Patents Assigned to Scarab Genomics, LLC
  • Patent number: 12385035
    Abstract: The current invention provides a synthetic prokaryotic genome comprising 5 or fewer occurrences of one or more sense codons; and/or a synthetic prokaryotic genome derived from a parent genome, wherein the synthetic prokaryotic genome comprises less than 10%, 5%, 2%, 1%, 0.5%, 0.1% of the occurrences of one or more sense codons, relative to the parent genome; and/or a synthetic prokaryotic genome comprising 100 or more, 200 or more, or 1000 or more genes with no occurrences of one or more sense codons.
    Type: Grant
    Filed: May 14, 2020
    Date of Patent: August 12, 2025
    Assignees: United Kingdom Research and Innovation, Scarab Genomics, LLC
    Inventors: Julius Fredens, Kaihang Wang, Daniel De La Torre, Louise F. H. Funke, Wesley E. Robertson, Jason W. Chin
  • Patent number: 12378547
    Abstract: The current invention provides a synthetic prokaryotic genome comprising 5 or fewer occurrences of one or more sense codons; and/or a synthetic prokaryotic genome derived from a parent genome, wherein the synthetic prokaryotic genome comprises less than 10%, 5%, 2%, 1%, 0.5%, 0.1% of the occurrences of one or more sense codons, relative to the parent genome; and/or a synthetic prokaryotic genome comprising 100 or more, 200 or more, or 1000 or more genes with no occurrences of one or more sense codons.
    Type: Grant
    Filed: October 24, 2023
    Date of Patent: August 5, 2025
    Assignees: United Kingdom Research and Innovation, Scarab Genomics, LLC
    Inventors: Julius Fredens, Kaihang Wang, Daniel De La Torre, Louise F. H. Funke, Wesley E. Robertson, Jason W. Chin
  • Patent number: 11970725
    Abstract: Provided herein are E. coli host strains with improved capacity for producing recombinant proteins.
    Type: Grant
    Filed: April 12, 2023
    Date of Patent: April 30, 2024
    Assignee: Scarab Genomics LLC
    Inventors: Frederick R. Blattner, Robert E. Novy, David A. Frisch, Charles Landry, Hyunsic Choi, Eric A. Steffen, John Brandon
  • Publication number: 20200216798
    Abstract: Methods and compositions for long term continuous flow fermentation using a two vessel continuous culture fermentation apparatus are described.
    Type: Application
    Filed: March 19, 2020
    Publication date: July 9, 2020
    Applicant: Scarab Genomics, LLC
    Inventor: Frederick R. BLATTNER
  • Publication number: 20180087018
    Abstract: A two-vessel continuous flow system in conjunction with low mutation reduced genome bacterial strains provides a platform for long term extended fermentations. Such systems require modification of standard fermentation devices such as probes, pumps and monitoring systems as well as improved procedures for feed delivery, culture monitoring and product harvesting methods. An optimized two-vessel system for producing large quantities of fermentation products from small volume, long duration continuous fermentations represents a significant improvement over existing fermentation strategies. Methods and compositions for long term continuous flow fermentation using a two vessel continuous culture fermentation apparatus are described.
    Type: Application
    Filed: April 1, 2016
    Publication date: March 29, 2018
    Applicant: Scarab Genomics, LLC
    Inventor: Frederick R. BLATTNER
  • Patent number: 8900849
    Abstract: The present invention relates to novel strains of microorganisms with oxygen-regulated metabolism. The microorganisms have higher growth rates and are more efficient than parental strains. The microorganisms may be used to produce a variety of products of interests, such as recombinant proteins, nucleic acids, such as DNA, amino acids, and chemicals.
    Type: Grant
    Filed: September 8, 2006
    Date of Patent: December 2, 2014
    Assignee: Scarab Genomics, LLC
    Inventors: Frederick R. Blattner, John Walter Campbell, Nian Shi, Buffy Stahl
  • Patent number: 8367380
    Abstract: The present invention relates generally to compositions and methods useful for, inter alia, production of commercial biologic products such as amino acids. More specifically, the present invention relates to genetically modified strains of microorganisms and the use thereof for the production of commercial products. The present invention also provides, inter alia, novel isolated DNA, nucleic acid, vectors and reduced genome bacteria.
    Type: Grant
    Filed: February 19, 2009
    Date of Patent: February 5, 2013
    Assignee: Scarab Genomics LLC
    Inventors: Frederick R. Blattner, Sun Chang Kim, Jun Hyoung Lee
  • Patent number: 8178339
    Abstract: Reduced genome strains of E. coli MG1655 are described. In various embodiments, the strains have one or more of equal or improved growth rate, transformation efficiency, protein expression, DNA production, DNA yield and/or DNA quality compared to the parental strain and commercially available strains.
    Type: Grant
    Filed: August 18, 2006
    Date of Patent: May 15, 2012
    Assignee: Scarab Genomics LLC
    Inventors: John W Campbell, Frederick R. Blattner, Guy Plunkett, Gyorgy Posfai
  • Patent number: 7989181
    Abstract: The invention relates to host cells with improved protein expressed properties. The host cells comprise rare tRNA genes within the one or more rRNA operons.
    Type: Grant
    Filed: April 23, 2007
    Date of Patent: August 2, 2011
    Assignee: Scarab Genomics, LLC
    Inventors: Frederick R. Blattner, John Walter Campbell, Guy Plunkett
  • Publication number: 20110165680
    Abstract: Methods for introducing and expressing genes in animal cells are provided comprising infecting the animal cells with live invasive reduced-genome bacteria comprising a eukaryotic expression cassette comprising said gene. Also provided are methods for producing a pluripotent stem (iPS) cell from a mammalian somatic cell comprising infecting the somatic cell with live invasive reduced-genome bacteria comprising one or more eukaryotic expression cassettes comprising at least a gene encoding the transcription factor Oct3/4 and a gene encoding a member of the SRY-related HMG-box (Sox) transcription factor family.
    Type: Application
    Filed: September 14, 2009
    Publication date: July 7, 2011
    Applicant: Scarab Genomics, LLC
    Inventors: Frederick R. Blattner, Val Burland, Charles Landy, Nian-Qing Shi, Buffy Stahl
  • Patent number: 7935505
    Abstract: The various embodiments of the present invention relate generally to plasmid DNA preparations and to methods for producing and using such preparations.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: May 3, 2011
    Assignee: Scarab Genomics, LLC
    Inventors: Frederick R. Blattner, John Walter Campbell, Guy Plunkett
  • Patent number: 7303906
    Abstract: The present invention discloses that a bacterium having a genome that is genetically engineered to be at least 10% smaller than the genome of its native parent strain has better transformation competence. Specific E. coli strains, having significantly reduced genome sizes, are disclosed which are highly transformation competent. A medium and methodology is taught which enables transformation efficiencies to be increased further.
    Type: Grant
    Filed: September 5, 2003
    Date of Patent: December 4, 2007
    Assignees: Wisconsin Alumni Research Foundation, Scarab Genomics, LLC
    Inventors: Frederick R. Blattner, Gyorgy Posfai, Christopher D. Herring, Guy Plunkett, III, Jeremy Glasner, Trevor Twose