Patents Assigned to Science Union et Cie, Societe Francaise de Recherche Medicale
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Patent number: 4264613Abstract: Piperidylbenzimidazolinone compounds of the formula: ##STR1## in which: R is hydrogen, hydroxy, hydroxymethyl, methoxycarbonyl, formamido, acetamido, mesylamino, oxalamino, ethoxalylamino, carbamoyl ##STR2## ureido ##STR3## or sulfamoylamino ##STR4## in which R' and R" are hydrogen or lower alkyl, T is hydrogen, halogen, lower alkyl or lower alkoxy, andZ is hydrogen, lower alkyl or lower alkenyl each in straight or branched chain.These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of autoimmune, allergic and inflammatory diseases and in the treatment of respiratory insufficiency of asthma.Type: GrantFiled: August 1, 1979Date of Patent: April 28, 1981Assignee: Science Union et cie, Societe Francaise de Recherche MedicaleInventors: Gilbert Regnier, Alain Dhainaut, Jacques Duhault, Michelle Boulanger
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Patent number: 4259335Abstract: 1-methyl-4-piperidinol esters of the formula: ##STR1## in which R is 7-chloro-4-quinolyl, 7-trifluoromethyl-4-quinolyl or 8-trifluoromethyl-4-quinolyl.These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of inflammatory processes and painful syndroms.Type: GrantFiled: August 6, 1979Date of Patent: March 31, 1981Assignee: Science Union et Cie, Societe Francaise de Recherche MedicaleInventors: Laszlo Beregi, Pierre Hugon, Jacques Bure, Francoise Degrand
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Patent number: 4195076Abstract: This application relates to a process for producing two glycoproteins of viral origin. More specifically, it relates to a process for producing in a substantially pure form Neuraminidase and Hemagglutinin from the cultures of Myxovirus Influenzae. These glycoproteins find a therapeutical use as a mean for preventing or treating the flu.Type: GrantFiled: September 25, 1978Date of Patent: March 25, 1980Assignee: Science Union et Cie, Societe Francaise de Recherche MedicaleInventor: Robert Fontanges
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Patent number: 4161529Abstract: Pyrrolidone derivatives of the formula: ##STR1## wherein R is hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl,AndY is hydrogen, saturated or unsaturated hydrocarbon radical up to C.sub.4, hydroxyethyl, hydroxypropyl or carboxymethyl.These compounds are used as medicines especially in the treatment of lipid-metabolism disorders.Type: GrantFiled: February 14, 1978Date of Patent: July 17, 1979Assignee: Science Union et Cie, Societe Francaise de Recherche MedicaleInventors: Laszlo Beregi, Pierre Hugon, Jacques Duhault, Michelle Boulanger
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Patent number: 4154851Abstract: This invention relates to novel .omega.-benzylamino alkanoic acids, to their salts with an organic or mineral base or with an organic or mineral acid. These alkanoic acids may be in a racemic form or resolved into their optically-active enantiomers.They are produced by condensing an oxoalkanoic acid with a benzylamine under reducing conditions.This invention also relates to .omega.-benzylamino alkanoic amides and to .omega.-benzylamino alkanoic acid esters.They have therapeutical use, namely in the psychotherapeutical field. They are utilized in the form of pharmaceutical compositions.Type: GrantFiled: March 11, 1977Date of Patent: May 15, 1979Assignee: Science Union et Cie, Societe Francaise de Recherche MedicaleInventors: Charles Malen, Pierre Roger, Jean-Claude Poignant
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Patent number: 4136168Abstract: This application relates to a process for producing two glycoproteins of viral origin. More specifically, it relates to a process for producing in a substantially pure form Neuraminidase and Hemagglutinin from the cultures of Myxovirus Influenzae. These glycoproteins find a therapeutical use as a means for preventing or treating the flu.Type: GrantFiled: February 26, 1975Date of Patent: January 23, 1979Assignee: Science Union et Cie, Societe Francaise de Recherche MedicaleInventor: Robert Fontanges
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Patent number: 4123531Abstract: This invention relates to novel acetamides, the nitrogen of which is substituted with an amino lower alkyl chain.This invention also relates to a process for producing the said N-substituted acetamides.The end compounds have therapeutical utility and find a use as anti-convulsant agents.Type: GrantFiled: November 26, 1976Date of Patent: October 31, 1978Assignee: Science Union et Cie, Societe Francaise de Recherche MedicaleInventors: Michel Vincent, Georges Remond, Michel Laubie, Jean-Claude Poignant
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Patent number: 4102890Abstract: Cyclopropylmethylamines which are substituted on the 2-position of nitrogen heterocycles so as to provide new compounds of the formula ##STR1## wherein A is oxygen, sulfur, or nitrogen; the other "R" variables in general are hydrogen, lower-alkyl, cyclopropyl, or lower-alkyl substituted cyclopropyl; and the n's are the numbers 0 to 3, inclusive, and acid addition salts thereof, are disclosed. The compounds are cardiovascular agents, which are depressive of the central nervous system. Their effects include hypnosis, analgesia, and neuro-modulation. They can be used as anti-hypertensive agents.Type: GrantFiled: August 11, 1976Date of Patent: July 25, 1978Assignee: Science-Union et Cie, Societe Francaise de Recherche MedicaleInventors: Charles Malen, Monique Desnos, Michel Laubie, Jean-Claude Poignant
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Patent number: 4092423Abstract: This invention relates to ortho-alkoxy anilines having the amino group substituted with an amino lower alkyl carboxylic residue, as well as their physiologically-compatible acid-addition salts and their optically-active isomers.This invention also relates to processes for making the same in which an ortho-alkoxy aniline is reacted with a lower alkanoic acid or a functional derivative thereof.The compounds of the invention have therapeutical utility namely for the prevention or treatment of digestive disorders and gastric ulcers.Type: GrantFiled: September 16, 1976Date of Patent: May 30, 1978Assignee: Science Union et Cie., Societe Francaise de Recherche MedicaleInventors: Charles Malen, Pierre Roger, Jean-Claude Poignant, Xavier Pascaud
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Patent number: 4086355Abstract: The invention relates to novel spirodecane derivatives and more specifically to novel azaspirodecane diones.The invention also provides process for producing said azaspirodecane diones which consists mainly in cyclizing a disubstituted glutaronitrile or a glutaric acid in the presence of an amino compound.The compounds of the present invention have interesting pharmacological properties and they find therapeutical uses.Type: GrantFiled: January 19, 1976Date of Patent: April 25, 1978Assignee: Science Union et Cie., Societe Francaise de Recherche MedicaleInventors: Michel Vincent, Georges Remond, Jean-Claude Poignant
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Patent number: 4080452Abstract: This invention relates to novel N-acyl anilines, to a process for their preparation and to pharmaceutical compositions containing them. The N-acyl anilines are obtained by condensing a substituted aniline with an aminolower alkyl carboxylic acid or a functional derivative thereof.The compounds of the invention have therapeutic utility namely in the gastro-enterologic field.Type: GrantFiled: February 9, 1976Date of Patent: March 21, 1978Assignee: Science Union et Cie, Societe Francaise de Recherche MedicaleInventors: Charles Malen, Pierre Roger, Xavier Pascaud
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Patent number: 4071629Abstract: This invention relates to pharmaceutical compositions having psychoanaleptic activity containing a thiamine disulphide derivative as active ingredient.The novel pharmaceutical composition has therapeutical utility, namely, in the treatment of psychic and/or behavioral disturbances due to psychasthenia.Type: GrantFiled: August 27, 1976Date of Patent: January 31, 1978Assignee: Science Union et Cie, Societe Francaise de Recherche MedicaleInventor: Jacques Servier
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Patent number: 4066662Abstract: Disubstituted azabicycloalkanes of the formula ##STR1## wherein: N IS 0, 1 OR 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.Type: GrantFiled: December 30, 1976Date of Patent: January 3, 1978Assignee: Science Union et Cie., Societe Francaise de Recherche MedicaleInventors: Laszlo Beregi, Pierre Hugon, Xavier Pascaud, Jean-Claude Poignant
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Patent number: 4064245Abstract: Phenoxy compounds of the formula: ##STR1## wherein R and R', which are the same or different, are hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, trifluoromethyl, trifluoromethylthio, trifluoromethoxy, lower alkoxy-carbonyl or dimethylsulfamoyl.These compounds are used as medicines especially in the treatment of glucid -- and lipid -- metabolism disorders.Type: GrantFiled: July 14, 1976Date of Patent: December 20, 1977Assignee: Science Union et Cie, Societe Francaise de Recherche MedicaleInventors: Laszlo Beregi, Pierre Hugon, Jacques Duhault, Michelle Boulanger
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Patent number: 4059621Abstract: This invention relates to propanol derivatives and to a process for their preparation.Type: GrantFiled: July 16, 1973Date of Patent: November 22, 1977Assignee: Science Union et Cie, Societe Francaise de Recherche MedicaleInventors: Michel Vincent, Georges Remond, Michel Laubie
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Patent number: 4056623Abstract: Pharmaceutical compositions containing a compound selected from N-phenyl sulphonyl-N'-(3-azabicycloalkyl) ureas or physiologically acceptable salts thereof and an appropriate pharmaceutical carrier for reducing the risk of arteriosclerosis.Type: GrantFiled: June 3, 1976Date of Patent: November 1, 1977Assignee: Science Union et Cie, Societe Francaise de Recherche MedicaleInventor: Jacques Duhault
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Patent number: 4042598Abstract: Disubstituted azabicycloalkanes of the formula ##STR1## wherein: N IS 0, 1 OR 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.Type: GrantFiled: May 13, 1976Date of Patent: August 16, 1977Assignee: Science Union et Cie, Societe Francaise de Recherche MedicaleInventors: Laszlo Beregi, Pierre Hugon, Xavier Pascaud, Jean-Claude Poignant