Abstract: A syringe device for use with two components to be combined prior to discharge, comprising a syringe body without the proximal end, a syringe plunger rod threadedly engageable into a plunger and a lined seal for engagement with a needle hub. The syringe body has at the distal end a radially inwardly directed internal sealing ring dividing the body to define a distal chamber and a proximal chamber. Also provided is an internal bypass stopper sized to fit the syringe body and engage the sealing ring to sealingly separate the distal chamber and the proximal chamber. The stopper has a plurality of projections circumferentially spaced thereon for engagement with the syringe body on at least one side of the sealing ring. The projections define by-pass channels therebetween to permit flow of liquid from the proximal chamber to the distal chamber upon movement of the stopper toward the distal end.