Abstract: The present invention relates to a delivery system comprising a core and a membrane encasing said core, wherein said core and membrane consist essentially of an elastomer composition and said core comprises at least one therapeutically active agent. The delivery system is characterized in that the membrane comprises at least one regulating agent. The invention also relates to a method for controlling the release of at least one therapeutically active agent from a delivery system.

Abstract: The invention relates to an otorhinological delivery device comprising at least one pharmaceutically active agent. According to the invention the device comprises a core comprising said at least one pharmaceutically active agent wherein said core is made of an elastomer composition selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Siatoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof, and a membrane encasing said core, said membrane being made of a same or a different elastomer composition than said core, said elastomer composition being selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Siatoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof.

Abstract: A delivery system including a body construction (7) and at least one capsule (8) containing a pharmaceutical composition, the capsule having at least a first end and a second end. The body construction (7, 12, 34) has at least two locking parts (9, 10), each locking part (9, 10) having at least a first end and a second end, the first end of each locking part (9, 10) having a surface adapted to face and cover one of the at least first and second ends of the capsule (8). The diameter of at least one of the locking parts varies along its length between the first end and the second end, and the capsule (8) is mounted between the at least two locking parts. Also disclosed is a manufacturing process of a delivery system, the system including a body construction and at least one capsule containing a pharmaceutical composition.

Abstract: A disposable device for inserting one or more implants, the device including a tublar cannula (10) having a tip (11), the cannula also serving as a container for the implants, a plunger (20) and a handle (30) having a first end (31) directed towards the cannula, and a second end (32) directed away from the cannula. The plunger and handle are attached or attachable to each other in fixed manner, and the cannula is arranged to be movable in the longitudinal direction, so that the plunger is placed within. The cannula can, after inserting the implant or implants, be drawn on top of the plunger (20) so far that tip (11) becomes covered by handle (30) or by a piece connected to handle (30), and/or cannula (10) is, when drawn to its extreme position, towards second end (32) of handle (30), arranged to be irretrievably locked in relation to plunger (20).

Abstract: The invention relates to a method for the preparation of a siloxane-based elastomer composition comprising at least one elastomer, said elastomer composition comprising poly(alkylene oxide) groups present in the elastomer as alkoxy-terminated grafts of polysiloxane units and linked to the polysiloxane units by silicon-carbon bonds wherein at least one vinyl functional polymer component is crosslinked in the presence of a peroxide catalyst.

Abstract: A membrane or matrix for controlling the permeation rate of a drug, where the membrane or matrix includes a siloxane-based elastomer composition which contains at least one elastomer and optionally a non-crosslinked polymer. The elastomer composition includes poly(alkylene oxide) groups, and the poly(alkylene oxide) groups are present as blocks in a chain of the elastomer or the polymer, or as blocks and alkoxy-terminated grafts of polysiloxane units, the blocks or blocks and grafts being linked to the polysiloxane units by silicon-carbon bonds, with at least three blocks being present in the elastomer or polymer chain. Methods for the preparation of the elastomer composition are also disclosed.