Abstract: A peptide consisting of 5 to 30 amino acid residues, preferably 9 to 15, most preferably about 12 amino acid residues, comprising a B epitope of a poly-?2,8 sialic acid attached to NCAM which is recognized by an anti-poly-?2,8 sialic acid (PSA) antibody, the use thereof and the preparation of a medicament for modulating NCAM functions, to be administered for the prevention and/or the treatment of neurodegenerative diseases, brain and spine lesions, age-related learning and memory problems, and cancer is disclosed.
Type:
Grant
Filed:
July 18, 2008
Date of Patent:
November 1, 2011
Assignees:
Centre National de la Recherche Scientifique, Universite de la Mediterranee Aix-Marseilles 2, Schafer-N, Universitaetsklinikum Hamburg-Eppendorf
Abstract: The invention relates to the use of a peptide consisting of 5 to 30 amino acid residues, preferably 9 to 15, most preferably about 12 amino acid residues, said peptide comprising a B epitope of a poly-?2,8 sialic acid attached to NCAM, which is recognized by an anti-poly-?2,8 sialic acid (PSA) antibody, for the preparation of a medicament for modulating NCAM functions, to be administered for the prevention and/or the treatment of neurodegenerative diseases, brain and spine lesions, age-related learning and memory problems, and cancer.
Type:
Application
Filed:
July 18, 2008
Publication date:
April 23, 2009
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE LA MEDITERRANEE AIX MARSEILLE II, SCHAFER-N, UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Abstract: The invention relates to the use of a peptide consisting of 5 to 30 amino acid residues, preferably 9 to 15, most preferably about 12 amino acid residues, said peptide comprising a B epitope of a poly-?2,8 sialic acid attached to NCAM, which is recognized by an anti-poly-?2,8 sialic acid (PSA) antibody, for the preparation of a medicament for modulating NCAM functions, to be administered for the prevention and/or the treatment of neurodegenerative diseases, brain and spine lesions, age-related learning and memory problems, and cancer.
Type:
Grant
Filed:
October 16, 2003
Date of Patent:
August 26, 2008
Assignees:
Centre National de la Recherche Scientifique, Universite de la Mediterranee AIX-Marseille, Schafer-N, Universitaetsklinikum Hamburg-Eppendorf