Abstract: A method refocuses on an optical assembly target surface, using at least one beam originating from a short-pulse optical source, having at least one optical system for focusing the beam on the surface. Refocusing occurs after learning reference conditions for which the assembly is considered as focused. A focusing signal is detected representing a time overlap of the pulses between a beam reflected and a reference beam not reflected by the surface and comes from the source, one of the beams delayed by a delay line, the beam optical path on which the delay line is placed is varied, on the basis of the reference conditions, to cause the focusing signal to reach or go beyond a predetermined threshold. The focus is adjusted on the basis of variation knowledge in the path between the reference conditions and the conditions for which the focusing signal reaches or goes beyond the threshold.

Abstract: The invention relates to an implant material for filling bone defects, for bone regeneration, and for bone tissue engineering, to an implant comprising said material, and to methods for manufacturing such an implant. The hybrid implant material according to the invention comprises: a biodegradable polymer P soluble in at least one solvent S1 and insoluble in at least one solvent S, different from the solvent S1; and a bioactive glass made of SiO2 and CaO and optionally containing P2O5 and/or optionally doped with strontium, characterized in that said implant includes a layering of a porous part having more than 90% by number of pores whose largest dimension is greater than or equal to 100 ?m, and a dense part (2, 20, 200, 2000, 20000) having more than 80% by number of pores whose largest dimension is less than 50 ?m. The invention is useful in the field of bone regeneration, particularly in the field of bone tissue engineering.

Abstract: The invention relates to markers for Crohn's disease and to specific compounds for detecting said markers. The invention also relates to methods for detecting, diagnosing and monitoring the progression of Crohn's disease as well as to methods for evaluating the efficacy of a treatment for said disease, and to compositions and kits that can be used for implementing said methods.

Abstract: Novel hybrid nanoparticles, useful for inhibiting or slowing down the formation of sulfur deposits or minerals in a well during the extraction of gas or oil. Specifically, the nanoparticles each include (i) a polyorganosiloxane (POS) matrix; and, optionally as a coating over a lanthanide oxide core, (iii) at least one polymeric scale inhibitor during the extraction of gas or oil. The invention also relates to the method for obtaining the nanoinhibitors and the application of same.

Abstract: The present invention relates to methods and composition for use in the treatment of retinal degeneration, in particular retinal degeneration due to retinal pigment epithelium dysfunction.

Abstract: The present invention relates to the use of a nucleic acid molecule encoding a first reporter gene, bordered by at least one first pair and one second pair of sequences targeting a site-specific recombinase in order to detect cells of a mammal infected with a virus responsible for an immunodeficiency.

Abstract: The present invention relates to the field of organic lithium batteries having high energy and power densities. In particular, the present invention relates to an organic lithium battery comprising a positive electrode based on redox organic compounds and a porous separator made of biaxially oriented polypropylene, and to its process of manufacture.

Abstract: A material belonging to the family of centrosymmetric Mott insulators is used as an active material in a resistively switched memory for storing data. The material is placed between two electrical electrodes, by virtue of which an electric field of a preset value is applied in order to form, by way of an electron avalanche effect, an elementary information cell that has at least two logic states.

Abstract: Synthesizing poly(alkoxyamine amide)s, which have a monomer chain with at least one thermolabile bond between monomers from an acid monomer of a monohalogenated carboxylic acid X—C(R,R?)—Y—COOH and an amine monomer having a free terminal free-radical nitroxide group >N—O? and a free terminal primary amine —NH2. The synthesis involves two separate and chemically selective chemical reactions. One reacts the —COOH and —NH2 groups to obtain an amide bond —NH—CO—Y—C(R, R?)—, and the other reacts the —Y—C(R, R?)? free-radical with the nitroxide function >N—O? in order to obtain an alkoxyamine bond —Y—C(R, R?)—O—N<. The chemical reactions are performed in alternating fashion with catalysts and a novel halogenated acid monomer X—C(R,R?)—Y—COOH or a novel free-radical amine monomer having a free terminal group >N—O? and a free terminal primary amine —NH2, until a complete copolymer chain is obtained. Also the polymers obtained and the uses thereof.

Abstract: A magnetic field sensor includes first and second sensors for detecting first and second magnetic components according to first and second directions. Each sensor includes a flux concentrator including first and second magnetic parts, an air gap between the parts, and a magnetoresistive element in the air gap. Each magnetoresistive element includes a reference layer having a fixed magnetization direction, the fixed magnetization direction of the first and second sensors being substantially identical, and a sensitive layer having a variable magnetization direction, the variable magnetization direction of the first sensor when the first sensor is in a state of rest being substantially identical to the variable magnetization direction of the second sensor when the second sensor is in the state of rest. The air gaps of first and second sensor are oriented parallel to a direction XY which is, at ±15°, the bisector of the first and second directions.

Abstract: A compound is provided which has a structure I: A-B-C and a method for administering the compound is also provided for use in the prophylaxis and/or treatment of a viral infection, and in particular for preventing and/or inhibiting viral replication, in which A is a quinoline or quinoline-like group, B is a sole amino acid or a peptide or polypeptide having a given amino acid sequence, and C is an O-phenoxy group. According to one embodiment, the compound is a protease inhibitor such as a caspase inhibitor, and the inhibitor can be Q-VD-OPh (N-(2-(quinolyl)valylaspartyl-(2,6-difluorophenoxyl)methyl ketone), optionally in an O-methylated form. Antiviral compositions and kits are also provided.

Abstract: The present invention relates to a method for treating spinal muscular atrophy and other related neuromuscular disorders in a subject in need thereof, said method comprising administering a therapeutically effective amount of an ERK inhibitor, such as Selumetinib to said subject.

Abstract: An image sensor having photosites forming an array (K×L) of K rows and L columns, including a first set of integrator circuits, with a first regulation by analog weighting in blocks of n×n? photosites, said photosites belonging to n adjacent columns and to n? adjacent rows, and a second set of integrator circuits, with a second regulation by analog weighting in blocks of m×m? photosites, said photosites belonging to m adjacent columns and to m? adjacent rows, n adjacent columns of a first set of columns of the array being connected to n×n? integrator circuits of the first set, m adjacent columns of a second set of columns of the array being connected to m×m? integrator circuits of the second set, n columns of the first set alternating with m columns of the second set to form the array of photosites.

Abstract: The invention relates to a method of testing an infant, comprising the following steps: displaying a target on a screen; detecting contact made by the infant with the screen inside and/or outside the target; calculating a success parameter on the basis of the contact detected; and recording the calculated success parameter in a memory.

Abstract: The present invention relates to a solar surface receptor module that operates at a high temperature and comprises a channel (101) extending therethrough and along which a heat transfer occurs between a fluid (liquid or gas) moving in said channel (101) and at least one wall (104) of the receptor exposed to concentrated solar radiation, characterized in that the inner surface (105) of at least said wall includes turbulence-generating actuators (110) at the fluid inlet (102). The present invention also relates to a solar receptor therefor.

Abstract: Methods for preventing or treating retroviral infection not HIV and/or for preventing, inhibiting or treating a disease caused by the retroviral infection include contacting a cell with compound (I) wherein: means a pyridazine, pyrimidine or pyrazine group, R independently represent a hydrogen atom, halogen atom or group chosen among a —CN, hydroxyl, —COOR1, (C1-C3)fluoroalkyl, (C1-C3)fluoroalkoxy, —NO2, —NR1R2, (C1-C4)alkoxy, phenoxy and (C1-C3)alkyl group, the alkyl being optionally mono-substituted by hydroxyl group, n is 1, 2 or 3, n? is 1 or 2, R? is a hydrogen atom, halogen atom or group chosen among (C1-C3)alkyl group, hydroxyl group, —COOR1 group, —NO2 group, —NR1R2 group, morpholinyl or morpholino group, N-methylpiperazinyl group, (C1-C3)fluoroalkyl group, (C1-C4)alkoxy group and —CN group, Z is N or C, Y is N or C, X is N or C, W is N or C, T is N or C, U is N or C.

Abstract: The invention concerns compositions that can be cured in the presence of water or atmospheric moisture comprising at least one polyorganosiloxane having one or a plurality of condensable group(s) or hydrolysable and condensable group(s) and at least one compound capable of catalyzing the condensation reaction of the condensable or hydrolysable and condensable groups of the polyorganosiloxane. This compound is a heterometallic complex of which the chemical formula comprises at least two different metal atoms M and M?, M being an atom chosen from the group consisting of the atoms of columns 2 and 13 of the periodic table and M? being an atom chose from the group consisting of the atoms of column 4 of the periodic table, and at least one alkoxide or chelating ligand.

Abstract: The invention concerns a composition made from at least one sulphated polysaccharide, in particular from an algae, and combined with at least one food ingredient. This composition can be used, in particular, in the field of food or in the treatment or prevention of an infection caused by microsporidia in humans or animals. It has useful properties as an antiparasitic agent in humans or animals; for the treatment or prevention of an infection caused by at least one microsporidia in humans or animals; in particular for the treatment or prevention of an infection caused in bees by the microsporidia Nosema, preferably Nosema ceranae or Nosema apis, or indeed for stimulating the immune defences of bees.

Abstract: The disclosure relates to the fabrication of a three dimensional [3-D] cell culture membrane comprising one or more functionalized surfaces adapted to provide cell culture conditions suitable for the analysis of proliferation, differentiation or function of cells, typically eukaryotic or prokaryotic cells.

Abstract: A system and method are provided which employ a neural network model which has been trained to predict a sequentialized form for an input text sequence. The sequentialized form includes a sequence of symbols. The neural network model includes an encoder which generates a representation of the input text sequence based on a representation of n-grams in the text sequence and a decoder which sequentially predicts a next symbol of the sequentialized form based on the representation and a predicted prefix of the sequentialized form. Given an input text sequence, a sequentialized form is predicted with the trained neural network model. The sequentialized form is converted to a structured form and information based on the structured form is output.