Abstract: A method of filling pharmaceutical containers includes: filling a first plurality of containers, the first plurality of containers being supported by a first holder supported on a first step of a first transport and packaging container defining a first step height, the filling includes moving filling needles of a filling device to a filling needle height and dispensing a substance into each of the first plurality of containers; and filling a second plurality of containers, the second plurality of containers being supported by a second holder supported on a second step of a second transport and packaging container defining a second step height equal to the first step height, the filling includes moving the filling needles to the filling needle height and dispensing the substance into each of the second plurality of containers, the second plurality of containers differ from the first plurality of containers in at least one aspect.

Abstract: A method of treating a glass cylinder for a piston-cylinder arrangement for reducing the friction of a piston on an inner cylinder wall of the glass cylinder includes: elevating surface energy of glass of an interior bounded by the inner cylinder wall and hence lowering a contact angle of the glass with water. The contact angle is lowered by: a gas discharge that acts on the glass at the inner cylinder wall and is generated by an electric or electromagnetic field; or the action of ozone on the glass surface. The glass with the lowered contact angle is contacted with water to form a water film on the contacted glass.

Abstract: Packaging for the sterile storage and transport of objects for medical, pharmaceutical or cosmetic applications and a packaging process are provided. The packaging includes at least one bag made of a first and a second web, bonded to one another, a feature thereof being that the first web consists of a selectively permeable nonwoven fabric and that the second web consists of a laminated film with at least three layers, where the first layer is a polymer film arranged on the external side of the bag, the second layer is a lamination adhesive and the third layer is a polymer film arranged on the internal side of the bag. At least one of the layers of the second web includes one or more pigments. In an 8-bit greyscale image, the seal seam, imaged in transmitted light and contrast-standardized, is depicted within a greyscale value range of 50-200.

Abstract: Disclosed are films and a packaging for gas or vapor decontaminable packaging applications and a method for creating a sterile packaging using the same. These films are particularly useful for sterile storage and transport of objects for medical, pharmaceutical or cosmetic uses, in particular of sterile pharmaceutical primary packaging means, like vials, ampules, syringes, or cartridges. Said film comprises at least a layer of a selectively permeable non-woven, a layer of a punctured film, and an adhesive which can be activated by energy transmission. Optionally it comprises further film layers. The method for creating a sterile packaging comprises the step of hermetically closing the packaging by activating the adhesive thereby making the non-woven impermeable.

Abstract: A process for preparing a glass container that includes: providing a glass tube with a first portion, a second portion, and a longitudinal axis (Ltube); holding the first portion in a first clamping chuck and the second portion in a second clamping chuck; rotating the glass tube around the longitudinal axis (Ltube); heating, via a heater, the glass tube above a glass transition temperature; separating the first and second portions from one another by pulling apart along the longitudinal axis (Ltube) while the heated glass tube is still rotating by moving the first and the second chucks away from each other; and moving the heater, while moving the first and second chucks away from each other, so that the heater follows a mass that remains at a circular end region of the first and/or second portion.

Abstract: Disclosed are films and a packaging for gas or vapor decontaminable packaging applications and a method for creating a sterile packaging using the same. These films are particularly useful for sterile storage and transport of objects for medical, pharmaceutical or cosmetic uses, in particular of sterile pharmaceutical primary packaging means, like vials, ampules, syringes, or cartridges. Said film comprises at least a layer of a selectively permeable non-woven, a layer of a punctured film, and an adhesive which can be activated by energy transmission. Optionally it comprises further film layers. The method for creating a sterile packaging comprises the step of hermetically closing the packaging by activating the adhesive thereby making the non-woven impermeable.

Abstract: A receptacle includes an elongate barrel section defining a barrel length between an axial position pA and an axial position pB; side walls each having an inner surface bordering an interior; a layer of a lubricant located on the inner surface; and a charge present in the interior and sealing a cross section of the interior between the inner surfaces of the side walls. An axial position p+ is the axial position closest to pB at which the charge contacts the layer or the inner surfaces and an axial position p? is the axial position closest to pA at which the charge contacts the layer or the inner surfaces. The distance between pB and p+ divided by the distance between p+ and pA is in a range from 0 to 2 and a mean thickness of the layer between pA and p. is at least 10 nm.

Abstract: A substrate includes a first surface area; and a second surface area with a second roughness value. In a height profile of the substrate along a cutting line crossing the first surface area and the second surface area, a height of the substrate along a first section of the height profile is larger than the height of the substrate along a second section of the height profile. In the height profile an absolute value of a height difference between a point of maximum height or an averaged height, respectively, of the second section and a point of minimal height or an averaged height, respectively, of the first section defines a depth value. A ratio of the depth value and the second roughness value is between 2 and 35. A marking element extends across the first surface area and the second surface area.

Abstract: Disclosed are films and a packaging for gas or vapor decontaminable packaging applications and a method for creating a sterile packaging using the same. These films are particularly useful for sterile storage and transport of objects for medical, pharmaceutical or cosmetic uses, in particular of sterile pharmaceutical primary packaging means, like vials, ampules, syringes, or cartridges. Said film comprises at least a layer of a selectively permeable non-woven, a layer of a punctured film, and an adhesive which can be activated by energy transmission. Optionally it comprises further film layers. The method for creating a sterile packaging comprises the step of hermetically closing the packaging by activating the adhesive thereby making the non-woven impermeable.

Abstract: A receptacle includes: an elongate barrel section with an axial position p determined along an axis, the elongate barrel section extending from an axial position pA to an axial position pB; a side wall extending over the elongate barrel section and having an inner surface bordering an interior with a diameter; and a layer of a lubricant located on at least a part of the inner surface, a portion of the axis extends from a first axial position p1 to a second axial position p2; a mean thickness of the layer is determined in the portion; a position pm is the midpoint between p1 and p2; TA is a mean thickness of the layer for a section from p1 to pm; TB is a mean thickness of the layer for a section from pm to p2; a ratio TA:TB is in a range from 5:1 to 1:5.

Abstract: A pharmaceutical container includes an inner surface and an outer surface. At least part of the inner surface is coated with a coating to form a coated inner surface. On the coated inner surface the container, based on negative mode Time-of-Flight-Secondary Ion Mass Spectrometry (ToF-SIMS) data, has a relative lipid nanoparticle (LNP)-incubated Multivariate Curve Resolution (MCR) score ratio of lipid factor1 of less than 0.67.

Abstract: A process for the preparation of a glass container from a glass tube in a glass processing machine includes the steps of: I) heating the glass tube at a defined position between a first portion and a second portion to a temperature above a glass transition temperature of the glass tube while the glass tube is rotating around its longitudinal axis Ltube and pulling apart the first portion and the second portion thereby separating the first portion from the second portion and forming a closed bottom at one end of the first portion; and II) moving a mold matrix of the glass processing machine towards the closed bottom and bringing the mold matrix into contact with the closed bottom. While bringing the mold matrix into contact with the closed bottom, a distance Ym between the mold matrix and a first clamping chuck of the glass processing machine is decreased stepwise.

Abstract: A glass container includes a body region with a first end and a second end, the body region having an outer diameter (d1) and a glass thickness (s1), the body region being characterized by a longitudinal axis (Ltube) that passes through a center of the first and second end. When the glass container is standing on a support surface, h2 is the distance between the support surface up to the second end of the body region. The following condition is fulfilled: (A×X)/B=C. A is an axial load necessary to break the glass container to obtain fragments, X is a normalized area in cm2 defined as h2×d1×?+d12/4×?, B is a number of fragments of the glass container, and C is a fracture ratio. C is 40 N×cm2 or more and B is 30 or more.

Abstract: A glass container is characterized by a longitudinal axis (Ltube) that passes through a center of a glass bottom of the glass container. For any cut surface of the glass container that is obtainable by cutting the glass container in a plane that includes the longitudinal axis Ltube, a minimum thickness (smin) and a maximum thickness (smax) of the glass bottom determined at any position having a distance d1/4 or less to the longitudinal axis Ltube and a thickness (sd1/4) is the thickness of the glass bottom determined at a position having the distance d1/4 to the longitudinal axis Ltube, the distance to the longitudinal axis Ltube in each case being determined in a direction that is perpendicular to the longitudinal axis Ltube and thicknesses smin, smax and sd1/4 being determined in a direction that is parallel to longitudinal axis Ltube, with smax/smin being less than 1.8.

Abstract: A glass container for pharmaceutical compositions includes a hollow cylindrical body having at least one open end. At least a part of a surface of the glass container includes a coating. The coating has a crystallization temperature range and a melting temperature range determined using differential scanning calorimetry at a temperature change rate of 10° C./min. The crystallization temperature range and the melting temperature range overlap at a temperature of from ?75° C. to ?100° C.

Abstract: A glass syringe barrel is provided that has an at least partially conically shaped upper portion and a longitudinal axis. The glass syringe barrel has a top end through which a liquid can be ejected and a bottom end into which a plunger stopper can be pushed. The glass syringe barrel includes, in a direction from the top end to the bottom end, a cone, a shoulder region, and a body region. The shoulder region has and outer contour that has a concave and substantially circular arc-shaped area ci with an outer radius r1. The outer contour of the glass syringe barrel in the shoulder region is defined by a certain value for r1.

Abstract: A glass container is provided that includes a tube, a circular bottom, and a longitudinal axis. A curved glass heel extends from an outer end the bottom to the first end of the tube. The two-dimensional distance h(x,y) between a contact plane and the outer surface. The two-dimensional distance is measured in a direction parallel to the axis. The slope magnitude of the outer surface at the given position x,y is given by ?{square root over ((dh/dx)2+(dh/dy)2)}. The 75% quantile of values that have been determined for the term ?{square root over ((dh/dx)2+(dh/dy)2)}×d1/h(xy)delta for all given positions x,y within a circular area having a radius of 0.4×d2/2 and that correspond to the centre is less than 4100 ?m/mm. The adjacent positions x,y increase stepwise by 200 ?m, and h(x,y)delta=h(x,y)max?h(x,y)min, h(x,y)max is a maximum value for h(x,y) and h(x,y)min is a minimum value for h(x,y) being determined in that circular area.

Abstract: A method for producing a container includes identifying a location at a body, with the body at this location having a stress parameter which has a value less than or equal to a threshold value. The identifying includes deriving the threshold value from a simulation result of a simulation based on a finite element method of the stress parameter for a surface area and/or a volume area of the body with or without a marking element present, the identifying also includes obtaining a mean value by the simulation for the stress parameter for at least a part of at least one of the surface area or the volume area of the body. The threshold value is a sum of the mean value and 1000 % or less of an absolute value of the mean value. A marking element is provided which allows identification of the container at the identified location.

Abstract: A glass syringe barrel is provided that has an at least partially conically shaped upper portion and a longitudinal axis. The glass syringe barrel has a top end through which a liquid can be ejected and a bottom end into which a plunger stopper can be pushed. The glass syringe barrel includes, in a direction from the top end to the bottom end, a cone, a shoulder region, and a body region. The shoulder region has and outer contour that has a concave and substantially circular arc-shaped area c1 with an outer radius r1. The outer contour of the glass syringe barrel in the shoulder region is defined by a certain minimum value the radius of curvature.

Abstract: A method of forming a glass vial includes: locally heating one end of a glass tube; removing the locally heated end of the glass tube to form the glass vial having a closed base; and further forming the base of the glass vial, the further forming including generating a purge gas flow within the formed glass vial with the aid of a purge gas.