact with a first mixture of the active ingredient, a polymer and a solvent at a site in the conduit, thereby forming a second mixture, in the conduit; and (c) allowing the second mixture of the step (b) to enter the mixer and circulate in the in-line recirculating mixing system until the microparticles of the active ingredient are formed.
Type:
Application
Filed:
January 23, 2018
Publication date:
December 19, 2019
Applicant:
Savior Lifetec Corporation
Inventors:
Amy LIU, Alex CHOU, Shih-Hsie PAN, Mannching Sherry KU
Abstract: Disclosed herein are expression constructs and methods for producing a protein of interest. According to some examples, an expression construct includes a nucleotide sequence encoding a fusion protein. To produce the protein of interest, the expression construct is transformed into a host cell, which is cultured under conditions that allow the expression of the fusion protein. The fusion protein has at least one expression unit; each expression unit has, sequentially, an affinity tag moiety, a spacer moiety, an enzymatic cleavage site, and a protein of interest moiety. The fusion protein is isolated from the host cell, solubilized, and refolded. The refolded fusion protein is cleaved to release the protein of interest.
Abstract: The present invention relates to an efficient process of synthesizing some known Ertapenem compounds and to provide new intermediate compounds of Meropenem and Doripenem. The process and the intermediate can substantially increase the effective yield and reduce the impurity generation. The present invention further provides a novel and effective process for recovering and purifying ertapenem compounds by utilizing a low cost, materials with chemical stability as a carrier for isolating ertapenem compounds from extracts.
Abstract: The present invention relates to a process for the preparation of carbapenem antibiotic compounds, which are useful for intravenous and intramuscular administration.
Abstract: The present invention relates to a process for the preparation of carbapenem antibiotic compounds, which is useful for intravenous and intramuscular administration.
Abstract: The present invention relates to a process for the preparation of carbapenem antibiotic compounds, which are useful for intravenous and intramuscular administration.
Abstract: The present invention relates to preparing carbapenem intermediates that are useful to produce Ertapenem, Meropenem and Doripenem; and provides an effective process for recovering ertapenem compounds.