Patents Assigned to Scinopharm (Changshu) Pharmaceuticals, Ltd.
  • Process of preparing a quinazoline derivative
    Patent number: 9617227
    Abstract: A concise, efficient and cost- and time-saving process for the preparation of a quinazoline derivative of formula A given below: which is an intermediate for making gefitinib or gefitinib itself, comprising reacting a compound of Formula B: with 3-chloro-4-fluoroaniline (VI) in the presence of a N,N-dialkyl formamide acetal, a Bronsted acid catalyst, and a solvent in a one-pot reaction.
    Type: Grant
    Filed: June 10, 2014
    Date of Patent: April 11, 2017
    Assignee: SCINOPHARM (CHANGSHU) PHARMACEUTICALS, LTD.
    Inventors: Xiaoheng Zhang, Xizhou Lv
  • Process for preparation of roflumilast
    Patent number: 9233925
    Abstract: The present invention provides novel processes for the preparation of N-substituted benzamides having the formula VIc: In some embodiments, the invention provides a process for preparation of roflumilast and other pharmaceutically active species. Novel compounds, including intermediates for the synthesis of roflumilast, are also provided.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: January 12, 2016
    Assignee: ScinoPharm (Changshu) Pharmaceuticals, Ltd.
    Inventors: Yi-Jing Chen, Stanislaw Pikul, Shen-Chun Kuo, Guo-dong Chu
  • Process for preparation of roflumilast
    Patent number: 9085533
    Abstract: The present invention provides novel processes for the preparation of N-substituted benzamides having the formula (VIc). In some embodiments, the invention provides a process for preparation of roflumilast and other pharmaceutically active species. Novel compounds, including intermediates for the synthesis of roflumilast, are also provided.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: July 21, 2015
    Assignee: ScinoPharm (Changshu) Pharmaceuticals, Ltd.
    Inventors: Yi-Jing Chen, Stanislaw Pikul, Shen-Chun Kuo, Guo-dong Chu
  • PROCESS FOR PREPARATION OF ROFLUMILAST
    Publication number: 20150025246
    Abstract: The present invention provides novel processes for the preparation of N-substituted benzamides having the formula (VIc). In some embodiments, the invention provides a process for preparation of roflumilast and other pharmaceutically active species. Novel compounds, including intermediates for the synthesis of roflumilast, are also provided.
    Type: Application
    Filed: March 7, 2013
    Publication date: January 22, 2015
    Applicant: Scinopharm (Changshu) Pharmaceuticals, Ltd.
    Inventors: Yi-Jing Chen, Stanislaw Pikul, Shen-Chun Kuo, Guo-dong Chu
  • PROCESS FOR THE PREPARATION OF TAFLUPROST AND INTERMEDIATES THEREOF
    Publication number: 20140046086
    Abstract: The present invention provides efficient, economical and environmental friendly methods for synthesis of prostaglandin analogs including tafluprost and intermediates thereof. The invention involves a selective oxidation using in situ boronate ester protection and a unique crystallization method to remove the undesired isomers of fluorinated intermediates.
    Type: Application
    Filed: August 8, 2013
    Publication date: February 13, 2014
    Applicant: Scinopharm (Changshu) Pharmaceuticals, Ltd.
    Inventor: Wen-Hsien Wen