Patents Assigned to Science Applications International Coporation Saic
  • ISOINDOLINE COMPOUNDS FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY AND OTHER USES
    Publication number: 20100267712
    Abstract: Disclosed is a compound of Formula (I) in which W and R1-R6 are defined herein. Also disclosed is a method of treating spinal muscular atrophy, as well as methods of using such compounds to increase SMN expression, increase EAAT2 expression, or increase the expression of a nucleic acid that encodes a translational stop codon introduced directly or indirectly by mutation or frameshift.
    Type: Application
    Filed: September 26, 2008
    Publication date: October 21, 2010
    Applicants: Human Services, Science Applications International Coporation Saic, Albany Molecular Research, Inc.,
    Inventors: Jill E. Heemskerk, John M. McCall, Keith D. Barnes