Patents Assigned to Scanogen Inc.
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Patent number: 11860354Abstract: An imaging system is described for measuring the position or movement of a particle having a size of less than about 20 microns. The system comprises an optional sample holder configured to hold a sample with a particle, an optional illumination source configured to illuminate the sample, a lens having a magnification ratio from about 1:5 to about 5:1 and configured to generate the image of the sample, an image sensor having a pixel size of up to about 20 microns and configured to sense the image of the sample, and an image processor operatively connected to the image sensor to process the image of the particle in order to determine the position or movement of the particle. The dimension of the image of each particle is at least about 1.5 times the dimension of the particle multiplied by the magnification ratio of the lens, and the image of each particle is distributed on at least two pixels of the sensor. The imaged area of the sample is at least about one millimeter squared.Type: GrantFiled: May 12, 2022Date of Patent: January 2, 2024Assignee: Scanogen Inc.Inventors: Zhiguang Xu, Alfredo Andres Celedon
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Patent number: 11505818Abstract: The present application relates to detection units and methods for detecting one or more target analytes in a sample using a complex formed by a target and first and second probes, wherein the complex comprises an elongated region, a particle that is coupled to the first probe, and a solid support that is coupled to the second probe. Specific binding of a target analyte can be distinguished from non-specific binding of the particle by measuring the displacement of the particle.Type: GrantFiled: December 12, 2018Date of Patent: November 22, 2022Assignee: Scanogen Inc.Inventors: Alfredo Andres Celedon, Saravana Radha Krishna Murthy, Zhiguang Xu, Danielle Elise Schultz, Troy Allen Horn
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Patent number: 11371986Abstract: The present application relates to detection units and methods for detecting one or more target analytes in a sample using a complex formed by a target and first and second probes, wherein the first probe is coupled to a detectable piece, the target is coupled to the first probe and the second probe, and the second probe is coupled to a solid support. Specific binding of the detectable piece to the target analyte can be distinguished from non-specific binding of the detectable piece by measuring the number of detectable pieces that leave their initial location after exposure to a disruptor that uncouples the detectable piece from the solid support.Type: GrantFiled: May 23, 2019Date of Patent: June 28, 2022Assignee: SCANOGEN INC.Inventors: Alfredo A. Celedon, Joseph P. Russell
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Patent number: 11360296Abstract: An imaging system is described for measuring the position or movement of a particle having a size of less than about 20 microns. The system comprises an optional sample holder configured to hold a sample with a particle, an optional illumination source configured to illuminate the sample, a lens having a magnification ratio from about 1:5 to about 5:1 and configured to generate the image of the sample, an image sensor having a pixel size of up to about 20 microns and configured to sense the image of the sample, and an image processor operatively connected to the image sensor to process the image of the particle in order to determine the position or movement of the particle. The dimension of the image of each particle is at least about 1.5 times the dimension of the particle multiplied by the magnification ratio of the lens, and the image of each particle is distributed on at least two pixels of the sensor. The imaged area of the sample is at least about one millimeter squared.Type: GrantFiled: September 4, 2020Date of Patent: June 14, 2022Assignee: Scanogen IncInventors: Zhiguang Xu, Alfredo Andres Celedon
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Patent number: 10768406Abstract: An imaging system is described for measuring the position or movement of a particle having a size of less than about 20 microns. The system comprises an optional sample holder configured to hold a sample with a particle, an optional illumination source configured to illuminate the sample, a lens having a magnification ratio from about 1:5 to about 5:1 and configured to generate the image of the sample, an image sensor having a pixel size of up to about 20 microns and configured to sense the image of the sample, and an image processor operatively connected to the image sensor to process the image of the particle in order to determine the position or movement of the particle. The dimension of the image of each particle is at least about 1.5 times the dimension of the particle multiplied by the magnification ratio of the lens, and the image of each particle is distributed on at least two pixels of the sensor. The imaged area of the sample is at least about one millimeter squared.Type: GrantFiled: February 28, 2017Date of Patent: September 8, 2020Assignee: Scanogen Inc.Inventors: Zhiguang Xu, Alfredo Andres Celedon
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Publication number: 20190112641Abstract: The present application relates to detection units and methods for detecting one or more target analytes in a sample using a complex formed by a target and first and second probes, wherein the complex comprises an elongated region, a particle that is coupled to the first probe, and a solid support that is coupled to the second probe. Specific binding of a target analyte can be distinguished from non-specific binding of the particle by measuring the displacement of the particle.Type: ApplicationFiled: December 12, 2018Publication date: April 18, 2019Applicant: Scanogen Inc.Inventors: Alfredo Andres Celedon, Saravana Radha Krishna Murthy, Zhiguang Xu, Danielle Elise Schultz, Troy Allen Horn
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Patent number: 10179930Abstract: The present application relates to detection units and methods for detecting one or more target analytes in a sample using a complex formed by a target and first and second probes, wherein the complex comprises an elongated region, a particle that is coupled to the first probe, and a solid support that is coupled to the second probe. Specific binding of a target analyte can be distinguished from non-specific binding of the particle by measuring the displacement of the particle.Type: GrantFiled: February 5, 2015Date of Patent: January 15, 2019Assignee: Scanogen Inc.Inventors: Alfredo Andres Celedon, Saravana Radha Krishna Murthy, Zhiguang Xu, Danielle Elise Schultz, Troy Allen Horn
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Publication number: 20160258003Abstract: The present application relates to detection units and methods for detecting one or more target analytes in a sample using a complex formed by a target and first and second probes, wherein the complex comprises an elongated region, a particle that is coupled to the first probe, and a solid support that is coupled to the second probe. Specific binding of a target analyte can be distinguished from non-specific binding of the particle by measuring the displacement of the particle.Type: ApplicationFiled: February 5, 2015Publication date: September 8, 2016Applicant: Scanogen Inc.Inventors: Alfredo Andres Celedon, Saravana Radha Krishna Murthy, Zhiguang Xu, Danielle Elise Schultz, Troy Allen Horn
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Patent number: 9382580Abstract: Detection units and methods for detecting one or more target analytes in a sample are disclosed. The detection unit provides a first and second surface connected by a filament which is capable of binding the target analyte in the sample. The methods provide for the detection of the target analyte through the generation of a detectable signal following the binding of the target analyte to the filament.Type: GrantFiled: October 10, 2012Date of Patent: July 5, 2016Assignee: Scanogen Inc.Inventor: Alfredo Andres Celedon
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Patent number: 9382578Abstract: The present application relates to detection units and methods for detecting one or more target analytes in a sample. In certain embodiments, the detection unit provides a first and second surface connected by a filament which is capable of binding the target analyte in the sample. In other embodiments, the detection unit provides a circular molecule capable of binding the target analyte and accumulating torsional stress in the presence of a twisting agent. The methods provide for the detection of the target analyte through the generation of a detectable signal following the binding of the target analyte to the filament.Type: GrantFiled: September 24, 2013Date of Patent: July 5, 2016Assignee: Scanogen Inc.Inventor: Alfredo Andres Celedon