Abstract: This invention relates to a novel process for the synthesis of Temozolomide, an antitumor compound, and analogs, and to intermediates useful in this novel process.
Type:
Grant
Filed:
September 26, 2008
Date of Patent:
June 15, 2010
Assignee:
Schering Plough Corp.
Inventors:
Shen-Chun Kuo, Janet L. Mas, Donald Chen-tung Hou
Abstract: A method is provided for extracting human interleukin-4 (IL-4) from IL-4 expressing bacterial cells. The method comprises treating the bacterial cells with a deactivating agent, disrupting the cell membrane and recovering the IL-4.
Abstract: There is disclosed an improved process for preparing albuterol which comprises reacting a 5-(haloacetyl)-2-hydroxybenzaldehyde with 1,1-dimethylethanamine in an organic solvent and in an inert atmosphere to form 5-[[(1,1-dimethylethyl)amino]acetyl]-2-hydroxybenzaldehyde and reducing the carbonyl functions to the corresponding hydroxy groups to form albuterol.
Type:
Grant
Filed:
November 3, 1989
Date of Patent:
August 28, 1990
Assignee:
Schering-Plough Corp.
Inventors:
Esther Babad, Nicholas Carruthers, Martin Steinman
Abstract: There is disclosed a compound represented by the formula ##STR1## wherein each P is hydrogen or a hydroxy protecting group and R and R' are each the same and are hydrogen, ##STR2## wherein R" is lower alkyl and R'" is a carboxy protecting group. The compounds are useful as intermediates for preparing penems.
Type:
Grant
Filed:
June 23, 1989
Date of Patent:
August 14, 1990
Assignee:
Schering-Plough Corp.
Inventors:
Donald Hou, Yee-Shing Wong, Dinesh Gala, Martin Steinman
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