Patents Assigned to Scientific Protein Laboratories, LLC
  • Method for reducing or inactivating viral and microbial content in the processes for the manufacture of pancreatin
    Patent number: 11952603
    Abstract: A pancreatin preparation having reduced viral infectivity includes one or more pancreatin enzymes and peracetic acid (PAA). At least one pancreatin enzyme may be derived from an animal source such as a porcine pancreas gland. In a particular embodiment, the one or more pancreatin enzymes are selected from the group consisting of lipases, proteases, and amylases.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: April 9, 2024
    Assignee: SCIENTIFIC PROTEIN LABORATORIES, LLC
    Inventors: Kenneth S. Manning, Yan Wang, Dustin Nielsen, Ryan Ruf, Colin Crowley, Jon Restivo, Dana Spangenberg, Karla Anhalt, Mark Romich, Anisha Akula, Carmen Fritz
  • Method for Reducing or Inactivating Viral and Microbial Content in the Processes for the Manufacture of Pancreatin
    Publication number: 20180362958
    Abstract: A pancreatin preparation having reduced viral infectivity includes one or more pancreatin enzymes and peracetic acid (PAA). At least one pancreatin enzyme may be derived from an animal source such as a porcine pancreas gland. In a particular embodiment, the one or more pancreatin enzymes are selected from the group consisting of lipases, proteases, and amylases.
    Type: Application
    Filed: August 22, 2018
    Publication date: December 20, 2018
    Applicant: Scientific Protein Laboratories, LLC
    Inventors: Kenneth S. Manning, Yan Wang, Dustin Nielsen, Ryan Ruf, Colin Crowley, Jon Restivo, Dana Spangenberg, Karla Anhalt, Mark Romich, Anisha Akula, Carmen Fritz
  • Method for reducing or inactivating viral and microbial content in the processes for the manufacture of pancreatin
    Patent number: 10093916
    Abstract: A method for the reduction or inactivation of viral and microbial content in the manufacturing of pancreatin API is disclosed. The method includes treating animal-derived tissue with peracetic acid to reduce viral activity and bacterial load prior to processing. In particular, the method includes treating porcine pancreas glands with peracteic acid prior to extracting a pancreatin API from the treated glandular tissue.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: October 9, 2018
    Assignee: Scientific Protein Laboratories, LLC
    Inventors: Kenneth S. Manning, Yan Wang, Dustin Nielsen, Ryan Ruf, Colin Crowley, Jon Restivo, Dana Spangenberg, Karla Anhalt, Mark Romich, Anisha Akula, Carmen Fritz
  • Method for evaluating degradation pathways for pancreatin active pharmaceutical agents
    Patent number: 9677114
    Abstract: Disclosed is a reverse-phase high-performance liquid chromatography based method for evaluating degradation pathways for panctreatin active pharmaceutical ingredients.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: June 13, 2017
    Assignee: Scientific Protein Laboratories, LLC
    Inventors: Anisha Akula, Yan Wang
  • METHOD FOR REDUCING OR INACTIVATING VIRAL AND MICROBIAL CONTENT IN THE PROCESSES FOR THE MANUFACTURE OF PANCREATIN
    Publication number: 20170037392
    Abstract: A method for the reduction or inactivation of viral and microbial content in the manufacturing of pancreatin API is disclosed. The method includes treating animal-derived tissue with peracetic acid to reduce viral activity and bacterial load prior to processing. In particular, the method includes treating porcine pancreas glands with peracteic acid prior to extracting a pancreatin API from the treated glandular tissue.
    Type: Application
    Filed: May 19, 2016
    Publication date: February 9, 2017
    Applicant: Scientific Protein Laboratories, LLC
    Inventors: Kenneth S. Manning, Yan Wang, Dustin Nielsen, Ryan Ruf, Colin Crowley, Jon Restivo, Dana Spangenberg, Karla Anhalt, Mark Romich, Anisha Akula, Carmen Fritz
  • RP-HPLC method for the analysis and quantification of pancreatin active pharmaceutical agents
    Patent number: 9291630
    Abstract: Disclosed is a method for the separation, identification and quantification of multiple proteins in pancreatin active pharmaceutical ingredient samples.
    Type: Grant
    Filed: August 29, 2012
    Date of Patent: March 22, 2016
    Assignee: Scientific Protein Laboratories, LLC
    Inventors: Rachel Wezeman, Lin Rao, Kirk Cryer, Yan Wang
  • Determination of the absence or presence of enterotoxin via a western blot
    Patent number: 9063034
    Abstract: Disclosed is a method for the determination of the absence or presence of bacillus cereus enterotoxin in a protein sample via a western blot.
    Type: Grant
    Filed: October 17, 2012
    Date of Patent: June 23, 2015
    Assignee: Scientific Protein Laboratories, LLC
    Inventors: Dustin Nielsen, Rachel Wezeman, Matthew Bristol, Mark Eifler, Lisa Petersen, Erik Walke, Lin Rao
  • Method to quantify and measure excess colipase in a pancreatin active pharmaceutical ingredient
    Patent number: 9046524
    Abstract: A method for determining the amount of colipase in a pancreatin active pharmaceutical ingredient sample is provided, the method being a titrimetric method with a constant pH and temperature.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: June 2, 2015
    Assignee: Scientific Protein Laboratories, LLC
    Inventors: Anisha Akula, Yan Wang