Patents Assigned to Schwabe GmbH
  • Patent number: 5399348
    Abstract: The invention relates to an improved extract from Ginkgo biloba leaves, a method of preparation of the same and pharmaceuticals containing the extract.
    Type: Grant
    Filed: June 24, 1992
    Date of Patent: March 21, 1995
    Assignee: Dr. Willmar Schwabe GmbH & Co.
    Inventor: Klaus-Peter Schwabe
  • Patent number: 5322688
    Abstract: The invention relates to a method of preparation of an improved extract from Ginkgo biloba leaves and to pharmaceuticals containing the extract.
    Type: Grant
    Filed: June 15, 1992
    Date of Patent: June 21, 1994
    Assignee: Dr. Willmar Schwabe GmbH & Co.
    Inventor: Klaus-Peter Schwabe
  • Patent number: 5320547
    Abstract: To permit easy insertion and removal of a compact fluorescent lamp (2) in and from a socket, the socket is formed with a body (3) having an engagement surface wall (5) from which a shelf (4) projects bounded by side walls (22, 23) to define a base reception cavity (25). The engagement wall (5) is formed with slits (11) to permit terminal pins (13) from the lamp to pass therethrough, for engagement with electrical terminal contacts (T). The lamp is held in position by a resilient catch or latch or snap-over element (14) movably mounted on the engagement wall (5), for example by being molded on a separated strip portion (15) forming a resilient holder, and projecting from the engagement wall (5), to snap over the end portion of a base (35) of the lamp, when inserted. To release the lamp, the catch can be bent backwardly. Holding projections (30) on the shelf lock the lamp in position.
    Type: Grant
    Filed: May 6, 1993
    Date of Patent: June 14, 1994
    Assignee: Vossloh-Schwabe GmbH
    Inventors: Hans-Peter Mews, Peter Morlinghaus
  • Patent number: 5296224
    Abstract: Dry extract from kava-kava drug having a total content of kava lactones of at least 50% by weight and a flavokawin content of at the most 0.3% by weight. The extract is distinguished by good water solubility and high bioavailability after oral administration. To increase the kava lactone content in the extract and decrease the flavokawin content, a process is proposed in which the raw extract is brought into solution and the content of flavokawins diminished by cold precipitation or by solvent distribution, whereafter the solution is concentrated to dryness. Drugs are made using the dry extract.
    Type: Grant
    Filed: May 7, 1992
    Date of Patent: March 22, 1994
    Assignee: Dr. Wilmar Schwabe GmbH & Co.
    Inventor: Klaus-Peter Schwabe
  • Patent number: 4965283
    Abstract: Novel esters of amino acids are proposed of which the alcoholic components are formed from threo-4-alkoxy-5-arylhydroxymethyl-2(5H)-furanones. These esters may be present in the form of racemates, pure diastereomers or enantiomers or in the form of diastereomer or enantiomer mixtures. The compounds are anticonvulsive and antiepileptic and due to their good water solubility are easier to administer and more readily absorbable than known anti-convulsives and antiepileptics. A novel process is also disclosed which leads stereoselectively to the diastereomers or the enantiomers or mixtures thereof. The invention further relates to the use of the novel amino acid esters as pharmaceutical preparations and in the production of pharmaceutical preparations.
    Type: Grant
    Filed: June 28, 1989
    Date of Patent: October 23, 1990
    Assignee: Dr. Willmar Schwabe GmbH & Co.
    Inventors: Klaus Klessing, Shyam S. Chatterjee
  • Patent number: 4909379
    Abstract: A vibrator conveyor system, for example in the form of a circular or linear conveyor, has a reciprocating plate adapted for carrying a container, and electromagnetic oscillating armature motors for moving said plate along a primary advancement direction or vector; each motor has a stationary stator, an armature secured to the reciprocating plate, and an excitation coil driven by alternating current or pulsating direct current, the coil being disposed on a pole piece the stator, the pile piece having a stator pole surface cooperating with an armature pole surface. The reciprocating plate is elastically supported by spring elements in a manner limiting its vertical and horizontal motion. The elongated spring elements are aligned along at least a portion of the rim of the plate with equal inclination with respect to a plane containing the conveyor advancement vector, and are fastened to the plate.
    Type: Grant
    Filed: April 20, 1988
    Date of Patent: March 20, 1990
    Assignee: Schwabe GmbH
    Inventors: Bernhard Albeck, Klaus Albrecht
  • Patent number: 4892883
    Abstract: Medicaments containing bilobalide which can be used to control nervous diseases are described.
    Type: Grant
    Filed: October 11, 1988
    Date of Patent: January 9, 1990
    Assignee: Willman - Schwabe GmbH & Co.
    Inventors: Shyam S. Chatterjee, Benard L. Gabard, Hermann E. W. Jaggy
  • Patent number: 4855320
    Abstract: The present invention provides 5-arylalkyl-4-alkoxy-2(5H)-furanones of the formula: ##STR1## wherein the oxygen atoms on C-5 and C-.alpha., relative to one another, are in the threo-position, with the exclusion of those compounds of the formula (I) wherein R.sup.2 is H or CH.sub.3 when n=0 or 2, R.sup.o =H, R.sup.1 =CH.sub.3, R.sup.3 =H and R.sup.4 =H.The present invention also provides processes for their preparation, as well as new 3-alkoxy-5-(subst.)-phenyl-2(E), 4(E)-pentadienoates as reactive intermediates for the preparation of the new furanone derivatives.The new furanone derivatives of the threo series are active as anticonvulsives/anti-epileptics. Therefore, the present invention also provides medicaments which contain these new furanone derivatives, as well as known furanones, the anticonvulsive/anti-epileptic effectiveness of which has been found for the first time.
    Type: Grant
    Filed: May 4, 1987
    Date of Patent: August 8, 1989
    Assignee: Dr. Willmar Schwabe GmbH & Company
    Inventors: Shyam S. Chatterjee, Klaus Klessing
  • Patent number: 4711019
    Abstract: In a method for making U-shaped core laminations and T-shaped magnetic circuit closing elements fitting in between the legs thereof, in a choke, ballast or transformer, in particular for use as an accessory element in gas discharge lamps, two mutually offset rows of U-shaped core laminations having their open ends facing one another and having the pairs of adjacent outer legs thereof interfitting with one another are punched out in such a manner that one pair of outer legs of one row is laterally adjacent to one pair of outer legs of the other row, and the T-shaped magnetic circuit closing elements, with cross legs adjacent to the connecting middle legs of the U-shaped core lamination are punched out of the free spaces located between the ends of the pairs of outer legs and the connecting legs, located facing tem and spaced apart from them, of the U-shaped core laminations.
    Type: Grant
    Filed: March 18, 1986
    Date of Patent: December 8, 1987
    Assignee: Schwabe GmbH
    Inventors: Bernhard Albeck, Siegfried Goedicke
  • Patent number: 4622324
    Abstract: 1.4;3.6-Dianhydrohexitol nitrates substituted by purine bases, namely, adenyl-desoxy-1.4;3.6-dianhydrohexitol nitrates of the general formula Ia as well as theophyllinyl-desoxy-1.4;3.6-dianhydrohexitol nitrates of the general formula Ib, ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and, independently of one another signify(a) a hydrogen atom,(b) a straight-chained or branched alkyl group with 1 to 7 C-atoms,(c) an .omega.-phenylalkyl group, whereby the alkyl group has 1 to 7 C-atoms and whereby the phenyl ring can be halogen-substituted in the p-position, or wherein(d) R.sup.1 signifies one of the residues given under (a) to (c) and R.sup.2 an acyl radical or an aliphatic, possibly methyl-substituted monocarboxylic acid with 2 to 7 C-atoms, or wherein(e) R.sup.1 and R.sup.
    Type: Grant
    Filed: August 17, 1984
    Date of Patent: November 11, 1986
    Assignee: Dr. Willmar Schwabe GmbH & Co.
    Inventors: Klaus Klessing, Shyam S. Chatterjee
  • Patent number: 4571407
    Abstract: Medicaments containing bilobalid which can be used to control nervous diseases are described.
    Type: Grant
    Filed: October 19, 1984
    Date of Patent: February 18, 1986
    Assignee: Dr. Willmar Schwabe GmbH & Co.
    Inventors: Shyam S. Chatterjee, Bernard L. Gabard, Hermann E. W. Jaggy
  • Patent number: 4542137
    Abstract: Alkylaminodesoxy-1.4;3.6-dianhydrohexitol nitrates substituted by purine bases of the general formula I, ##STR1## wherein R.sup.1 signifies a hydrogen atom or a lower alkyl group with 1 to 4 C-atoms, X a straight-chained or branched alkyl or hydroxyalkyl group with 1 to 7 C-atoms, Y a 1,3-dialkylxanthin-7-yl or a 3,7-dialkylxanthin-1-yl group, each with straight or branched-chained alkyl groups with 1 to 5 C-atoms, or an adenin-9-yl group, as well as their physiologically acceptable acid-addition salts. Process for the preparation of said compounds and pharmaceutical compositions containing said compounds.
    Type: Grant
    Filed: July 20, 1981
    Date of Patent: September 17, 1985
    Assignee: Dr. Willmar Schwabe GmbH & Co.
    Inventors: Klaus Klessing, Shyam S. Chatterjee
  • Patent number: 4535158
    Abstract: Aminodesoxy-1.4;3.6-dianhydrohexitol derivatives of the general formula I, ##STR1## wherein R.sup.1 and R.sup.2 in each case independently of one another, signifies a hydrogen atom or a lower alkyl group with 1 to 4 C-atoms or wherein R.sup.1 signifies a hydrogen atom and R.sup.2 an adamant(1)yl radical or wherein R.sup.1 , and R.sup.2, together with the nitrogen atom to which they are attached, (a) signify the residue of a cyclic, non-aromatic secondary amine possibly containing a further hetero atom or (b) the aden(9)yl radical possibly mono- or disubstituted on the 6-amino group or (c) the 6-alkylmercaptopurin(9)yl radical or (d) the theophyllin-(7)yl radical or (e) the 6-chloropurin-9-yl radical or wherein R.sup.1 signifies a hydrogen atom or a lower alkyl group with 1 to 4 C-atoms and R.sup.2 an .omega.-theophyllin(7)ylalkyl radical or an .omega.-theobromin-1-ylalkyl radical or an .omega.
    Type: Grant
    Filed: September 19, 1983
    Date of Patent: August 13, 1985
    Assignee: Dr. Willmar Schwabe GmbH & Co.
    Inventor: Klaus Klessing
  • Patent number: 4528289
    Abstract: The present invention provides corynantheine derivatives of the general formula: ##STR1## wherein R is a hydrogen or alkali metal atom, an ammonium group or the residue of an amine or an alkyl radical containing up to 4 carbon atoms; and the physiologically acceptable acid-addition salts thereof.The present invention also provides processes for the preparation of these corynantheine derivatives and pharmaceutical compositions containing them. Furthermore, the present invention is concerned with the use of dihydrocorynantheine as an antihypertonic.
    Type: Grant
    Filed: January 28, 1983
    Date of Patent: July 9, 1985
    Assignee: Dr. Willmar Schwabe GmbH & Co.
    Inventors: Hermann E. W. Jaggy, Shyam S. Chatterjee, Bernard L. Gabard
  • Patent number: 4479951
    Abstract: 1.4;3.6-Dianhydrohexitol nitrates substituted by purine bases, namely, adenyl-desoxy-1.4;3.6-dianhydrohexitol nitrates of the general formula Ia as well as theophyllinyl-desoxy-1.4;3.6-dianhydrohexitol nitrates of the general formula Ib, ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and, independently of one another signify(a) a hydrogen atom,(b) a straight-chained or branched alkyl group with 1 to 7 C-atoms,(c) an .omega.-phenylalkyl group, whereby the alkyl group has 1 to 7 C-atoms and whereby the phenyl ring can be halogen-substituted in the p-position, or wherein(d) R.sup.1 signifies one of the residues given under (a) to (c) and R.sup.2 an acyl radical or an aliphatic, possibly methyl-substituted monocarboxylic acid with 2 to 7 C-atoms, or wherein(e) R.sup.1 and R.sup.
    Type: Grant
    Filed: July 20, 1981
    Date of Patent: October 30, 1984
    Assignee: Dr. Willmar Schwabe GmbH & Co.
    Inventors: Klaus Klessing, Shyam S. Chatterjee
  • Patent number: 4413122
    Abstract: Aminodesoxy-1.4;3.6-dianhydrohexitol derivatives of the general formula I, ##STR1## wherein R.sup.1 and R.sup.2, in each case independently of one another, signifies a hydrogen atom or a lower alkyl group with 1 to 4 C-atoms or wherein R.sup.1 signifies a hydrogen atom and R.sup.2 an adamant(1)yl radical or wherein R.sup.1 and R.sup.2, together with the nitrogen atom to which they are attached, (a) signify the residue of a cyclic, non-aromatic secondary amine possibly containing a further hetero atom or (b) the aden(9)yl radical possibly mono- or disubstituted on the 6-amino group or (c) the 6-alkylmercaptopurin(9)yl radical or (d) the theophyllin(7)yl radical or (e) the 6-chloropurin-9-yl radical or wherein R.sup.1 signifies a hydrogen atom or a lower alkyl group with 1 to 4 C-atoms and R.sup.2 an .omega.-theophyllin(7)ylalkyl radical or an .omega.-theobromin-1-ylalkyl radical or an .omega.
    Type: Grant
    Filed: July 20, 1981
    Date of Patent: November 1, 1983
    Assignee: Fa. Wilmar Schwabe GmbH & Co.
    Inventor: Klaus Klessing
  • Patent number: 4401825
    Abstract: Reactive iridoid derivates represented by the following general formula ##STR1## (wherein R represents a hydrogen atom, an alkyl group with 1 to 5 carbon atoms, an acyl group with 2 to 6 C atoms, an unsubstituted aralkyl group with 7 to 12 C atoms, a methanesulfonyl- or toluenesulfonyl group, a benzoyl-, a preferably para-substituted nitrobenzoyl- or chlorobenzoyl group, or a tetrahydropyranyl group), process for the manufacture of said derivatives starting from catapol as an easily obtainable natural substance and use of said derivatives as intermediates for the manufacture of prostanoids.
    Type: Grant
    Filed: July 23, 1981
    Date of Patent: August 30, 1983
    Assignee: Willmar Schwabe GmbH & Co.
    Inventors: Klaus Weinges, Herbert von der Eltz, Hermann Jaggy