Abstract: The symptoms of climacterium in male mammals, e.g., hypertension, cardiovascular disease and osteoporosis, are ameliorated by the administration to an afflicted individual one or both of a nitric oxide substrate and/or nitric acid donor, in combination with an androgen, an aromatase inhibitor or both, wherein the circulating levels of testosterone in the afflicted individual are increased.
Type:
Grant
Filed:
March 10, 1997
Date of Patent:
May 25, 1999
Assignees:
Schering Aktiengesellschaft and Board of Regents, The University of Texas System