Abstract: Nucleic acids encoding various proteases, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
Type:
Grant
Filed:
December 14, 1998
Date of Patent:
August 7, 2001
Assignee:
Schering-Plough
Inventors:
Blandine Marie de Saint-Vis, François Fossiez, Christophe Caux, Serge J. E. Lebecque
Abstract: Compositions and methods for using CTLA-8 to treat an abnormal physiological condition in an individual. The methods comprise administering a therapeutically effective amount of CTLA-8 alone, or in combination with other therapeutic reagents; or a CTLA-8 antagonist.
Type:
Grant
Filed:
October 24, 1996
Date of Patent:
May 16, 2000
Assignees:
Inserm, Institut National de la Sante et de la Recherche Medicale, Schering Corporation, Schering-Plough
Inventors:
Jacques Banchereau, Odile Djossou, Leopoldo Flores-Romo, Francois Fossiez, Pierre Golstein, Mala Krishna, Serge J. E. Lebecque, Richard Murray
Abstract: A method for purifying Interleukin-10 (Il-10) from a eukaryotic cell culture medium. The method is comprised of subjecting IL-10 containing cell culture medium to cation exchange chromatography, anion exchange chromatography, hydroxyapatite chromatography, and gel filtration chromatography. The present invention is also comprised of a process for separating different IL-10 dimers present in a protein fraction from each other by subjecting the protein fraction to hydroxyapatite chromatography. The present invention is also comprised of a process for separating variants of a protein differing in an N-terminal amino acid sequence present in a protein fraction from each other by subjecting the protein fraction to hydroxyapatite chromatography.
Type:
Grant
Filed:
March 5, 1993
Date of Patent:
July 12, 1994
Assignee:
Schering-Plough
Inventors:
Gary Vellekamp, Susan Cannon-Carlson, John Tang
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