Abstract: The present invention relates to a microfluidic particle analysis device comprising an inlet in fluid communication via a main channel defining a main flow direction with an inlet manifold providing parallel fluid communication with a bypass channel of hydrodynamic resistance Rbypass, and a measuring channel of hydrodynamic resistance Rmeasuring, the measuring channel having a cross-sectional dimension in the range of from 1 ?m to 50 ?m and further having a sensor system for detecting a particle, wherein a flow distribution parameter Xmeasuring=Rmeasuring?1(Rmeasuring?1+Rbypass?1)?1 is in the range from 10?6 to 0.25, wherein the angle of the measuring channel relative to the main flow direction is in the range of 0° to 60°, and wherein the angle of the bypass channel relative to the main flow direction is in the range of 0° to 60°, and the microfluidic particle analysis device further comprising an outlet in fluid communication with the bypass channel and the measuring channel.