Abstract: The invention concerns an aminoquinoline-antibiotic hybrid compound of general formula (I): Q—(Y1)p—(U)p—(Y2)p-A: wherein Q represents an aminoquinoline, (Y1)p(U)p—(Y2)p? is an optional spacer and A is an antibiotic residue. The invention enables the antibiotic residue activity to be unexpectedly enhanced.

Abstract: The invention relates to a composition comprising a macromolecule or particle having one or several hydrophobic domains on the surface thereof whereby at least one transducer peptide is adsorbed thereon. Said composition can be used to introduce the macromolecule or particle into living cells.

Abstract: The invention relates to indole-derived compounds and to the use of said compounds for the preparation of a medicament that can be used to treat diseases related to the process of splicing pre-messenger RNAs in the cell, such as Frasier syndrome, frontotemporal dementia linked to chromonsoem 17 (a form of Parkinson's disease), Leigh syndrome (a type of encephalopathy), atypical cystic fibrosis, certain neuropathologies including Alzheimer's disease linked to a mutation in the Tau protein, muscle atorphy which affects the SMN (survival of Motor Neuron) gene, depression linked to a serotonin splicing impairment, and certain cancers in which the global splicing process is affected (e.g. breast cancer, colon cancer and certain lymphomas), as well as viral diseases such as AIDS.

Abstract: A coaxial probe for near-field measurements including a connection wire of which a first end is connected to a connector, the connection wire covered with a dielectric substrate and a shield to form a waveguide. The probe has a diameter D equal to at least 300 micrometers.

Abstract: The invention relates to a method of preparing DNA fragments by selective fragmentation of nucleic acid fragments. The inventive method comprises a first selection step involving selection of short fragments, consisting in: a) preparing first double-stranded DNA fragments F1 using at least one restriction enzyme E1 which can randomly fragment the nucleic acid sample to be analysed, by generating said DNA fragments F1 with blunt or cohesive ends; b) ligating the ends of the DNA fragments F1 obtained in step (a) to at least one adapter AA?; c) cleaving the DNA fragments F1 obtained in step (b) using a restriction enzyme E2, such as to select a fraction of short fragments F2; and d) using any suitable means to purify the aforementioned fraction of short fragments F2.

Abstract: The present invention pertains to a valve actuating device for an internal combustion engine, comprising a magnetic blade controlling the position of the valve and cooperating for this purpose with at least one magnetic circuit comprising at least one magnet for attracting the blade alternately toward a first end position in which the valve is in the closed position and a second end position in which the valve is in the open position. A coil with springs controls the displacement of the blade from one end to the other. The magnetic circuit includes two non-coplanar parts, each of which is approximately C-shaped. A first coil surrounds the main branch of the first part and a second coil surrounds the main branch of the second part. At least one magnet connects the lateral faces opposite the two parts. The corresponding ends of the open branches are approximately coplanar.

Abstract: The invention concerns novel isolated natural or synthetic polynucleotides and polypeptides coded by said polynucleotides, involved in the synthesis of diketopiperazine derivatives, vectors comprising said polynucleotides, micro-organisms transformed with said polynucleotides, uses of said polynucleotides and said polypeptides, as well as methods for the synthesis of diketopiperazine derivatives, including cyclodipeptides and diketopiperazine derivatives 3- and 6-substituted by ?,?-unsaturated amino acid side chains.

Abstract: The invention relates to a titanium aquo-oxo chloride and to a method for its preparation. The compound is in the form of crystals and has the following composition by weight: 26.91% Ti; 21.36% Cl; and 4.41% H, which corresponds to the formula [Ti8O12(H2O)24]Cl8.HCl.7H2O. The method of preparation consists in hydrolyzing TiOCl2 either in an atmosphere whose moisture content is maintained between 50 and 60%, or by an alkali metal carbonate A2CO3, in order to obtain a titanium aquo-oxo chloride. The compound is useful as a semiconductor element of a photovoltaic cell or as a photocatalyst in air or water purification treatments.

Abstract: This invention applies in particular to the manufacture of superconducting magnets. A ceramic precursor in the form of a fluid solution is formed, said ceramic precursor being a liquid consisting of a solution comprising water, glass frit and a suspension of clay in water, without any organic element, then a coating for the conductor is formed with said precursor and said coating is heat-treated in order to form the ceramic.

Abstract: A bulk wave acoustic resonant structure which is in accordance with the invention allows the difficulties encountered at high frequency, the impossibility of working at low frequency on simple structures and the absence of an adequate coupling level to be overcome. The invention therefore proposes the use of an additional layer of material which covers the upper electrode of a piezoelectric transducer in order to localize the position of maximum intensity of the dynamic stress close to the centre of the piezoelectric layer through the effect of propagation. The structure that is in accordance with the invention may be associated with Bragg mirrors and various uses are presented.

Abstract: The invention relates to the use of a onium salt functionalized by at least one organic function, as a soluble support, in the presence of at least one organic solvent, for organic synthesis of a molecule, in a homogenous phase, by at least one transformation of said organic function. The onium salt enables the synthesized molecule to be released. The onium salt is present in liquid or solid form at room temperature and corresponds to formula A1+, X1?, wherein A1+ represents a cation and X1? represents an anion.

Abstract: The invention relates to a composite formed of a zeolite (such as ZSM-5 zeolite, ?-zeolite and silicalite) deposited on a rigid support, wherein the rigid support comprises silicon carbide (SiC) with a specific surface area BET of at least 5 m2/g. Preferably, the support is a ?-SiC foam with a specific area of between 10 and 500 m2/g. This composite may be used as a catalyst and/or a catalyst support for chemical reactions in a gas or liquid medium. For example materials of the present invention are useful for example, in connection with cracking, acylation, alkylation and/or isomerization of hydrocarbons.

Abstract: The invention concerns (aryl)(amino)borane compounds and a method for preparing same. Said compounds are of formula A-BH—NR1R2, wherein: R1 and R2 are selected among linear, branched or cyclic alkyl radicals, and arylalkyl radicals, or R1 and R2 form together an alkylene; and A represents an aromatic or heteroaromatic group optionally polycondensed, or a group selected among the vinyl, dienyl, polyenyl and alkynyl groups, all said groups optionally bearing at least one substituent. The compounds are obtained by a method which consists in preparing an amine-borane R1R2NH.BH3 complex, in transforming it into aminoborane R1R2NBH2 by heating, then in reacting it with an A-X compound wherein X is a leaving group.

Abstract: The present invention relates to the deposition in a magnetron reactor (1) equipped with a magnetron cathode (MC) of at least one material on a substrate (11a), according to which process said material is vaporized by magnetron sputtering, using a gas that is ionized in pulsed mode. To this effect and in order to favour the formation of high current pulses of short duration while avoiding the formation of electric arcs and while enabling an effective ionisation of the sputtered vapour, a preionization of the said gas prior to the application of the main voltage pulse on the magnetron cathode (MC) is carried out in order to generate current pulses (CP) whose decay time (Td), after cut-off of the main voltage pulse (VP) is shorter than 5 ?s.

Abstract: The present invention provides novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors according to formula (I) that are useful in the treatment or prophylaxis of physiological and/or pathophysiological conditions in mammals, preferably humans, that are mediated by GHS receptors. The present invention further provides GHS receptor antagonists and agonists that can be used for modulation of these receptors and are useful for treating above conditions, in particular growth retardation, cachexia, short-, medium- and/or long term regulation of energy balance; short-, medium- and/or long term regulation (stimulation and/or inhibition) of food intake; adipogenesis, adiposity and/or obesity; body weight gain and/or reduction; diabetes, diabetes type I, diabetes type II, tumor cell proliferation; inflammation, inflammatory effects, gastric postoperative ileus, postoperative ileus and/or gastrectomy (ghrelin replacement therapy).

Abstract: The present invention relates to the use of a modulator of the expression or activity of the E2IG4 gene for the treatment of diabetes or its complications, obesity or insulin resistance, to a method of screening compounds useful in the treatment of these pathological conditions, and to a method for the diagnosis or prognosis of these pathological conditions.

Abstract: A device for controlling propulsive gas mixing at an outlet of an aircraft jet engine, wherein propulsive jets are composed of a hot primary jet exiting from a nozzle of the jet engine and a secondary flux flowing between an external wall of the nozzle and an internal wall of the jet engine including a divergent trailing edge on the wall that generates conditions of a separation of the primary jet close to an existence limit value and a primary jet controller that enables control of passage of the primary jet from a separated state to a reattached state, and vice versa.

Abstract: The invention relates to novel aminothiol ester compounds having the general formula (I): and to a method for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (cancers and precancers, dermatological, rheumatic and ophthalmological complaints in particular) or in cosmetic compositions. The invention also relates to a pharmaceutical or cosmetic composition, characterized in that it comprises, as active agent, a compound of general formula (I) in combination with a pharmaceutically or cosmetically acceptable support.

Abstract: The invention relates to hyperactive, non-phosphorylated, mutant transposases of mariner mobile genetic elements. The invention also relates to recombinant nucleotide sequences encoding such transposases. The invention further relates to a method of producing said transposases and to the use thereof for in vitro or in vivo transposition.

Abstract: The invention relates to a long-acting solid formulation for parenteral administration, comprising a) triptorelin acetate and b) one or more excipients comprising a polymer or copolymer of lactic and/or glycolic acid or a mixture of polymers and/or copolymers of lactic acid and/or glycolic acid, said formulation containing 10 to 99% of triptorelin acetate by weight with relation to the total weight of the formulation. Said formulation is obtained by means of a method comprising the fusion of a mixture of triptorelin acetate and the excipient(s) on the fusion/extrusion of the triptorelin acetate with the excipient(s), said formulation being embodied such as to release the triptorelin acetate over a duration of at least one week, once administered parenterally to a patient.