Abstract: The invention relates to an intersomatic implant designed to be inserted in the disk space defined between two adjacent vertebrae, namely an overlying vertebra and an underlying vertebra, for the purpose of reestablishing the anatomic space between the vertebrae, the implant being in the form of a cage (1) that is generally in the shape of a rectangular block having at least two sagittal walls (2, 3) interconnected at least by an anterior transverse wall (4) and by a posterior transverse wall (5), the walls (2 to 5) presenting rims (10) extending on one surface to define a first transverse face (8) and on the other side to define a second transverse face (9). According to the invention, the implant comprises: a first transverse face (8) presenting in the sagittal plane a convex profile congruent with the sagittal anatomic profile of an overlying vertebra; and a second transverse face presenting in the frontal plane a convex profile congruent with the frontal anatomic profile of an overlying vertebra.

Abstract: A subject of the present invention is a method for the selective concentration of a macromolecule or of an agglomerate of molecules of particles contained in a liquid sample, comprising successively the following steps: formation of a stabilized dispersion of foam or emulsion type, from a medium comprising said liquid sample and an interface layer, said interface layer being capable of selectively fixing said macromolecule or said agglomerate to be concentrated; and resorption of the dispersion formed during the preceding step so as to reform said interface layer. The present invention can be applied to the concentration of DNA, of proteins, of prions, of colloidal particles.

Abstract: The present invention provides antibodies that specifically bind RSP-2 proteins which are involved in the cytoadhesion of P. falciparum during ring-stage infection of erythrocytes as well as methods of using these antibodies.

Abstract: An intervertebral linking device of the type comprising bone anchoring elements to be interconnected by at least one intervertebral linking rod. The intervertebral linking device includes a the fixing system mounted on a connection bar the fixing system including at least one sliding displacement of the fixing system associated with a locking nut to lock said system in a fixed position. The connection bar is mounted on each anchoring element a guiding collar in rotation around an axis of the connection bar and locking the connection bar in a fixed specific position.

Abstract: The present invention relates to a hepatic cell line derived from wild-type mammalian liver tissue by culture methodology, the cells of the cell line being capable of differentiating into hepatocytes and bile duct cells. The present invention also relates to methods of producing such cells as well as to their applications in therapy and as an investigational tool.

Abstract: A clamping nut suitable for co-operating with a threaded shank of an osteosynthesis appliance, the nut comprising an annular body and a tapped bore for cooperating with the threaded shank, the annular body being provided with turning means and with a transverse bearing face.

Abstract: In the osteosynthesis device of the invention, the elastically deformable connection system comprises:

Abstract: A lumbar intersomatic implant for insertion into the discal space between two adjacent vertebrae for reestablishing the anatomical intervertebral space, the implant being in the form of a generally rectangular cage having two sagittal walls interconnected by at least an anterior transverse wall and a posterior transverse wall, the walls defining between them an open volume for filling with bone. An “outer” one of the sagittal walls of the implant presents a top rim and a bottom rim each shaped to present at least one retention edge extending substantially in the sagittal plane, making insertion via a posterior path possible, and an outer face arranged to present a penetration assisting shape enabling the cage to be offset transversely to a locking position in the discal space, which position is obtained by the retention edge preventing the cage from being reversed transversely.

Abstract: The invention concerns a method for detecting intrachromosome imbalance in interphase nuclei, characterised in that it consists in: (a) hybridising in situ the chromosome suspected to be affected by said imbalance using two probes marked with different fluorochromes and specific of said chromosome long arm and short arm respectively; (b) measuring the intensity of the fluorescence emitted in said nuclei with different emission wavelengths corresponding to each of the two fluorochromes; (c) calculating the ratio (Ra) between the two measured values of fluorescence intensity; and (d) comparing the resulting ratio value with at least one reference value. The invention also concerns a kit for implementing said method and uses of said kit and said method, in particular for detecting cancer cells in a biological sample and for diagnosing cancer pathologies.

Abstract: An eddy current detector (4) comprises two poles aligned in the direction of extension of partitions (3) located behind a wall (2) wherein the thickness must be measured, but which interfere with the measurements. The influence of the partitions (3) is decreased if the core (6) of the detector (4) comprises two poles aligned in the direction of the extension of the partitions (3) and if a logical system is used to correct the results obtained according to preliminary results obtained on a reference surface.

Abstract: A system and method for managing the transfer of data within an operational store is disclosed. Data from a plurality of distributed data sources is received at a messaging workflow module. The messaging workflow module prioritizes incoming and outgoing data and requests for data. Data is transferred from messaging workflow module to a translation module which ensures that the data is in a proper format for the operational data store. Data is transferred from translation module to the operational data store.

Abstract: 3-(amino- or aminoalkyl) pyridinone derivatives having the formula (1) 1

Abstract: The invention relates to an anterior osteosynthesis plate for lumbar-lumbar or lumbar-sacral vertebrae, the plate being of the type comprising: an elongate body: adapted to cover of the anterior portions of two consecutive vertebrae; possessing an anterior face (6) and an opposite posterior face (7); presenting end zones that are interconnected by a connection zone (11); and provided with two through holes for anchoring screws.

Abstract: A disk prosthesis for cervical vertebrae. The prosthesis includes a spherical cap formed on a first insert, while a spherical cup is formed on a second inset, two inserts made of ceramic material, one of the inserts being mounted on a first plate while the other insert is mounted on a second plate in such a manner that the center of rotation of the joint is substantially centered relative to the edges of the plates, a spherical cup possessing a contact surface area that is not less than that of the spherical cap and being connected via an annular molding to the base of the insert, and a plate provided with the insert having the spherical cap includes an annular setback to leave clearance for the annular molding.

Abstract: A spinal implant device arranged to clamp at least one vertebra includes a link rod, a hook defining a central bore and secured to a fixing head, a counterhook, an elongate member, a position control device and an interconnection arrangement between the counterhook and the hook. The fixing head has a pair of upwardly extending members forming a channel configured to accommodate the link rod. A nut engages the fixing head to exert a downward force onto the link rod. The elongate member attaches at one end to the counterhook and slidably engages the central bore of the hook such that the hook and the counterhook cooperate to define a clamp. The position control device cooperates with the hook and the elongate member to selectively maintain the hook in a position relative to the counterhook.

Abstract: An intervertebral link device including at least one damper element constituted by a cage and a pin designed to be connected to bone anchor elements. The pin being engaged in a housing of the cage and being fitted with two elastically deformable members operating in opposition to an applied traction force or compression force. The damper element includes a pin that is mounted inside the cage by a joint allowing multidirectional relative pivoting between the pin and the cage, at least about the axes contained in a plane perpendicular to the pin and angular abutment between the cage and the pin enabling the multidirectional relative pivoting to be limited in amplitude to a determined value of about 4°.

Abstract: A system for intersomatic fusion and setting of vertebrae. The system includes at least one open internal cage arranged for receiving spongy bone or bone substitute and is designed to be interposed between two vertebrae during diskectomy. The cage (1) includes on its anterior face (5) an external element forming a plate (12) extending in a plane substantially perpendicular to the insertion plane of the cage (1), and has at each of its ends an anchor device (13,14) adapted for anchoring to at least two adjacent vertebrae to be secured to each other by the cage (1). The system can be separated into two parts, the cage and the plate.