Patents Assigned to Scarab Genomics, LLC
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Patent number: 12385035Abstract: The current invention provides a synthetic prokaryotic genome comprising 5 or fewer occurrences of one or more sense codons; and/or a synthetic prokaryotic genome derived from a parent genome, wherein the synthetic prokaryotic genome comprises less than 10%, 5%, 2%, 1%, 0.5%, 0.1% of the occurrences of one or more sense codons, relative to the parent genome; and/or a synthetic prokaryotic genome comprising 100 or more, 200 or more, or 1000 or more genes with no occurrences of one or more sense codons.Type: GrantFiled: May 14, 2020Date of Patent: August 12, 2025Assignees: United Kingdom Research and Innovation, Scarab Genomics, LLCInventors: Julius Fredens, Kaihang Wang, Daniel De La Torre, Louise F. H. Funke, Wesley E. Robertson, Jason W. Chin
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Patent number: 12378547Abstract: The current invention provides a synthetic prokaryotic genome comprising 5 or fewer occurrences of one or more sense codons; and/or a synthetic prokaryotic genome derived from a parent genome, wherein the synthetic prokaryotic genome comprises less than 10%, 5%, 2%, 1%, 0.5%, 0.1% of the occurrences of one or more sense codons, relative to the parent genome; and/or a synthetic prokaryotic genome comprising 100 or more, 200 or more, or 1000 or more genes with no occurrences of one or more sense codons.Type: GrantFiled: October 24, 2023Date of Patent: August 5, 2025Assignees: United Kingdom Research and Innovation, Scarab Genomics, LLCInventors: Julius Fredens, Kaihang Wang, Daniel De La Torre, Louise F. H. Funke, Wesley E. Robertson, Jason W. Chin
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Patent number: 11970725Abstract: Provided herein are E. coli host strains with improved capacity for producing recombinant proteins.Type: GrantFiled: April 12, 2023Date of Patent: April 30, 2024Assignee: Scarab Genomics LLCInventors: Frederick R. Blattner, Robert E. Novy, David A. Frisch, Charles Landry, Hyunsic Choi, Eric A. Steffen, John Brandon
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Publication number: 20200216798Abstract: Methods and compositions for long term continuous flow fermentation using a two vessel continuous culture fermentation apparatus are described.Type: ApplicationFiled: March 19, 2020Publication date: July 9, 2020Applicant: Scarab Genomics, LLCInventor: Frederick R. BLATTNER
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Publication number: 20180087018Abstract: A two-vessel continuous flow system in conjunction with low mutation reduced genome bacterial strains provides a platform for long term extended fermentations. Such systems require modification of standard fermentation devices such as probes, pumps and monitoring systems as well as improved procedures for feed delivery, culture monitoring and product harvesting methods. An optimized two-vessel system for producing large quantities of fermentation products from small volume, long duration continuous fermentations represents a significant improvement over existing fermentation strategies. Methods and compositions for long term continuous flow fermentation using a two vessel continuous culture fermentation apparatus are described.Type: ApplicationFiled: April 1, 2016Publication date: March 29, 2018Applicant: Scarab Genomics, LLCInventor: Frederick R. BLATTNER
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Patent number: 8900849Abstract: The present invention relates to novel strains of microorganisms with oxygen-regulated metabolism. The microorganisms have higher growth rates and are more efficient than parental strains. The microorganisms may be used to produce a variety of products of interests, such as recombinant proteins, nucleic acids, such as DNA, amino acids, and chemicals.Type: GrantFiled: September 8, 2006Date of Patent: December 2, 2014Assignee: Scarab Genomics, LLCInventors: Frederick R. Blattner, John Walter Campbell, Nian Shi, Buffy Stahl
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Patent number: 8367380Abstract: The present invention relates generally to compositions and methods useful for, inter alia, production of commercial biologic products such as amino acids. More specifically, the present invention relates to genetically modified strains of microorganisms and the use thereof for the production of commercial products. The present invention also provides, inter alia, novel isolated DNA, nucleic acid, vectors and reduced genome bacteria.Type: GrantFiled: February 19, 2009Date of Patent: February 5, 2013Assignee: Scarab Genomics LLCInventors: Frederick R. Blattner, Sun Chang Kim, Jun Hyoung Lee
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Patent number: 8178339Abstract: Reduced genome strains of E. coli MG1655 are described. In various embodiments, the strains have one or more of equal or improved growth rate, transformation efficiency, protein expression, DNA production, DNA yield and/or DNA quality compared to the parental strain and commercially available strains.Type: GrantFiled: August 18, 2006Date of Patent: May 15, 2012Assignee: Scarab Genomics LLCInventors: John W Campbell, Frederick R. Blattner, Guy Plunkett, Gyorgy Posfai
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Patent number: 7989181Abstract: The invention relates to host cells with improved protein expressed properties. The host cells comprise rare tRNA genes within the one or more rRNA operons.Type: GrantFiled: April 23, 2007Date of Patent: August 2, 2011Assignee: Scarab Genomics, LLCInventors: Frederick R. Blattner, John Walter Campbell, Guy Plunkett
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Publication number: 20110165680Abstract: Methods for introducing and expressing genes in animal cells are provided comprising infecting the animal cells with live invasive reduced-genome bacteria comprising a eukaryotic expression cassette comprising said gene. Also provided are methods for producing a pluripotent stem (iPS) cell from a mammalian somatic cell comprising infecting the somatic cell with live invasive reduced-genome bacteria comprising one or more eukaryotic expression cassettes comprising at least a gene encoding the transcription factor Oct3/4 and a gene encoding a member of the SRY-related HMG-box (Sox) transcription factor family.Type: ApplicationFiled: September 14, 2009Publication date: July 7, 2011Applicant: Scarab Genomics, LLCInventors: Frederick R. Blattner, Val Burland, Charles Landy, Nian-Qing Shi, Buffy Stahl
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Patent number: 7935505Abstract: The various embodiments of the present invention relate generally to plasmid DNA preparations and to methods for producing and using such preparations.Type: GrantFiled: May 24, 2007Date of Patent: May 3, 2011Assignee: Scarab Genomics, LLCInventors: Frederick R. Blattner, John Walter Campbell, Guy Plunkett
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Patent number: 7303906Abstract: The present invention discloses that a bacterium having a genome that is genetically engineered to be at least 10% smaller than the genome of its native parent strain has better transformation competence. Specific E. coli strains, having significantly reduced genome sizes, are disclosed which are highly transformation competent. A medium and methodology is taught which enables transformation efficiencies to be increased further.Type: GrantFiled: September 5, 2003Date of Patent: December 4, 2007Assignees: Wisconsin Alumni Research Foundation, Scarab Genomics, LLCInventors: Frederick R. Blattner, Gyorgy Posfai, Christopher D. Herring, Guy Plunkett, III, Jeremy Glasner, Trevor Twose