Abstract: Provided herein is a class of anti-cancer conjugates designed to cross the blood-brain barrier (BBB) and thereby deliver a methylation agent into cancerous tumor cells, wherein the conjugate comprises a BBB-shuttle moiety that allows the conjugate to cross the BBB, and at least two methylation moieties of the methyltriazene type attached thereto for effecting DNA methylation in the cancerous cells. Also provided are uses of the conjugates in the treatment of brain cancer.

Abstract: A method of determining perturbation of a grating formed in an optical fiber, comprises: modulating and transmitting a light beam through the optical fiber, measuring at least one phase shift in a modulation of light reflected off the grating, and determining the perturbation of the grating based on the phase shift(s).

Abstract: A method for producing parameters for product design. The method comprises receiving explicit or implicit preferences, directly or indirectly, from customers, and constrains from at least one provider. The method includes mapping the preferences and constraints to a space, where searches for an optimum are limited according to the constraint. The parameters for product design are produced according to at least one optimum found. The method may be performed by a system which comprises at least one processor adapted to execute code and at least one memory storing a preference data structure, designed in accordance with the space.

Abstract: An upconversion system, including: a glow discharge device (GDD) configured to detect signal source radiation, wherein the signal source radiation is at least one of millimeter wave (MMW) radiation and Terahertz (THz) radiation; and a photodetector configured to measure intensity changes in visible light emitted by said GDD as a result of absorption of the signal source radiation. The upconversion system optionally includes a processor operatively coupled to the photodetector. The processor is configured to analyze imagery captured by the photodetector, and to compute at least one parameter of the signal source radiation based on the imagery.

Abstract: Disclosed are selectively-permeable membranes and components configured for selective permeation of a specified gas, such as oxygen, therethrough, methods for making the same and methods for using the same, for example, to implement fuel cells and electrochemical cells.

Abstract: System and method for locating a fault on a line comprises a sampler that samples a pulse from the fault, the sampling being carried out at a predetermined sampling rate. A differentiator produces a differential or derivative of the pulse, and an analyzer obtains timing information from the derivative, from which it is possible to locate the fault knowing the total length of the line and the wave propagation rate.

Abstract: Disclosed are methods and devices suitable for growing algae.

Abstract: Provided herein is a conjugate comprising two residues of structurally and/or mechanistically different anticancer bioactive agents, coupled to one another by a biocleavable linking moiety, as well as methods of treating cancer using the same and pharmaceutical compositions comprising the same.

Abstract: A generator comprises a parallel plate capacitor which in turn is made up of a mobile plate and a stationary plate, the plates facing each other in parallel at their internal faces. The mobile plate moves up and down due to an external mechanical force to increase and decrease the gap between the plates, leading to a change in the capacitance between the mobile plate and the stationary plate. The internal faces of the plates have dielectric surfaces, for example formed by oxidizing. The generator is useful for example for small-scale mobile devices such as wearables, and to any device where motion is available to transform into electricity.

Abstract: The present invention solves the existing problem of using very expensive oxidation reagents, such as H2O2 and ozone, in removal of NOx and SOx from flue gases, by performing simultaneous oxidation of NOx and SOx with atmospheric oxygen in a combined system for catalytic oxidation and wet-scrubbing of both NOx and SOx from a flue gas and manufacturing fertilisers. Two major configurations of the oxidation system are disclosed in the present invention. The first configuration operates on oxygen-enriched air to increase efficiency of the oxidation reaction and requires an additional oxygen concentrator unit. The second configuration operates on atmospheric air at ambient conditions and requires an additional catalyst activation unit. In the second configuration, the efficient oxidation process is carried out at low temperatures of about 30-90° C. in the presence of recovered and re-activated catalyst.

Abstract: A NOx and SOx oxidation with atmospheric oxygen to remove NOx and SOx from flue gases. The combined system for catalytic oxidation and wet-scrubbing of NOx and SOx from a flue gas and manufacturing fertilizers includes: an air separation unit for separating atmospheric oxygen from air and producing an air stream enriched with atmospheric oxygen, an adsorption and oxidation reactor containing an oxidation catalyst and carrying out the catalytic oxidation of NOx and SOx by said oxygen to yield nitric and sulphuric acids, a separator and reactor control unit for separation of products and liquids and controlling the reaction; and a vessel containing ammonia streaming said ammonia into the reactor or into the control unit to react with the nitric and sulphuric acids and to yield the fertilizers.

Abstract: An interferometer system comprises a sample interferometer arm for guiding a first wave to a sample, and receiving a reflected wave from the sample and a phase amplifier for amplifying a phase shift of the reflected wave, to provide phase-shift-amplified intermediate wave. The interferometer system can also comprise an additional interferometer arm for guiding an additional wave to combine with the intermediate wave, to provide an output wave, and a detector for detecting the output wave.

Abstract: A method of treating an inflammatory disease or disorder is disclosed. The method comprises administering to the subject a therapeutically effective amount of a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 11-15. The inflammatory disease is not cancer, osteoporosis, rheumatic arthritis, osteoarthritis or angiogenesis-related eye disease.

Abstract: A method of reducing a substrate and a system for reducing a substrate are described herein. The method comprises contacting the substrate with a catalytic amount of zero valent iron particles and with a reducing agent, wherein the zero valent iron particles mediate transfer of an electron, hydrogen atom and/or hydride ion from the reducing agent to the substrate. The system comprises zero valent iron particles embedded in a porous matrix, wherein the system is configured for contacting the substrate and a reducing agent with a catalytic amount of the zero valent iron particles in the porous matrix.

Abstract: An applicator for no-bath plasma gel electrolytic oxidation of a workpiece made of a valve metal or an alloy thereof; the applicator movable over a surface of a workpiece to be treated. The applicator including an electrode connectable to a power supply and configured for applying electric voltage to a gap between the electrode and a workpiece. A gel electrolytic medium body is mounted in a holder being in an electric contact with the electrode.

Abstract: Apparatus and method for detecting a dissolved gaseous impurity in an aqueous environment, comprises a tube for isolating liquid surface, or a sampler for obtaining a liquid sample from the aqueous environment, a vacuum pump located to exert a vacuum, leaving the surface to evaporate into the vacuum; and a holding compartment for holding evaporated gas which may then be analyzed using electrochemical or spectroscopic methods. The apparatus is useful for detecting levels of ammonia in fish ponds or indeed any impurity that may be dissolved in the water.

Abstract: A method of spectroscopy, comprises: transmitting output radiation to a sample; collecting from the sample input radiation being indicative of interaction between the output radiation and the sample; modulating at least one of the output radiation and the input radiation, wherein at least one of the output radiation and the modulation is characterized by a scanned parameter; combining the input radiation, following the modulation, with a reference signal to provide a combined signal; processing the combined signal to construct a vector describing a dependence of a radiation property of the input radiation on the parameter; and at least partially identifying the sample or a change in comprises sample based on at least the vector.

Abstract: Disclosed are devices suitable for performing chemical and/or biological reactions. Also disclosed are methods of simultaneously performing at least two chemical and/or biological reactions under different conditions in a single reaction chamber.

Abstract: According to some embodiments of the present invention there is provided a method for detecting locations of navigation interfering devices. The method comprises an action of receiving multiple navigation signal parameter datasets, each from one of multiple satellite signal receivers. The method comprises an action of detecting one or more interference event data according to an interference analysis of at least some of the datasets. The method comprises an action of updating a probability value for each of multiple suspected navigation interference device locations, by a location analysis of the interference event data, where each of the probability values is indicative of a likelihood that the interference event data originates from some of the suspected navigation interference device locations. The method comprises an action of selecting a subset of the suspected navigation interference device locations according to the probability values and outputting the subset.

Abstract: Disclosed are methods and devices suitable for producing an electron beam.