Abstract: A method may include obtaining fracture image data regarding a geological region of interest. The method may further include determining various fractures in the fracture image data using a first artificial neural network and a pixel-searching process. The method may further include determining a fracture model using the fractures, a second artificial neural network, and borehole image data. The method may further include determining various fracture permeability values using the fracture model and a third artificial neural network. The method may further include determining various matrix permeability values for the geological region of interest using core sample data. The method may further include generating a coarsened grid model for the geological region of interest using a fourth artificial neural network, the matrix permeability values, and the fracture permeability values.

Abstract: Disclosed are a method for increasing the viability of cells by ultrasound irradiation and an ultrasound irradiation apparatus using same. The method comprises: applying a drug and an epidermal drug delivery system onto the epidermis of a subject; and, with ultrasound parameters each being preset within a certain range, an ultrasound irradiation apparatus irradiating ultrasound onto the epidermis of the subject through an ultrasound generation unit placed within a critical range from the epidermis of the subject, wherein the epidermal drug delivery system induces the formation of cavities, i.e., cavitation around the epidermis of the subject when the ultrasound is irradiated, the ultrasound parameters at least include an ultrasound pressure and an ultrasound duty percentage, the ultrasound pressure is 0.5-1 MPa, and the ultrasound duty percentage is 1-5%.

Abstract: A method for analyzing signal irregularity of radiation in a lightning leader is provided, which relates to a field of lightning signal processing and includes: S1: acquiring electric field signals; S2: dividing the electric field signals into multiple segments according to time, and calculating an average sample entropy value of each segment of the electric field signals; S3: dividing the multiple segments of electric field signals into three regions according to the time, quantifying irregularity of radiation of the three regions in the leader according to sample entropies and performing classification based on numerical variation characteristics of the irregularity; S4: comparing the classified data with lightning positioning data to form an analysis database; and S5: acquiring real-time electric field signals, calculating average sample entropy values of the electric field signals, and predicting development characteristics of irregular radiation in the lightning leader.

Abstract: Provided herein are compositions and methods for the identification of an expression profile in a single cell or population of cells. Kits for use with the disclosed methods are also provided, including antibodies, with a unique molecular identifier and antibody identifier, and primers for amplification of the antibody identifier sequence.

Abstract: The present invention provides a device (1) for detecting contamination with a photosynthesis inhibitor, the device including a collection device (10) configured to collect a test liquid, a light-blocking pretreatment tank (21) configured to store the test liquid (2) collected by the collection device in a state of containing phytoplankton, a stirring device configured to maintain a floating state of the phytoplankton in the test liquid stored in the pretreatment tank, an irradiation light source configured to irradiate the phytoplankton in the test liquid stored in the pretreatment tank with weak light having an underwater photon flux density that does not cause photoinhibition, a drainage conduit (40) configured to allow the test liquid discharged from the pretreatment tank to flow thereinto, and a fluorescence quantum efficiency measuring machine (50) provided for the drainage conduit and configured to measure a fluorescence quantum efficiency of the phytoplankton in the test liquid discharged from the pre

Abstract: Eye cups and retinal imaging systems including an eye cup are described. In an embodiment, the eye cup is shaped to couple with an eyepiece lens assembly. In an embodiment, the eye cup includes a concave socket shaped to couple to a periorbital region of an eye, the concave socket defining a viewing aperture positioned to align with a pupil of the eye along a longitudinal axis of the viewing aperture when the concave socket is coupled to the periorbital region; and a flange extending from the concave socket away from the longitudinal axis and shaped to couple with a lateral margin of the periorbital region when the concave socket is coupled to the periorbital region. In an embodiment, an outer edge of the flange extends farther from the longitudinal axis than an outer edge of portion of the concave socket.

Abstract: The present disclosure relates to methods and intermediates for the synthesis of certain compounds that inhibit MCL1, for use in the treatment of cancers.

Abstract: Methods and compositions for the adsorptive removal of methyl tertiary butyl ether (MTBE) from contaminated water sources and systems. The compositions contain carbon fly ash doped with silver nanoparticles at specific mass ratios. Methods of preparing and characterizing the adsorbents are also provided.

Abstract: Disclosed is a method for carrying out ecological water supplement by using tidal power, including the following steps: constructing a first water supplying river channel at an upper and middle reach of an artery and tributaries of a river channel, storing water at high tide and supplying water to the tributaries at low tide based on the first water supplying river channel; and setting a storage tank at an urban river channel, constructing a second water supplying river channel at an other end of the storage tank connected with the urban river channel, and supplying the water to a city based on the interconnected storage tank, the urban river channel and the second water supplying river channel.

Abstract: Antibodies that bind Her2, EGFR, Trop2, CDH3 or other TAAs containing a triple mutation at L234A, L235A, and L328C and methods of making such triple mutated antibodies are disclosed herein. Consequently, the triple mutated antibodies contain a modified effector function through Fc silencing and are capable of site-specific conjugation at L328C to form an antibody-drug-conjugate (ADC) which can be administered to patients and provide a method of treating cancer, immunological and neurological disorders.

Abstract: Methods are provided for producing a biaxially oriented nanoporous UHMWPE membrane. The method can include combining a petroleum jelly, an ultra-high-molecular-weight polyethylene (UHMWPE), and an antioxidant, forming a suspension, feeding the suspension into an extruder to produce a gel filament, pressing the gel filament to form a gel film, subjecting the gel film to an annealing temperature, and extracting the petroleum jelly from the gel film.

Abstract: An MRAM cell includes a switch unit configured to determine opening and closing thereof by a word line voltage and to activate a current path between a bit line and a bit line bar in an opened state thereof, first and second MTJs having opposite states, respectively, and connected in series between the bit line and the bit line bar, to constitute a storage node, and a sensing line configured to be activated in a reading mode of the MRAM cell, thereby creating data reading information based on a voltage between the first and second MTJs, wherein the first and second MTJs have different ones of a low resistance state and a high resistance state, respectively, in accordance with a voltage drop direction between the bit line and the bit line bar, thereby storing data of 0 or 1.

Abstract: Introduced here are diagnostic platforms able to optimize computer-aided diagnostic (CADx) models by simulating the optical performance of an imaging device based on its mechanical components. For example, a diagnostic platform may acquire a source image associated with a confirmed diagnosis of a medical condition, simulate optical performance based on design data corresponding to a virtual prototype of the imaging device, generate a training image by altering the source image based on the optical performance, apply a diagnostic model to the training image, and then determine whether the performance of the diagnostic model meets a specified performance threshold. If the diagnostic model fails to meet the specified performance threshold, the diagnostic platform can automatically optimize the diagnostic model for the imaging device by altering its underlying algorithm(s).

Abstract: Disclosed are a targeted and long-lasting passivation material for soil cadmium immobilization, and a preparation method and use thereof. In the disclosure, the passivation material is a mercaptosuccinic acid-intercalated calcium iron aluminum hydrotalcite, which is prepared by hydrothermal co-precipitation of a metal salt dispersion and an intercalation solution in an alkaline environment.

Abstract: A technique for generating and presenting context-aware recommendations to assist a patient in managing a chronic health condition. A health management platform provides various services that are accessible to a patient via a graphical user interface (GUI). Input data are received from various services and processed to generate contextual data associated with the patient such as a health state of the patient. Using the contextual data, a recommendation to access a particular service is generated and presented to the patient via the GUI. For example, in response to determining a health state of a patient, a recommendation to access a service to improve the health state of the patient can be automatically presented via the GUI to encourage the patient to access the service.

Abstract: A method for implementing an atomic clock based on NV-15N coupling spin system in diamond and a device are provided. The method includes: applying a pulse sequence to jointly initialize NV electron spins and 15N nuclear spins; performing a Ramsey interferometry to compare a RF frequency and a 15N hyperfine coupling; entangling the NV electron spin and the nuclear spin, reading out a state of nuclear spins by collecting a fluorescence signal; calculating a frequency difference between the RF frequency and the 15N hyperfine coupling according to the fluorescence signal, thereby locking the RF frequency to the 15N hyperfine coupling; and outputting the RF frequency as a frequency standard.

Abstract: The present application discloses a processor video memory optimization method and apparatus for deep learning training tasks, and relates to the technical field of artificial intelligence. In the method, by determining an optimal path for transferring a computing result, the computing result of a first computing unit is transferred to a second computing unit by using the optimal path. Thus, occupying the video memory is avoided, and meanwhile, a problem of low utilization rate of the computing unit of a GPU caused by video memory swaps is avoided, so that training speed of most tasks is hardly reduced.

Abstract: Disclosed are a method of manufacturing a carbon support for a fuel cell catalyst, a carbon support for a fuel cell catalyst manufactured according to the method, and a catalyst for a fuel cell including the same. The method may include using various organic materials containing N and various carbon supports and thus provide excellent economic feasibility. In addition, pyridinic N and pyrrolic N of doped N can be adjusted at an optimal content ratio so that the carbon support for a fuel cell catalyst manufactured and the catalyst for a fuel cell including the same have excellent electrochemical resistance and excellent electrochemical characteristic due to an increase in an electrochemically active surface area, and excellent durability due to an increase in thermal durability.

Abstract: An endovascular system includes inner and outer catheters, a handle system operably coupled one end of the catheters, and a microvalve coupled to the other end of the catheters. The microvalve is constrained in a radially-collapsed closed configuration for advancement within a vessel to a treatment site. The handle system is operable to displace the inner and outer catheters portions relative to each other to move the microvalve between closed and open configurations. An indicator is provided to visually indicate the extent by which the microvalve is opened within the vessel.

Abstract: Provided herein are immunomodulatory proteins that exhibit neutralizing activity of BAFF and APRIL (or BAFF/APRIL heterotrimers). The immunomodulatory proteins provided herein include variant domains of Transmembrane Activator and CAML Interactor (TACI). Among provided immunodulatory proteins are TACI-Fc fusion proteins. Also provided are nucleic acid molecules encoding the immunomodulatory proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological diseases, disorders or conditions. Also provided are compositions and methods for making and using such proteins.