Abstract: Topical compositions in gel form for the treatment of corns and calluses comprising a 7 to 13 carbon dicarboxylic acid and a pharmaceutically acceptable carrier, are described.

Abstract: A soft, tacky polysiloxane elastomer characterized as having: a tackiness of 10-450 grams as determined by a polyken probe tack tester or 0-10 cm (0-4 inches) as determined by a rolling ball tack tester and a tensile strength of 0.14-5.52 mega Pascals (20-800 pounds/square inch), a minimum elongation of 250-1100 percent and a tear strength of 0.88-35.2 kN/m (5-200 pound/square inch) The soft, tacky elastomer can be made into various cushioning devices, with or without a topcover. Representative cushioning devices include an arch support pad, a metatarsal pad, a heel cushion, sheet padding, a full-length insole, a three quarter length insole, a half insole, a toe-crest pad, a heel liner, an elbow pad, a corn pad, a callus pad, a blister pad, a bunion pad or a toe pad.

Abstract: An applicator 10 includes a barrel 12 for containing a semisolid medicinal, the barrel including a large diameter cylindrical section 16, a small diameter cylindrical section 18 and an annular sloped transition section 20 that connects the large diameter cylindrical section and the small diameter cylindrical section, the sections being coaxial with each other, the small diameter cylindrical section including an inner surface defining an internal cavity for containing the medicinal, a first end 30 with a first opening 32 and equiangularly spaced, axially aligned evacuation channels 28 in the inner surface for venting air out of the barrel when the internal cavity is filled with the medicinal, and the large diameter cylindrical section includes a second opposite end with a second opening 24; a rubber plunger 58 for pushing the medicinal through the first opening, the plunger being slidably positioned in sealing contact with the inner surface of the small diameter cylindrical section; a plunger rod 86 connected

Abstract: Gel film-forming flexible collodion compositions can be improved by including one or more topically acceptable polymers in an amount sufficient to increase the resilience of the film formed. Suitable polymers include polyalkylenes and (meth)acrylate homo- or copolymers. The compositions can further include salicylic acid and a topically acceptable crystallization inhibitor in an amount sufficient to suppress the crystallization of dissolved salicylic acid from the composition.

Abstract: A method for treating onychomycosis without drilling a hole in a nail plate or without daily scraping of the nail, comprising topically administering to the afflicted nail of a mammali) a medicated device comprising salicylic acid or a salt, ester or mixture thereof in a plaster preparation, wherein said plaster preparation is attached to a carrier and the salicylic acid is present in the plaster preparation in an amount ranging from about 10 to about 80 percent (%) by weight of the plaster preparation; orii) a liquid preparation comprising salicylic acid or a salt, ester or mixture thereof in a film-forming liquid vehicle, and the salicylic acid is present in the liquid preparation in an amount ranging from about 6 to about 35% by weight of the liquid preparation.

Abstract: Film-forming flexible collodion compositions can be improved by including one or more topically acceptable polymers in an amount sufficient to increase the resilience of the film formed. Suitable polymers include polyalkylenes and (meth)acrylate homo- or copolymers. The compositions can further include salicylic acid and a topically acceptable crystallization inhibitor in an amount sufficient to suppress the crystallization of dissolved salicylic acid from the composition.

Abstract: Apparatus for performing immunoassays which is essentially self-contained, requiring only the introduction of a sample and, at appropriate times, washing solution. The apparatus (10) includes: a fluid container (12) having a central platform area with a reaction area (30) which can contain a reactive agent; a sample receiving chamber (22) having a sample conduit (24) located above the porous medium; at least one openable reagent container (46); a conduit (28) for directing reagents onto the porous medium; an opening member (50) attached to the upper unit and positioned to contact and open reagent containers sequentially, by incremental relative rotation of the upper and base units; and a window (34) for viewing the reaction area. The apparatus can also include a sampler member (58) in the nature of a tampon for assays involving samples taken from body cavities.