Abstract: A metal nanolaminate includes a plurality of units stacked in a longitudinal direction of the metal nanolaminate. Each of the units includes a first layer and a second layer stacked in the longitudinal direction. The first layer includes a first metal material formed of a first metallic element and the second layer includes the first metal material and a second metal material formed of a second metallic element. Each of the first layer and the second layer has a thickness of at least 5 nm but less than 100 nm in the longitudinal direction.

Abstract: The present invention relates to a crystalline form of N-(3-fluoro-4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide p-toluenesulfonate, the process for preparing the crystalline form thereof, and the pharmaceutical compositions comprising the crystalline form thereof. This invention also relates to a method of using such a crystalline form and pharmaceutical compositions comprising the crystalline form thereof in the treatment of hyperproliferative diseases in mammals, especially in humans.

Abstract: The object of the present invention is to provide a water/oil-repellent coating composition for forming a film capable of attaining both water/oil repellency and abrasion resistance. The water/oil-repellent coating composition comprises: an organosilicon compound (A) and a metal compound (B), wherein at least one first hydrocarbon chain-containing group and at least one hydrolyzable group are bonded to a silicon atom in the organosilicon compound (A), where in at least one hydrolyzable group is bonded to a metal atom in the metal compound (B), wherein a second hydrocarbon chain-containing group having a length shorter than the length of the first hydrocarbon chain-containing group may be bonded to the metal atom in the metal compound (B), and wherein a molar ratio of the metal compound B) to the organosilicon compound (A) as metal compound (B)/organosilicon compound (A) is not less than 18 and not more than 48.

Abstract: The invention provides a novel integrated structure and system-based approach for drug target prediction that enables the large-scale discovery of new targets for existing drugs Novel computer-readable storage media and computer systems are also provided. Methods and systems of the invention use novel sequence order-independent structure alignment, hierarchical clustering, and probabilistic sequence similarity techniques to construct a probabilistic pocket ensemble (PPE) that captures even promiscuous structural features of different binding sites for a drug on known targets. The drug's PPE is combined with an approximation of the drug delivery profile to facilitate large-scale prediction of novel drug-protein interactions with several applications to biological research and drug development.

Abstract: A high-strength and ultra heat-resistant high entropy alloy (HEA) matrix composite material and a method of preparing the HEA matrix composite material are provided. The HEA matrix composite material may include at least four matrix elements among Co, Cr, Fe, Ni, Mn, Cu, Mo, V, Nb, Ta, Ti, Zr, W, Si, Hf and Al, and a body-centered cubic (BCC) forming alloy element.

Abstract: The present invention relates to a new isolated polypeptide comprising an amino acid sequence having at least 94%, 95%, 99% or 100% identity to the full length amino acid sequence set forth in SEQ ID NO: 1, and having a polyester degrading activity, and uses thereof.

Abstract: The object of the present invention is to attain both water/oil repellency and hardness. The transparent film of the present invention comprises: a polysiloxane backbone; and a first hydrocarbon chain-containing group bonded to a part of silicon atoms forcing the polysiloxane backbone, wherein the thickness of the transparent film is not less than 6 nm and not more than 50 nm.

Abstract: According to the hydrogen peroxide plasma ionization generator device having a double-jet nozzle suggested by the present invention, the double jet nozzle forming an air passage is configured to construct the hydrogen peroxide plasma ionization generator device such that the hydrogen peroxide and ion particles are sprayed finer than that of a conventional single-jet nozzle.

Abstract: Anti-PD-1 antibodies are disclosed. Also disclosed are pharmaceutical compositions comprising such antibodies, and uses and methods using the same.

Abstract: According to various embodiments, there is provided an optical device including a first waveguide configured to guide a light wave along a longitudinal axis; a first grating at least partially formed in the first waveguide, the first grating arranged away from the longitudinal axis in a first direction; and a second grating at least partially formed in the first waveguide, the second grating arranged away from the longitudinal axis in a second direction; wherein the second direction is different from the first direction.

Abstract: A superconducting bulk magnet comprising a plurality of superconducting bulk materials combined, in which breakage of superconducting bulk materials is prevented and a strong magnetic field can be generated, that is, a superconducting bulk magnet comprising a plurality of superconducting bulk materials, each comprising a single-crystal formed RE1Ba2Cu3Oy (RE is one or more elements selected from Y or rare earth elements, where 6.8?y?7.

Abstract: A nickel lithium ion battery positive electrode material having a concentration gradient, and a preparation method therefor. The material is a core-shell material having a concentration gradient, the core material is a material having a high content of nickel, and the shell material is a ternary material having a low content of nickel. The method comprises: synthesizing a material precursor having a high content of nickel by means of co-precipitation, co-precipitating a ternary material solution having a low content of nickel outside the material precursor having a high content of nickel, aging, washing, and drying to form a composite precursor in which the low nickel material coats the high nickel material, adding a lithium source, grinding, mixing, calcining, and cooling to prepare a high nickel lithium ion battery positive electrode material.

Abstract: Provided is a vanadium oxide film which shows substantially no hysteresis of resistivity changes due to temperature rising/falling, has a low resistivity at room temperature, has a large absolute value of the temperature coefficient of resistance, and shows semiconductor-like resistance changes in a wide temperature range. In the vanadium oxide film, a portion of the vanadium has been replaced by aluminum and copper, and the amount of substance of aluminum is 10 mol % based on the sum total of the amount of substance of vanadium, the amount of substance of aluminum, and the amount of substance of copper. This vanadium oxide film has a low resistivity, has a large absolute value of the temperature coefficient of resistance, and shows substantially no hysteresis of resistivity changes due to temperature rising/falling.

Abstract: A method for manufacturing a charge pump-based artificial lightning generator comprises the steps of: forming a second electrode on a prepared substrate; forming a negatively charged body having a sponge structure under the second electrode; removing spherical polymer particles from the negatively charged body using a toluene solution; allowing metal particles to penetrate into the negatively charged body; forming a positively charged body in a location which is at a predetermined distance below the negatively charged body in order to generate charges; nano-structuring the surface of the positively charged body; coating the nano-structured surface of the positively charged body with second metal particles; forming a ground layer for charge separation while maintaining a constant distance in the downward direction from one side of the positively charged body; and forming a first electrode for charge accumulation in a location which is at a predetermined distance below the positively charged body.

Abstract: Disclosed is an antibiotic aqueous dispersion composition including as an active ingredient zinc pyrithione and, at least one subsidiary antiseptic selected from the group consisting of thiamine dilauryl sulphate (TDS), a salt and glyceryl monoalkyl ether. The composition has excellent stability and wide antibiotic or antiseptic spectra to bacteria and fungus.

Abstract: The present invention generally relates to the transdermal delivery of various compounds. In some aspects, transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising a phosphodiesterase type 5 inhibitor and/or a salt thereof, and optionally, a hostile biophysical environment and/or a nitric oxide donor. In some cases, the composition may be stabilized using a combination of a stabilization polymer (such as xanthan gum, KELTROL® BT and/or KELTROL® RD), propylene glycol, and a polysorbate surfactant such as Polysorbate 20, which combination unexpectedly provides temperature stability to the composition, e.g., at elevated temperatures such as at least 40° C. (at least about 104° F.), as compared to compositions lacking one or more of these.

Abstract: A downlight is provided. The downlight includes an insulating housing, a power supply assembly, a reflection cup, a LED light source, and a diffusion cover, wherein, the interior of the insulated housing is divided into a first cavity and a second cavity, the power supply assembly is arranged in the first cavity, the reflection cup is arranged in the second cavity, the LED light source is arranged in the reflection cup and connected with the power supply assembly, the reflection cup is configured to dissipate the heat of the LED light source and reflect the light from it to the open end of the second cavity, and the diffusion cover encapsulated in the open end of the second cavity is configured to diffuse the light.

Abstract: This invention relates to a new and distinct everbearing variety of raspberry plant named ‘PS-06.024-27’. The new variety is primarily adapted to the growing conditions of the central coast of California and is characterized by the following: mid-season primocane production with medium sized fruit of medium red coloration and medium gloss. Fruit is of consistent conic shape, weak adherence of receptacle and is of good flavor. Foliage is strongly concave, medium green; possessing weak rugosity and always 3 foliates. Primocanes have a strong waxy coat, medium thorn density and weak to medium anthocyanin coloration.

Abstract: A method for preparing a fermented drink is described. The method comprises the initiation of fermentation by inoculating the fermentable drink with fermentative bacteria in the form of biofilm.

Abstract: A semiconductor device having a channel region that is formed in a germanium layer and has a first conductive type, and a source region and a drain region that are formed in the germanium layer and have a second conductive type different from the first conductive type, wherein an oxygen concentration in the channel region is less than an oxygen concentration in a junction interface between at least one of the source region and the drain region and a region that surrounds the at least one of the source region and the drain region and has the first conductive type.