Patents Assigned to Scinopharm Singapore Pte Ltd.
  • Process for the preparation of disaccharides applied to heparin pentasaccharides
    Patent number: 8889853
    Abstract: The invention provides an intermediate and the process for making the same. This intermediate is useful in the process for making polysaccharides, and more particularly fondaparinux.
    Type: Grant
    Filed: October 5, 2011
    Date of Patent: November 18, 2014
    Assignee: Scinopharm Singapore Pte Ltd.
    Inventors: Tsung Yu Hsiao, Chen Wei Lin
  • Process for reduction of alpha-acyloxy sulfide derivatives
    Patent number: 8722921
    Abstract: The present invention provides an efficient and scalable process to prepare the compound of formula 4 by reduction of the corresponding ?-acyloxy sulfides.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: May 13, 2014
    Assignee: ScinoPharm Singapore PTE, Ltd.
    Inventors: JyhHsiung Liao, LungHuang Kuo
  • PROCESS FOR REDUCTION OF ALPHA-ACYLOXY SULFIDE DERIVATIVES
    Publication number: 20120220784
    Abstract: The present invention provides an efficient and scalable process to prepare the compound of formula 4 by reduction of the corresponding ?-acyloxy sulfides.
    Type: Application
    Filed: February 24, 2012
    Publication date: August 30, 2012
    Applicant: ScinoPharm Singapore PTE, Ltd.
    Inventors: JyhHsiung Liao, LungHuang Kuo
  • REAL-TIME MONITOR SOLID PHASE PEPTIDE SYNTHESIS BY MASS SPECTROMETRY
    Publication number: 20120107941
    Abstract: Provided are systems, apparatus, materials and methods for directly monitoring products and intermediates of solid phase chemical synthesis such as solid phase peptide synthesis.
    Type: Application
    Filed: October 28, 2011
    Publication date: May 3, 2012
    Applicants: SCINOPHARM TAIWAN, LTD., SCINOPHARM SINGAPORE PTE, LTD., NATIONAL SUN YAT-SEN UNIVERSITY
    Inventors: Li-Chiao Chang, Jentaie Shiea, Yi-Tzu Cho
  • Process for the Preparation of disaccharides Applied to Heparin Pentasaccharides
    Publication number: 20120083594
    Abstract: The invention provides an intermediate and the process for making the same. This intermediate is useful in the process for making polysaccharides, and more particularly fondaparinux.
    Type: Application
    Filed: October 5, 2011
    Publication date: April 5, 2012
    Applicant: ScinoPharm Singapore PTE Ltd.
    Inventors: Tsung Yu Hsiao, Chen Wei Lin
  • Crystalline forms of docetaxel and process for preparation thereof
    Patent number: 7662980
    Abstract: Anbydrous crystalline form of docetaxel and process of making anhydrous docetaxel and docetaxel trihydrate are provided.
    Type: Grant
    Filed: October 19, 2007
    Date of Patent: February 16, 2010
    Assignee: Scinopharm Singapore PTE Ltd.
    Inventors: Yuan-Xiu Liao, Meng-Fen Ho, Shu-Ping Chen, Chia-Ning Lin, Yu-Li Lin, Tsung-Yu Hsiao
  • Crystalline forms of docetaxel and process for preparation thereof
    Publication number: 20080108693
    Abstract: New anhydrous crystalline form of docetaxel and process of making anhydrous docetaxel and docetaxel trihydrate are provided.
    Type: Application
    Filed: October 19, 2007
    Publication date: May 8, 2008
    Applicant: Scinopharm Singapore PTE Ltd.
    Inventors: Yuan-Xiu Liao, Meng-Fen Ho, Shu-Ping Chen, Chia-Ning Lin, Yu-Li Lin, Tsung-Yu Hsiao
  • Process for preparing pergolide
    Patent number: 6388079
    Abstract: This invention relates to a process for preparing pergolide, which comprises the steps of reacting 9,10-dihydrolysergol with an acid anhydride at an elevated temperature in the presence of a catalyst to form a triacylated product intermediate; reducing the triacylated product intermediate with a reducing agent in a solvent to form a primary amino alcohol intermediate; and reacting the amino alcohol intermediate with dimethyl disulfide and trialkyl phosphine, aryl phosphine or the polymeric derivatives of phosphine analogs thereof in a polar solvent to obtain pergolide; or the steps of reacting 9,10-dihydrolysergol with dimethyl disulfide and trialkyl phosphine, aryl phosphine or the polymeric derivatives of phosphine analogs thereof in a polar solvent to form a methylsulfide intermediate; reacting the methylsulfide intermediate with an acid anhydride at an elevated temperature in the presence of a catalyst to form a diacylated amide intermediate; and reducing the diacylated amide intermediate with a reducing
    Type: Grant
    Filed: August 29, 2000
    Date of Patent: May 14, 2002
    Assignee: Scinopharm Singapore Pte Ltd.
    Inventors: Edwin S. C. Wu, Mark Wu