Patents Assigned to Scil Technology GmbH
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Patent number: 9907829Abstract: The present invention relates to stable aqueous formulations comprising at least 5 mg/mL CD-RAP and a charged amino acid, said amino acid preferably having a net charge at a pH between about 6 and 8. The ingredients of the formulation preferably provide stability over repeated freeze-thaw cycles. In a preferred aspect, the formulation is for use in therapy, preferably for use in the treatment of inflammatory disorders, preferably osteoarthritis. Furthermore, a kit comprising the formulation of the invention is provided.Type: GrantFiled: October 27, 2016Date of Patent: March 6, 2018Assignee: SCIL TECHNOLOGY GMBHInventors: Klaus Hellerbrand, Rainer Sigl
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Patent number: 9526761Abstract: The present invention relates to dried reconstituted vesicle (DRV) compositions and water based formulations thereof, which contain one or more therapeutic agents (e.g. hydrophilic protein). More particularly, it relates to DRVs comprising at least one lipid and a fusion promoting agent which after reconstitution form large multilamellar liposomes encapsulating an active agent in an aqueous phase.Type: GrantFiled: April 6, 2009Date of Patent: December 27, 2016Assignee: SCIL Technology GmbHInventors: Klaus Hellerbrand, Andreas Schuetz, Rainer Sigl
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Patent number: 9511116Abstract: The present invention relates to stable aqueous formulations comprising at least 5 mg/mL CD-RAP and a charged amino acid, said amino acid preferably having a net charge at a pH between about 6 and 8. The ingredients of the formulation preferably provide stability over repeated freeze-thaw cycles. In a preferred aspect, the formulation is for use in therapy, preferably for use in the treatment of inflammatory disorders, preferably osteoarthritis. Furthermore, a kit comprising the formulation of the invention is provided.Type: GrantFiled: October 26, 2012Date of Patent: December 6, 2016Assignee: SCIL Technology GMBHInventors: Klaus Hellerbrand, Rainer Sigl
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Patent number: 8829072Abstract: The invention provides a polymer based material comprising a water binding agent present in an amount sufficient to chemically and/or physically absorb and/or adsorb water to prevent degradation of the polymer. The invention also provides a polymer based material comprising a plasticizer or organic solvent as well as a multi-component material or composite including materials encompassing a second polymer and/or an active agent. The invention further provides a pharmaceutical composition comprising the aforesaid polymer based material, which can be used for treatment of bone, cartilage and/or periodontal defects.Type: GrantFiled: January 11, 2013Date of Patent: September 9, 2014Assignee: Scil Technology GmbHInventors: Wolfgang Friess, Klaus Hellerbrand, Samuel Herberg, Cornelius Pompe, Andreas Schuetz, Michael Siedler
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Patent number: 8546334Abstract: The present invention relates to a device having osteoinductive and osteoconductive properties in vivo comprising a carrier containing calcium phosphate and an osteoinductive protein, wherein the carrier is homogenously coated with the protein. Moreover, the present invention relates to a method for the production of a device having osteoinductive and osteoconductive properties in vivo. The invention encompasses a pharmaceutical composition comprising the device of the invention or a device which is obtainable by the method of the invention and relates to the use of the device for the preparation of a pharmaceutical composition to be used for bone augmentation, for treating bone defects, for treating degenerative and traumatic disc disease, for treating bone dehiscence or to be used for sinus floor elevation. Finally, the invention relates to a kit comprising the device of the invention or a device which is obtainable by the method of the invention.Type: GrantFiled: March 27, 2002Date of Patent: October 1, 2013Assignee: Scil Technology GmbHInventors: Ulrich Kohnert, Sylke Pohling, Klaus Hellerbrand, Peter Happersberger
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Publication number: 20130137639Abstract: The present invention relates to stable aqueous formulations comprising at least 5 mg/mL CD-RAP and a charged amino acid, said amino acid preferably having a net charge at a pH between about 6 and 8. The ingredients of the formulation preferably provide stability over repeated freeze-thaw cycles. In a preferred aspect, the formulation is for use in therapy, preferably for use in the treatment of inflammatory disorders, preferably osteoarthritis. Furthermore, a kit comprising the formulation of the invention is provided.Type: ApplicationFiled: October 26, 2012Publication date: May 30, 2013Applicant: SCIL TECHNOLOGY GMBHInventor: Scil Technology GmbH
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Publication number: 20130129666Abstract: The invention provides a polymer based material comprising a water binding agent present in an amount sufficient to chemically and/or physically absorb and/or adsorb water to prevent degradation of the polymer. The invention also provides a polymer based material comprising a plasticizer or organic solvent as well as a multi-component material or composite including materials encompassing a second polymer and/or an active agent. The invention further provides a pharmaceutical composition comprising the aforesaid polymer based material, which can be used for treatment of bone, cartilage and/or periodontal defects.Type: ApplicationFiled: January 11, 2013Publication date: May 23, 2013Applicant: SCIL TECHNOLOGY GMBHInventor: Scil Technology GmbH
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Patent number: 8372419Abstract: The present invention relates to a method of coating of a device, preferably implants, with a substance comprising the steps of (a) contacting said device into a solution of said substrate or substance, and (b) drying said device while being submerged in said solution. The present invention also relates to a packaging container for a device, preferably an implant. Said packaging container being adapted such that said device is coatable within said packaging container. Moreover, the present invention relates to a method of coating the inner surfaces of a packaging container for a device, preferably implants, to be coated by a substance, comprising the steps of (a) siliconizing said inner surfaces of said container using a silicone emulsion, and (b) heat-curing to form a baked-in silicone layer on said inner surfaces of said container.Type: GrantFiled: March 9, 2005Date of Patent: February 12, 2013Assignee: Scil Technology GmbHInventors: Klaus Hellerbrand, Michael Siedler, Andreas Schutz, Bernd Schimkat, Karin Wiedenmann-Schlembach
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Patent number: 8372895Abstract: The present invention relates to a polymer based material comprising a water binding agent, whereas the water binding agent is present in an amount sufficient to chemically and/or physically absorb and/or adsorb water to prevent degradation of the polymer. It also relates to a polymer based material which comprises a plasticizer or organic solvent as well as a multi-component material or composite including materials encompassing a second polymer and/or an active agent. Furthermore it relates to a method for manufacturing the polymer comprising material and use of the material for the preparation of a pharmaceutical composition to be used for treatment of bone, cartilage and/or periodontal defects. The invention also encompasses a kit using the polymeric material.Type: GrantFiled: June 28, 2007Date of Patent: February 12, 2013Assignee: Scil Technology GmbHInventors: Wolfgang Friess, Klaus Hellerbrand, Samuel Herberg, Cornelius Pompe, Andreas Schuetz, Michael Siedler
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Patent number: 8257728Abstract: The present invention relates to a method for producing a device comprising the steps of (a) providing a solution comprising dissolved osteoinductive protein, (b) contacting the solution of the preceding step with a carrier containing a surface of metal or a metal alloy, (c) allowing coating of the surface of said carrier with said dissolved protein and (d) drying of the coated carrier obtained in step (c) wherein steps (b) to (d) are carried out under a reduced concentration of oxygen. The invention also encompasses a device obtainable by the method of the present invention. Moreover, the present invention relates to a pharmaceutical composition comprising the said device and to the use of the device for the preparation of a pharmaceutical composition to be used for an accelerated osseointegration and new bone formation. Finally, the present invention relates to a kit comprising the device of the present invention.Type: GrantFiled: May 28, 2010Date of Patent: September 4, 2012Assignee: Scil Technology GmbHInventors: Klaus Hellerbrand, Nicola Beaucamp, Ulrich Kohnert
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Publication number: 20110020658Abstract: The present invention relates to a method for producing a device comprising the steps of (a) providing a solution comprising dissolved osteoinductive protein, (b) contacting the solution of the preceding step with a carrier containing a surface of metal or a metal alloy, (c) allowing coating of the surface of said carrier with said dissolved protein and (d) drying of the coated carrier obtained in step (c) wherein steps (b) to (d) are carried out under a reduced concentration of oxygen. The invention also encompasses a device obtainable by the method of the present invention. Moreover, the present invention relates to a pharmaceutical composition comprising the said device and to the use of the device for the preparation of a pharmaceutical composition to be used for an accelerated osseointegration and new bone formation. Finally, the present invention relates to a kit comprising the device of the present invention.Type: ApplicationFiled: May 28, 2010Publication date: January 27, 2011Applicant: SCIL TECHNOLOGY GMBHInventors: Klaus Hellerbrand, Nicola Beaucamp, Ulrich Kohnert
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Publication number: 20110002972Abstract: The present invention is related to the use of a repellent factor and/or polypeptide for manufacturing of a pharmaceutical composition for treating a disease such as a degenerative disease in particular to the use of a SLIT3 or NETRIN1 protein therefore. The invention is further related to a polypeptide fragment of SLIT3, a pharmaceutical composition comprising the polypeptide and the use thereof.Type: ApplicationFiled: September 12, 2008Publication date: January 6, 2011Applicant: SCIL Technology GMBHInventors: Anja Bosserhoff, Thomas Schubert, Elisabeth Hustert
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Patent number: 7763270Abstract: The present invention relates to a method for producing a device comprising the steps of (a) providing a solution comprising dissolved osteoinductive protein, (b) contacting the solution of the preceding step with a carrier containing a surface of metal or a metal alloy, (c) allowing coating of the surface of said carrier with said dissolved protein and (d) drying of the coated carrier obtained in step (c) wherein steps (b) to (d) are carried out under a reduced concentration of oxygen. The invention also encompasses a device obtainable by the method of the present invention. Moreover, the present invention relates to a pharmaceutical composition comprising the said device and to the use of the device for the preparation of a pharmaceutical composition to be used for an accelerated osseointegration and new bone formation. Finally, the present invention relates to a kit comprising the device of the present invention.Type: GrantFiled: July 9, 2003Date of Patent: July 27, 2010Assignee: Scil Technology GmbHInventors: Klaus Hellerbrand, Nicola Beaucamp, Ulrich Kohnert
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Publication number: 20090297580Abstract: The present invention relates to a spinal nucleus pulposus implant for use in the treatment of the intervertebral disc and in particular, to the use of a CD-RAP protein therefore.Type: ApplicationFiled: April 6, 2009Publication date: December 3, 2009Applicant: SCIL TECHNOLOGY GMBHInventors: CAROLA DONY, KLAUS HELLERBRAND, ELISABETH HUSTERT, SUSANNE PIPPIG, RAINER SIGL
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Publication number: 20090285880Abstract: The present invention relates to dried reconstituted vesicle (DRV) compositions and water based formulations thereof, which contain one or more therapeutic agents (e.g. hydrophilic protein). More particularly, it relates to DRVs comprising at least one lipid and a fusion promoting agent which after reconstitution form large multilamellar liposomes encapsulating an active agent in an aqueous phase.Type: ApplicationFiled: April 6, 2009Publication date: November 19, 2009Applicant: SCIL Technology GmbHInventors: Klaus Hellerbrand, Andreas Schuetz, Rainer Sigl
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Publication number: 20090209660Abstract: The present invention relates to a polymer based material comprising a water binding agent, whereas the water binding agent is present in an amount sufficient to chemically and/or physically absorb and/or adsorb water to prevent degradation of the polymer. It also relates to a polymer based material which comprises a plasticizer or organic solvent as well as a multi-component material or composite including materials encompassing a second polymer and/or an active agent. Furthermore it relates to a method for manufacturing the polymer comprising material and use of the material for the preparation of a pharmaceutical composition to be used for treatment of bone, cartilage and/or periodontal defects. The invention also encompasses a kit using the polymeric material.Type: ApplicationFiled: June 28, 2007Publication date: August 20, 2009Applicant: Scil Technology GmbHInventors: Wolfgang Friess, Klaus Hellerbrand, Samuel Herberg, Cornelius Pompe, Andreas Schuetz, Michael Siedler
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Publication number: 20090148487Abstract: The present invention is directed to a moldable biomaterial comprising a particulate solid porous material and a biodegradable paste material. The paste material and the particulate solid porous material form a matrix usable for the replacement or augmentation of bone. In various embodiments the matrix has a high structural integrity, which does not immediately or shortly after implantation collapse into an amorphous non-porous mass, maintains its porosity after implantation, shows biphasic degradation after implantation and/or has a good resistance against being washed out when it is applied to a wet opened implant site. Active agents can be incorporated in the moldable biomaterial of the present invention, such as bone growth factors. Kits, implants, method of manufacturing as well as medicinal uses are also provided.Type: ApplicationFiled: December 14, 2006Publication date: June 11, 2009Applicant: SCIL TECHNOLOGY GMBHInventors: Michael Siedler, Klaus Hellerbrand, Andreas Schuetz, Sabrina Tauer
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Publication number: 20090048145Abstract: An in-situ-hardening paste, containing an organic or inorganic filling material, a biodegradable polymer and a water soluble polymeric plasticizer was developed as a delivery system for an active agent with scaffold properties in the field of tissue regeneration. The hardened paste is sufficient mechanical stable to can be used as bone and cartilage replacement matrix. All components are full biocompatible, preferably bioresorbable and certified for parenteral application. The sustained release of peptides and proteins can be modulated by the composition and process design. The invention encompasses a pharmaceutical composition comprising the paste of the invention and relates to the use of said paste for the preparation of a pharmaceutical composition to be used for bone augmentation, for treating bone defects, for treating degenerative and traumatic disc disease, for treating bone dehiscence or to be used for sinus floor elevation.Type: ApplicationFiled: June 9, 2005Publication date: February 19, 2009Applicant: Scil Technology GmbHInventors: Klaus Hellerbrand, Michael Siedler, Andreas Schutz, Cornelius Pompe, Wolfgang Friess
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Publication number: 20070202144Abstract: The present invention relates to a method of coating of a device, preferably implants, with a substance comprising the steps of (a) contacting said device into a solution of said substrate or substance, and (b) drying said device while being submerged in said solution. The present invention also relates to a packaging container for a device, preferably an implant. Said packaging container being adapted such that said device is coatable within said packaging container. Moreover, the present invention relates to a method of coating the inner surfaces of a packaging container for a device, preferably implants, to be coated by a substance, comprising the steps of (a) siliconizing said inner surfaces of said container using a silicone emulsion, and (b) heat-curing to form a baked-in silicone layer on said inner surfaces of said container.Type: ApplicationFiled: March 9, 2005Publication date: August 30, 2007Applicant: Scil Technology GmbHInventors: Klaus Hellerbrand, Michael Siedler, Andreas Schutz, Bernd Schimkat, Karin Wiedenmann-Schlembach
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Patent number: 6890897Abstract: A melanoma inhibiting activity factor (MIA), preferably in combination with an osteoinductive protein, is a useful pharmaceutical agent for promoting bone healing and/or cartilage repair.Type: GrantFiled: January 27, 2000Date of Patent: May 10, 2005Assignee: Scil Technology GmbHInventors: Carola Dony, Gabriele Proetzel, Ulrike Leser-Reiff