Abstract: A method for closing a container includes: providing the container including a neck and a crown, the crown including an upper crown surface; positioning a stopper including a flange and a plug, the flange including a lower flange surface and a flange height, such that the plug is positioned in the neck and the upper crown surface is in contact with the lower flange surface; exerting a force on the crown and the flange to form a horizontal contact area between the upper crown surface and the lower flange surface by a holding element such that the following conditions are fulfilled: the horizontal contact area has a size of 30 mm2 to 300 mm2; and the flange height is compressed at least partially in the horizontal contact area by 10% to 40%.

Abstract: A holding structure for simultaneously holding containers for pharmaceutical, medical, or cosmetic compositions includes: at least ten receptacles for receiving the containers and being formed by side walls; a flat base frame including a central recess; first webs running parallel to each other in a first direction across the central recess; second webs running parallel to each other in a second direction across the central recess, the first webs and the second webs being arranged such that the first webs and the second webs form the side walls, each of the first webs and the second webs being formed as a continuous beam having a maximum waviness wmax of 4.0 mm, the holding structure including a warpage of less than 2.0 mm as determined by a test method before steam sterilization, the warpage corresponding to a bending after the holding structure has been prepared and is empty.

Abstract: An apparatus for inspecting a pharmaceutical cylindrical container made of glass or of a polymer is provided. A corresponding method for inspecting the pharmaceutical cylindrical container made of glass or of a polymer and to a bundle of pharmaceutical cylindrical containers made of glass or of a polymer is also provided.

Abstract: A syringe includes a syringe body, a syringe cone having a distal opening, and a connection arranged in the region of the syringe cone, wherein the syringe body includes a first material and the connection includes a second material, and wherein the first material is different from the second material and the second material is a softer material than the first material.

Abstract: At least one system for storage of pharmaceutical compositions includes: a container including a neck and a crown that includes an upper crown surface; a stopper including a flange and a plug, the flange including a lower flange surface and a flange height; and a holding element configured to exert a force on the crown and the flange to form a horizontal contact area between the upper crown surface and the lower flange surface. The horizontal contact area has a size of 30 mm2 to 300 mm2 and the flange height is compressed at least partially in the horizontal contact area by 10% to 40%.

Abstract: A method of filling pharmaceutical containers includes: filling a first plurality of containers, the first plurality of containers being supported by a first holder supported on a first step of a first transport and packaging container defining a first step height, the filling includes moving filling needles of a filling device to a filling needle height and dispensing a substance into each of the first plurality of containers; and filling a second plurality of containers, the second plurality of containers being supported by a second holder supported on a second step of a second transport and packaging container defining a second step height equal to the first step height, the filling includes moving the filling needles to the filling needle height and dispensing the substance into each of the second plurality of containers, the second plurality of containers differ from the first plurality of containers in at least one aspect.

Abstract: A supporting structure for concurrently supporting a plurality of containers for substances for pharmaceutical, medical or cosmetic applications, comprises a plurality of receptacles. The receptacles are arranged in a regular arrangement, are formed by circumferential side-walls, and an upper side of the supporting structure is formed as a plate-shaped carrier. The receptacles are polygonal in shape when viewed in a plan view. A side-wall is formed as a common partition wall between respective two directly adjacent receptacles of the plurality of receptacles. The receptacles can be directly adjacent to each other, which enables optimum packing density, especially with a hexagonal basic shape of the receptacles. Due to the shared partition wall, filigree, double-walled structures can be effectively avoided, which considerably simplifies production by injection molding from a plastic material. Thereby, also a very high inherent stiffness of the supporting structure can be achieved.

Abstract: A holding structure includes receptacles formed by peripherally formed side walls, an annular gap being formed between a side wall of a container or device and one of the peripherally formed side walls when containers or devices are received therein, the receptacles being compressed in a first direction and expanded in a second direction transversely thereto, with the result that the gap is widened to form a widened clearance for handling containers or devices which are received in the receptacles, the holding structure further including an upper side, the peripherally formed side walls including an upper edge which forms a closed, smooth curve having at least one local maximum and at least one local minimum in a direction perpendicular to the upper side of the holding structure, the at least one local minimum being situated in a region of the widened clearance that is respectively assigned.

Abstract: A holding structure for simultaneously holding containers for pharmaceutical, medical, or cosmetic compositions includes: at least ten receptacles for receiving the containers and being formed by side walls; a flat base frame including a central recess; first webs running parallel to each other in a first direction across the central recess; second webs running parallel to each other in a second direction across the central recess, the first webs and the second webs being arranged such that the first webs and the second webs form the side walls, each of the first webs and the second webs being formed as a continuous beam having a maximum waviness wmax of 4.0 mm, the holding structure including a warpage of less than 2.0 mm as determined by a test method before steam sterilization, the warpage corresponding to a bending after the holding structure has been prepared and is empty.

Abstract: A method of treating a glass cylinder for a piston-cylinder arrangement for reducing the friction of a piston on an inner cylinder wall of the glass cylinder includes: elevating surface energy of glass of an interior bounded by the inner cylinder wall and hence lowering a contact angle of the glass with water. The contact angle is lowered by: a gas discharge that acts on the glass at the inner cylinder wall and is generated by an electric or electromagnetic field; or the action of ozone on the glass surface. The glass with the lowered contact angle is contacted with water to form a water film on the contacted glass.

Abstract: Pharmaceutical containers and methods for producing, registration, identification and authentication of such containers and for determining the operation state of machines for producing pharmaceutical containers are provided.

Abstract: A positioning device for a preloading ring of a hot forming machine is provided. The device has a first holding element and a second holding element. The first holding element has a first recess and a second recess. The second recess is at a distance radially with respect the first recess. The second holding element is arranged in a region of and faces the first and second recess. The first and second holding elements are configured and arranged movably about respective axes with respect to each other so that movement towards each other encloses a glass tube in each of the first and second recesses and between the holding elements.

Abstract: A holding structure for simultaneously holding containers for pharmaceutical, medical, or cosmetic compositions, includes: at least 10 receptacles for receiving the containers and being formed by side walls; a flat base frame including a central recess; first webs running parallel to each other in a first direction across the central recess; second webs running parallel to each other in a second direction across the central recess, the first webs and the second webs being arranged such that the first webs and the second webs form the side walls, each of the first webs and the second webs being formed as a continuous beam having a maximum waviness wmax of 4.0 mm; and a support structure connected with the first webs and the second webs and being formed as an outer frame or a plurality of stabilizing ribs in a grid pattern.

Abstract: A charge device is provided that includes a charge barrel having a charge. The charge barrel has an exit aperture and a flexible positioning device at the exit aperture. The charge is located inside the charge barrel. The charge barrel is adapted and arranged so that the charge is able to exit the charge barrel via the exit aperture.

Abstract: An arrangement includes a holding device for primary packaging containers including: a first component including first receptacles and spanning a first component plane; and a second component including second receptacles and spanning a second component plane. The first component and the second component superimpose one another such that each primary packaging container can be detachably accommodated in one of the first receptacles and the second receptacles such that the first component and the second component together restrict movement of the primary packaging container in one of the component planes and in a direction which is perpendicular to one of the component planes. For each of the first receptacles, there is one of the second receptacles which has a minimum distance from the first receptacle and, for each of the first receptacles, the minimum distance is predetermined by the second component, a third component of the holding device, or both.

Abstract: A method for molding end portions on glass containers that store pharmaceutical active ingredients is provided. The glass containers are produced from a glass tube by hot-forming, an end portion having a neck opening using a centrally disposed opening forming tool interacting with a shaping tool at one end of the glass containers. In the method, dimensional data is provided for the respective glass tube and the position of the shaping tool is adjusted in a motorized manner in the axial direction (z) of the glass containers so as to correspond to the provided dimensional data for the respective glass tube.

Abstract: Container assemblies for accommodating pharmaceutical compositions are provided. The container assembly includes a container and a plunger. The container has a hollow cylindrical body with an open end and a closed end, which is closed by a bottom portion. The hollow cylindrical body has a length (L), an outer diameter (DO), and an inner diameter with a length to outer diameter ratio between 3:1 and 15:1. The hollow cylindrical body and the bottom portion are formed integrally and of the same material, which is a glass or polymer material. The container has an inner surface with an average Zn-leachability of 0.00085 ?g/cm2 or less. The plunger is inside the hollow cylindrical body at the open end, is pierceable by a cannula, and is slidable relative to the hollow cylindrical body from the open end towards the closed end.

Abstract: A process for preparing a glass container that includes: providing a glass tube with a first portion, a second portion, and a longitudinal axis (Ltube); holding the first portion in a first clamping chuck and the second portion in a second clamping chuck; rotating the glass tube around the longitudinal axis (Ltube); heating, via a heater, the glass tube above a glass transition temperature; separating the first and second portions from one another by pulling apart along the longitudinal axis (Ltube) while the heated glass tube is still rotating by moving the first and the second chucks away from each other; and moving the heater, while moving the first and second chucks away from each other, so that the heater follows a mass that remains at a circular end region of the first and/or second portion.

Abstract: A transport device for medical containers includes a carrier plate which has openings for receiving medical containers, and optionally a trough-shaped container which is formed such that the carrier plate can be inserted in the trough-shaped container. The carrier plate contains a polymer and 7.5 to 50 wt.-% inorganic particles. The optional trough-shaped container contains a polymer and optionally 7.5 to 50 wt.-% inorganic particles.