Abstract: A production process for a prefilled, sterile syringe comprising providing a sterilized syringe barrel having sealable proximal and sealable distal ends. The proximal end being opened and the distal end being closed and adapted for coupling with a syringe outlet piece. In accordance with the process, the distal end of the barrel is closed and the barrel is then filled through the proximal end while the proximal end is opened with a fluid medium in the form of a liquid, a solution, a suspension or an emulsion wherein the barrel contains the fluid medium in a portion of the barrel and contains a gaseous medium in another portion of the barrel. After the barrel has been filled, a sterile plug is inserted through the proximal end of the barrel to close the proximal end. After pressing the plug into the barrel, the barrel is vented through a tube extending past the plug so that only the liquid medium is within the barrel.