Abstract: The invention concerns a method for tuning at a targeted resonance wavelength at least one micro and/or nanophotonic resonator, the resonator having dimensions defining resonance wavelength of said resonator, the resonator being immersed in a fluid containing ions so that the resonator is surrounded by said fluid, wherein the method comprises a step of injecting light, having a light wavelength equal to the resonance wavelength, into the resonator, so that the injected light resonates within the resonator and triggers a photo-electrochemical etching process enabled by the surrounding fluid containing ions, said etching process being enhanced by the optical resonance which amplifies light intensity in the photonic resonator, the etching decreasing dimensions of the photonic resonator, hereby lowering and tuning the resonance wavelength of the photonic resonator.
Type:
Application
Filed:
March 4, 2016
Publication date:
March 1, 2018
Applicants:
Universite Paris Diderot Paris 7, Centre National de la Recherche Scientifique (CNRS )
Inventors:
Ivan Favero, Christopher Baker, Eduardo Gil Santos
Abstract: The invention concerns a method of forming a medical device, the method comprising: forming a graphene film (100) over a substrate (204); depositing, by gas phase deposition, a polymer material covering a surface of the graphene film (100); and removing the substrate (204) from the graphene film (100), wherein the polymer material forms a support (102) for the graphene film (100).
Type:
Application
Filed:
March 9, 2016
Publication date:
March 1, 2018
Applicants:
Centre National de la Recherche Scientifique, UNIVERSITE GRENOBLE ALPES
Inventors:
Dipankar KALITA, Vincent BOUCHIAT, Laetitia MARTY, Nedjma BENDIAB
Abstract: The invention relates to a device for capture of cellular biomarkers circulating in an animal or human biological flow, characterised in that it is suitable for use in vivo and in that it comprises a means of filtration intended to retain the said cellular biomarkers, the said means of filtration comprising at least one through-aperture the dimensions of which are suitable for retaining the said cellular biomarkers and being integral with a support, the support taking the form of a hollow component.
Type:
Application
Filed:
February 2, 2016
Publication date:
February 22, 2018
Applicants:
Centre National de la Recherche Scientifique, Centre Hospitalier Universitaire de Toulouse, Universite Toulouse III - Paul Sabatier
Abstract: 1) Hydrocarbon-based polymer of formula (I): in which F1 and F2 have the respective formulae (IIa) and (IIb) or (II?a) and (II?b): a process for its preparation, and use as an adhesive.
Type:
Application
Filed:
August 15, 2017
Publication date:
February 22, 2018
Applicants:
Bostik SA, Universite De Rennes I, Centre National De La Recherche Scientifique
Abstract: The present invention relates to a thiol compound suitable for forming a chain of oligomers that can be grafted to an oligonucleotide. The invention also relates to an oligonucleotide grafted by such a compound, thus having one or more thiol functions, suitable for being immobilized on a gold surface or on a grafted surface.
Type:
Grant
Filed:
April 4, 2013
Date of Patent:
February 20, 2018
Assignees:
Etablissement Francais du Sang, Centre National de la Recherche Scientifique (CNRS)
Inventors:
François Morvan, Albert Meyer, Jean-Jacques Vasseur, Julie Mayen, Carole Chaix, Carole Farre, Chantal Fournier-Wirth, Jean-François Cantaloube, Myriam Lereau
Abstract: A germanium waveguide is formed from a P-type silicon substrate that is coated with a heavily-doped N-type germanium layer and a first N-type doped silicon layer. Trenches are etched into the silicon substrate to form a stack of a substrate strip, a germanium strip, and a first silicon strip. This structure is then coated with a silicon nitride layer.
Type:
Application
Filed:
March 6, 2015
Publication date:
February 15, 2018
Applicants:
STMicroelectronics (Crolles 2) SAS, Centre National de la Recherche Scientifique, Universite Paris SUD
Inventors:
Mathias Prost, Moustafa El Kurdi, Philippe Boucaud, Frederic Boeuf
Abstract: The invention relates to the use of a composition from a plant extract of Withania somnifera, to treat or prevent amyloid-related diseases, including Alzheimer disease.
Type:
Application
Filed:
March 23, 2015
Publication date:
February 15, 2018
Applicants:
Ethnodyne, Centre National de la Recherche Scientifique (CNRS)
Abstract: The invention concerns a numerical calculation procedure of the diffraction of a structure (1) whose numerical model defines the dielectric permittivity at each point comprizing the steps of: definition of a numerical modellization of the diffraction model of a structure including: the splitting of the numerical model of the dielectric permittivity into N numerical models of dielectric permittivity; the determination of the diffraction model of the said layers from the numerical model of this layer; numerical calculation of the diffraction of the structure including: an initial iteration during which one performs: one wave propagation in the direction of layers 1 to N, and one wave propagation in the direction of the layers N to 1, ulterior iterations, each ulterior iteration of index k including: one wave propagation in the direction of layers 2 to N: one wave propagation in the direction of layers N?1 to 1.
Type:
Application
Filed:
February 22, 2016
Publication date:
February 15, 2018
Applicants:
Universite Jean Monnet Saint Etienne, Centre National De la Recherche Scientifique
Abstract: The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase or variants thereof possessing endonuclease activity, wherein said PA subunit is from a virus belonging to the Orthomyxoviridae family. This invention also relates to (i) crystals of the polypeptide fragments which are suitable for structure determination of said polypeptide fragments using X-ray crystallography and (ii) computational methods using the structural coordinates of said polypeptide to screen for and design compounds that modulate, preferably inhibit the endonucleolytically active site within the polypeptide fragment. In addition, this invention relates to methods identifying compounds that bind to the PA polypeptide fragments possessing endonuclease activity and preferably inhibit said endonucleolytic activity, preferably in a high throughput setting.
Type:
Grant
Filed:
October 21, 2014
Date of Patent:
February 13, 2018
Assignees:
European Molecular Biology Laboratory (EMBL), Centre National de la Recherche Scientifique, Universite Grenoble Alpes
Inventors:
Denis Bouvier, Thibaut Crepin, Rob Ruigrok, Aelxander Dias, Stephen Cusack
Abstract: A system and method for distillation of a liquid sample at atmospheric pressure for the improved prediction of the heating necessary before the initial boiling point (IBP) of the sample is detected regardless of sample composition to ensure the IBP is observed within certain time constraints. A plurality of infrared (IR) sensors provides real-time temperature control in addition to a conventional measurement of vapor temperature. One IR-sensor monitors the liquid sample temperature in the distillation flask to obtain a corrected IBP time independent of the sample properties. Another IR-sensor monitors the temperature of the rising vapor column as the vapor rises up the neck of the distillation flask. Alternatively, an IR matrix may monitor the temperature of the rising vapor column. The system and method expand the scope of samples analyzed with improved signal, reproducibility, and test accuracy and still remain within the prescribed limits of a selected standard.
Type:
Application
Filed:
August 3, 2016
Publication date:
February 8, 2018
Applicant:
Instrumentation Scientifique de Laboratoire - I.S. L.
Abstract: The invention relates to a chelate resulting from the complexing of a trans-di-N-picolinate tetraazacycloalkane ligand with a metal cation, said ligand corresponding to formula (A) wherein n is equal to 0 or to 1, R is H or a C1-C18 alkyl radical, and R? is H or a C1-C18 alkyl radical, said metal cation being a cation of a metal selected from the group consisting of lead (II) and bismuth (III). The invention is applicable in the field of lead trapping and alpha-radioimmunotherapy.
Type:
Grant
Filed:
June 5, 2014
Date of Patent:
February 6, 2018
Assignees:
CNRS—Centre National de la Recherche Scientifique, Universite de Bretagne Occidentale
Inventors:
Raphael Tripier, Carlos Platas-Iglesias, Luis Lima, Maryline Beyler
Abstract: Disclosed is a process for preparing at least one ether compound, comprising reacting at least one alcohol (I) with at least one polyol (II) in the presence of a functional polymer [polymer (F)] as a catalyst (X), wherein: the alcohol (I) is represented by the general formula (1): R1-OH (1) wherein R1 is a hydrocarbon group having 1 to 36 carbon atoms, the polyol (II) is represented by the general formula (2): R2-(OH) m (2) wherein R2 represents the skeleton moiety of the polyol and m is an integer of from 2 to 20, and polymer (F) is a polymer comprising recurring units derived from at least one ethylenically unsaturated monomer [monomer (M)] and bearing at least one cation exchange group. Further disclosed is a surfactant composition obtained by said process, and featuring an excellent detergency performance.
Type:
Grant
Filed:
October 7, 2014
Date of Patent:
February 6, 2018
Assignees:
Rhodia Operations, Centre National De La Recherche Scientifique
Abstract: Multimodal optical and magnetic resonance imaging methods based on the use of persistent luminescence nanoparticles. Use of mesoporous persistent luminescence <<core-shell>> complexes for theranostic applications.
Type:
Grant
Filed:
January 30, 2013
Date of Patent:
January 30, 2018
Assignee:
Centre National de la Recherche Scientifique (CNRS)
Inventors:
Thomas Maldiney, Cyrille Richard, Daniel Scherman, Didier Gourier, Bruno Viana, Aurelie Bessiere
Abstract: A power-conversion method for a vehicle including a three-phase electric motor, two three-phase inverters, each inverter being controlled via modulation of at least six spatial vectors, the output voltage of each inverter being given by a spatial vector referred to as “reference spatial vector”. The method includes the following steps: applying an activation sequence to the spatial vectors of one inverter, applying an activation sequence to the spatial vectors of the other inverter, subtracting the reference spatial vector of one inverter from the reference spatial vector of the other inverter and supplying the electric motor with electric power, the voltage inducing the electric power being relative to the vector resulting from the subtraction.
Type:
Application
Filed:
January 6, 2016
Publication date:
January 25, 2018
Applicants:
Universite Celrmont Auvergne, Centre Natiaon de la Recherche Scientifique
Inventors:
Khalil EL KHAMLICHI DRISSI, Abbas DEHGHANIKIADEHI, Christophe PASQUIER
Abstract: F1 is formula (IIa) and F2 is formula (IIb): g and d are 0, 1, 2 or 3; R14 and R15 are C1-C4 or a cyclohexyl radical; R1 to R12 represents hydrogen or alkyl with 1 to 22 carbon atoms; x and y are integers, x+y is 0 to 2; R13 is oxygen or sulphur or divalent —CH2— n1, n2, m, p1 and p2 are an integer or equal to 0 and such that the molecular weight Mn of the polymer of formula (I) is between 400 and 100 000 g/mol; a process for preparation of the polymer; and use as adhesive in mixture with an amino compound with at least two amine groups.
Type:
Application
Filed:
July 18, 2017
Publication date:
January 25, 2018
Applicants:
BOSTIK SA, Universite de Rennes I, Centre National de la Recherche Scientifique
Abstract: The present invention relates to a method for treating a Leber congenital amaurosis in a patient harbouring the mutation c.2991+1655 A>G in the CEP290 gene, comprising the step of administering to said patient at least one antisense oligonucleotide complementary to nucleic acid sequence that is necessary for preventing splicing of the cryptic exon inserted into the mutant c.
Type:
Application
Filed:
August 31, 2017
Publication date:
January 18, 2018
Applicants:
INSERM (Institut National de la Sante et de la Rec herche Medicale), CNRS (Centre National de la Recherche Scientifique ), GENETHON, UNIVERSITE PARIS DESCARTES, ENSCP - Chimie ParisTech - Ecole Nationale Superie ure de Chimie de Paris, Universite d'Evry-Val-d'Essonne, ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
Inventors:
Jean-Michel ROZET, Antoine KICHLER, Isabelle PERRAULT, Josseline KAPLAN, Xavier GERARD, Daniel SCHERMAN, M. Arnold MUNNICH
Abstract: According to one aspect, the invention concerns a device for transporting and controlling light pulses for lensless endo-microscopic imaging and comprises: a bundle of N monomode optical fibers (F1) arranged in a given pattern, each monomode optical fiber being characterized by a relative group delay value (Ax) defined relative to the travel time of a pulse propagating in a reference monomode optical fiber (F0) of the bundle of fibers (40), an optical device for controlling group velocity (50) comprising a given number M of waveplates (Pj) characterized by a given delay (8tj); a first spatial light modulator (51) suitable for forming from an incident light beam a number N of elementary light beams (Bi) each of which is intended to enter into one of said optical fibers, each elementary beam being intended to pass into a given waveplate such that the sum of the delay introduced by said waveplate and the relative group delay of the optical fiber intended to receive said elementary light beam is minimal in abs
Type:
Application
Filed:
December 17, 2015
Publication date:
January 11, 2018
Applicants:
Centre National de la Recherche Scientifique, Université d'Aix-Marseille
Abstract: The invention relates to a method for producing a semiconductor structure, characterised in that the method comprises a step (201) of depositing a crystalline passivation layer continuously covering the entire surface of a layer based on group III nitrides, said crystalline passivation layer, which is deposited from a precursor containing silicon atoms and a flow of nitrogen atoms, consisting of silicon atoms bound to the surface of the layer based on group III nitrides and arranged in a periodical arrangement such that a diffraction image of said crystalline passivation layer obtained by grazing-incidence diffraction of electrons in the direction [1-100] comprises: two fractional order diffraction lines (0, ??) and (0, ??) between the central line (0, 0) and the integer order line (0, ?1), and two fractional order diffraction lines (0, ?) and (0, ?) between the central line (0, 0) and the integer order line (0, 1).
Type:
Application
Filed:
January 21, 2016
Publication date:
January 11, 2018
Applicant:
Centre National de la Recherche Scientifique (CNRS)
Inventors:
Fabrice SEMOND, Eric FRAYSSINET, Jean MASSIES
Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of beta-thalassemias. In particular, the present invention relates to an XPO1 inhibitor for use in a method for treating beta-thalassemia in a subject in need thereof.
Type:
Grant
Filed:
November 28, 2014
Date of Patent:
January 9, 2018
Assignees:
INSERM (Institut National de la Sante et de la Recherche Medicale), Universite Paris Decartes, Assistance Publique-Hopitaux de Paris (APHP), Fondation Imagine, Centre National de la Recherche Scientifique (CNRS)